Issue 14, 1997
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Synthesis of oligodeoxynucleotides containing 5-aminouracil and its N-acetyl derivative

Elisenda Ferrer,   Gitte Neubauer,   Matthias Mann  and  Ramon Eritja  

Abstract

The preparation of oligonucleotides containing 5-amino-2′-deoxyuridine is described. Three different protective groups for the amino function of 5-aminouracil including trifluoroacetyl, dimethylformamidine and 2-(4-nitrophenyl)ethoxycarbonyl are analysed in order to reduce the acetylation of this base observed during the assembly of oligonucleotides containing this base analogue. The side-reaction is avoided by using the base-labile 2-(4-nitrophenyl)ethoxy as protecting group and 2-(4-nitrophenyl)ethyl chloroformate during the capping step.

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Article information

DOI
https://doi.org/10.1039/A701371J
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1997, 2051-2058

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Synthesis of oligodeoxynucleotides containing 5-aminouracil and its N-acetyl derivative

E. Ferrer, G. Neubauer, M. Mann and R. Eritja, J. Chem. Soc., Perkin Trans. 1, 1997, 2051 DOI: 10.1039/A701371J

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