Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Inhibition of 5-Hydroxytryptamine Liberation from Blood Platelets by Reserpine

Abstract

RESERPINE causes a release of monoamines from various tissues including isolated blood platelets1,2. This effect is generally attributed to an interference of the drug with the storage mechanisms for the amines. Furthermore, some authors report a protective action of reserpine against the spontaneous liberation of norepinephrine from, adrenal medullary and splenic nerve granules3–5. The mechanism is not fully understood. It might be partly connected with the lack of glucose in the incubation medium, because this source of energy seems to be necessary for retaining the 5-hydroxytryptamine (5HT) within the platelets6, We have investigated the effect of reserpine on the metabolism of 5HT of isolated platelets in the absence and presence of glucose.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Shore, P. A., Pharmacol. Rev., 14, 531 (1962).

    CAS  PubMed  Google Scholar 

  2. Carlsson, A., Shore, P. A., and Brodie, B. B., J. Pharmacol. Exp. Ther., 120, 334 (1957).

    CAS  PubMed  Google Scholar 

  3. Euler, U. S. von, and Lishajko, F., Acta Physiol. Scand., 52, 137 (1961).

    Article  CAS  Google Scholar 

  4. Weil-Malherbe, H., and Posner, H. S., J. Pharmacol. Exp. Ther., 140, 93 (1963).

    CAS  PubMed  Google Scholar 

  5. Weil-Malherbe, H., and Posner, H. S., Biochem. Pharmacol., 13, 685 (1964).

    Article  CAS  Google Scholar 

  6. McLean, J., Nicholson, A., and Hertler, D., Life Sci., 2, 683 (1963).

    Article  CAS  Google Scholar 

  7. Bartholini, G., and Pletscher, A., Experientia, 20, 376 (1964).

    Article  CAS  Google Scholar 

  8. Bogdanski, D. F., Pletscher, A., Brodie, B. B., and Udenfriend, S., J. Pharmacol. Exp. Ther., 117, 82 (1956).

    CAS  PubMed  Google Scholar 

  9. Bartholini, G., Pletscher, A., and Bruderer, H., Nature, 203, 1281 (1964).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

BARTHOLINI, G., DA PRADA, M. & PLETSCHER, A. Inhibition of 5-Hydroxytryptamine Liberation from Blood Platelets by Reserpine. Nature 205, 400–401 (1965). https://doi.org/10.1038/205400a0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/205400a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing