Abstract
THE preparation of various glutarimides in these laboratories for testing as possible analgesics led to the discovery1 in the Department of Pharmacology and Physiology, University of Melbourne, of the anti-barbiturate activity of ββ methyl ethyl glutarimide (‘Bemegride’, ‘Megimide’), from which a new method of treatment for barbiturate intoxication has been developed2. This prompted the investigation of related β-substituted glutarimides and derivatives of ‘Bemegride’ for similar activity. A series of compounds was therefore synthesized for examination, and the results of preliminary pharmacological trials are reported here.
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References
Shaw, F. H., Simon, S. R., Cass, N., Shulman, A., Anstee, J. R., and Nelson, E. R., Nature, 174, 402 (1954).
Shulman, A., Shaw, F. H., Cass, N., and Whyte, H. M., Brit. Med. J., i, 1238 (1955).
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SOMERS, T. New Analeptics and Hypnotics related to the Barbiturate Antagonist, ‘Bemegride’. Nature 178, 996–997 (1956). https://doi.org/10.1038/178996a0
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DOI: https://doi.org/10.1038/178996a0
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