A click chemistry approach to identify protein targets of cancer chemopreventive phenethyl isothiocyanate

Ying Fu; Lixin Mi; Miloslav Sanda; Shana Silverstein; Monika Aggarwal; Deyun Wang; Pankaj Gupta; Radoslav Goldman; Daniel H. Appella; Fung-Lung Chung

doi:10.1039/C3RA46849F

A click chemistry approach to identify protein targets of cancer chemopreventive phenethyl isothiocyanate†

Ying Fu,‡^a Lixin Mi,‡^a Miloslav Sanda,^a Shana Silverstein,^a Monika Aggarwal,^a Deyun Wang,^b Pankaj Gupta,^b Radoslav Goldman,^a Daniel H. Appella*^b and Fung-Lung Chung*^a

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* Corresponding authors

^a Lombardi Cancer Research Centre, Georgetown University, Washington, DC, USA
E-mail: flc6@georgetown.edu
Fax: +1 202-587-1068
Tel: +1 202-687-6305

^b NIDDK, National Institutes of Health, Bethesda, MD 20814, USA
E-mail: appellad@niddk.nih.gov
Fax: +1 301-480-4977
Tel: +1 301-451-1052

Abstract

Here we report the identification of protein targets of chemopreventive phenethyl isothiocyanate (PEITC) via “click” chemistry in the A549 human lung cancer cell line, using a novel alkyne-tagged PEITC which was also found to show potent in vitro anticancer activity.

RSC Advances

A click chemistry approach to identify protein targets of cancer chemopreventive phenethyl isothiocyanate†

Abstract

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A click chemistry approach to identify protein targets of cancer chemopreventive phenethyl isothiocyanate

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