Issue 3, 2010
From the journal:

Green Chemistry

Palladium-catalysed Grignard cross-coupling using highly concentrated Grignards in methyl-tetrahydrofuran†

Edward J. Miltona  and  Matthew L. Clarke*a  

* Corresponding authors

a School of Chemistry, University of St Andrews, EaStCHEM, St Andrews, Fife, UK
E-mail: mc28@st-andrews.ac.uk
Fax: (44) 1334 463808
Tel: (44) 1334 463850

Abstract

The cross-coupling of Grignard reagents at 5 molar concentration in methyl-tetrahydrofuran with no added reaction solvents can be achieved with the appropriate matching of catalyst to substrate, significantly reducing solvent use when compared to a typical protocol in tetrahydrofuran. Me-THF was also used in an improved microwave accelerated synthesis of the [Pd(L)Cl2] pre-catalysts from sodium tetrachloropalladate in very high yield.

Graphical abstract: Palladium-catalysed Grignard cross-coupling using highly concentrated Grignards in methyl-tetrahydrofuran

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Article information

DOI
https://doi.org/10.1039/B921026A
Article type
Communication
Submitted
13 Oct 2009
Accepted
25 Nov 2009
First published
12 Jan 2010

Green Chem., 2010,12, 381-383

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Palladium-catalysed Grignard cross-coupling using highly concentrated Grignards in methyl-tetrahydrofuran

E. J. Milton and M. L. Clarke, Green Chem., 2010, 12, 381 DOI: 10.1039/B921026A

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