Issue 8, 1994
From the journal:

Journal of the Chemical Society, Chemical Communications

1,4-Diazabicyclo[2.2.2]octane (DABCO)-catalysed hydrolysis and alcoholysis reactions of 2-amino-9-benzyl-6-chloro-9H-purine

James A. Linn,   Ed W. McLean  and  James L. Kelley  

Abstract

2-Amino-9-benzyl-6-chloro-9H-purine 1 is hydrolysed in refluxing water in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) to give 2-amino-9-benzyl-1,6-dihydro-6-oxo-9H-purine 3; however, 1 reacts with hydroxide ion at ambient temp., or analcohol and potassium carbonate at elevated temperatures, in the presence of DABCO togive 3 or 6-alkoxy-2-amino-9-benzyl-9H-purines 4–8, respectively.

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Article information

DOI
https://doi.org/10.1039/C39940000913
Article type
Paper

J. Chem. Soc., Chem. Commun., 1994, 913-914

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1,4-Diazabicyclo[2.2.2]octane (DABCO)-catalysed hydrolysis and alcoholysis reactions of 2-amino-9-benzyl-6-chloro-9H-purine

J. A. Linn, E. W. McLean and J. L. Kelley, J. Chem. Soc., Chem. Commun., 1994, 913 DOI: 10.1039/C39940000913

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