Issue 11, 1994
From the journal:

Journal of the Chemical Society, Chemical Communications

Irreversible inhibition of mammalian and insect peptidylglycine α-hydroxylating monooxygenases (PHMS), peptide amidating enzymes, by N-formyl amides

Michael Klinge,   Hengmiao Cheng,   T. Mark Zabriskie  and  John C. Vederas  

Abstract

A series of N-formyl amides were synthesized by condensation of N,N-bis(trimethylsilyl)formamide with acid chlorides (59–90% yields), or by reaction of hydroxyglycyl peptides with 90% hydrogen peroxide (45% yield); a number of N-formyl amides which bear a phenyl substituent are mechanis-based irreversible inactivators of peptidylglycine α-hydroxylating monooxygenases purified from pig pituitary and from honeybee heads.

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Article information

DOI
https://doi.org/10.1039/C39940001379
Article type
Paper

J. Chem. Soc., Chem. Commun., 1994, 1379-1380

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Irreversible inhibition of mammalian and insect peptidylglycine α-hydroxylating monooxygenases (PHMS), peptide amidating enzymes, by N-formyl amides

M. Klinge, H. Cheng, T. M. Zabriskie and J. C. Vederas, J. Chem. Soc., Chem. Commun., 1994, 1379 DOI: 10.1039/C39940001379

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