Cobalt-catalysed three-component coupling involving ketones or ketoesters, aldehydes and acetonitrile: a novel one-pot synthesis of β-acetamido ketones
Abstract
Cobalt(II) chloride catalyses one-pot coupling of ketones or ketoesters, aldehydes and acetonitrile in the presence of acetyl chloride to give β-acetamido ketones 3 in good yields.