Issue 31, 2012
From the journal:

Dalton Transactions

One pot synthesis of structurally different mono and dimeric Ni(ii) thiosemicarbazone complexes and N-arylation on a coordinated ligand: a comparative biological study†

R. Prabhakaran,*a   P. Kalaivani,a   P. Poornima,b   F. Dallemer,c   G. Paramaguru,d   V. Vijaya Padma,b   R. Renganathan,d   R. Huange  and  K. Natarajan*a  

* Corresponding authors

a Department of Chemistry, Bharathiar University, Coimbatore 641 046, India
E-mail: rpnchemist@gmail.com, k_natraj6@yahoo.com
Fax: +91-422-2422387
Tel: +91-422-2428319

b Department of Biotechnology, Bharathiar University, Coimbatore 641 046, India

c Laboratoire Chimie Provence-CNRS UMR6264, Université of Aix-Marseille I, II and III – CNRS, Campus Scientifique de Saint-Jérôme, Avenue Escadrille Normandie-Niemen, F-13397 Marseille Cedex 20, France

d Department of Chemistry, Bharathidasan University, Trichirappalli 620 015, India

e Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA

Abstract

One pot synthesis of three structurally different Ni(II) thiosemicarbazone complexes 1, 2 and 3 were obtained from the reaction between [NiCl2(PPh3)2], 1,2-bis(diphenylphosphino)ethane, and [H2-(Sal-tsc)]. The obtained products were characterized by various spectral and analytical techniques. From the X-ray crystallographic analysis, an unexpected N-arylation on the coordinated salicylaldehydethiosemicarbazone was found in complex 2. The comparative biological evolutions such as DNA/protein binding, antioxidant, cytotoxicity (MTT, LDH, and NO) and cellular uptake studies have been examined for [Ni(Sal-tsc)(PPh3)] (1) and [(Ni(Sal-tsc))2(μ-dppe)] (3). When comparing the cytotoxicity of the complexes, 1 exhibited higher activity than 2 and 3 and by comparing with standard cis-platin, both of them were found to exhibit better activity under identical conditions.

Graphical abstract: One pot synthesis of structurally different mono and dimeric Ni(ii) thiosemicarbazone complexes and N-arylation on a coordinated ligand: a comparative biological study

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Article information

DOI
https://doi.org/10.1039/C2DT12231F
Article type
Paper
Submitted
21 Nov 2011
Accepted
17 May 2012
First published
25 Jun 2012

Dalton Trans., 2012,41, 9323-9336

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One pot synthesis of structurally different mono and dimeric Ni(II) thiosemicarbazone complexes and N-arylation on a coordinated ligand: a comparative biological study

R. Prabhakaran, P. Kalaivani, P. Poornima, F. Dallemer, G. Paramaguru, V. Vijaya Padma, R. Renganathan, R. Huang and K. Natarajan, Dalton Trans., 2012, 41, 9323 DOI: 10.1039/C2DT12231F

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