Issue 5, 2013
From the journal:

Biomaterials Science

Microwave-assisted rapid synthesis of poly(glycerol-sebacate) elastomers

H. M. Aydin,*a   K. Salimi,b   Z. M. O. Rzayevc  and  E. Pişkinab  

* Corresponding authors

a Institute of Science, Bioengineering Division, Hacettepe University, Beytepe, Ankara, Turkey
E-mail: hmaydin@hacettepe.edu.tr
Fax: +90 312 299 21 24
Tel: +90 533 551 58 30

b Chemical Engineering Department and Bioengineering Division, Centre for Bioengineering and Biyomedtek, Hacettepe University, Beytepe, Ankara, Turkey

c Institute of Science, Nanotechnology and Nanomedicine Division, Hacettepe University, Beytepe, Ankara, Turkey

Abstract

Poly(glycerol-sebacate) (PGS) was introduced a decade ago as a potential material for soft tissue repair. All of the proposed copolymerization reactions in the literature include a two-stage (prepolymerization and curing) synthesis where the reaction times can take as long as several days. This study, on the other hand, proposes a new route that eliminates these disadvantages and enables a rapid synthesis of PGS elastomers via microwave-assisted prepolymerization in minutes instead of days. No purge gas, catalyst or vacuum is needed in the first prepolymerization step. The curing stage was carried out at 150 °C for 4, 8, 16, and 24 hours. The glass transition temperature (Tg) and melting temperatures for the glycerol and sebacic acid fragments (Tm1 and Tm2) of these PGS elastomers were found as −35.61 °C, −15.82 °C, and 61.70 °C, respectively. The Young's modulus and tensile strength values were found as 0.50 ± 0.02 MPa and 0.27 ± 0.06 MPa, respectively.

Graphical abstract: Microwave-assisted rapid synthesis of poly(glycerol-sebacate) elastomers

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Article information

DOI
https://doi.org/10.1039/C3BM00157A
Article type
Paper
Submitted
04 Sep 2012
Accepted
23 Jan 2013
First published
25 Feb 2013

Biomater. Sci., 2013,1, 503-509

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Microwave-assisted rapid synthesis of poly(glycerol-sebacate) elastomers

H. M. Aydin, K. Salimi, Z. M. O. Rzayev and E. Pişkin, Biomater. Sci., 2013, 1, 503 DOI: 10.1039/C3BM00157A

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