Issue 20, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Molecular recognition of xanthinealkaloids: First synthetic receptors for theobromine and a series of new receptors for caffeine

Shyamaprosad Goswami,*a   Ajit Kumar Mahapatraa  and  Reshmi Mukherjeea  

* Corresponding authors

a Department of Chemistry, Bengal Engineering College (Deemed University), Howrah-711103, India

Abstract

Synthetic receptors (H3, H4, H5 and H6) are designed and synthesised for the first time for theobromine, a xanthine alkaloid used as a diuretic. The synthesis of the receptor H6 is achieved by Co(PPh3)3Cl-mediated homocoupling of 3-(ethoxycarbonyl)benzyl bromide 12 under mild conditions. New caffeine receptors (H7, H8 and H9) are designed and synthesised. The binding results of theobromine and caffeine (both by NMR and UV studies) are reported.

Graphical abstract: Molecular recognition of xanthine alkaloids: First synthetic receptors for theobromine and a series of new receptors for caffeine

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Article information

DOI
https://doi.org/10.1039/B009319J
Article type
Paper
Submitted
20 Nov 2000
Accepted
10 Aug 2001
First published
04 Oct 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 2717-2726

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Molecular recognition of xanthine alkaloids: First synthetic receptors for theobromine and a series of new receptors for caffeine

S. Goswami, A. K. Mahapatra and R. Mukherjee, J. Chem. Soc., Perkin Trans. 1, 2001, 2717 DOI: 10.1039/B009319J

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