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1-(Cyanoacetyl)-3,5-dimethylpyrazole as an effective alternative to cyanoacetic ester in the synthesis of 2,6-dioxopiperidine-3,5-dicarbonitrile derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

1-(Cyanoacetyl)-3,5-dimethylpyrazole reacted with 2-cyanoacrylamides in the presence of triethylamine with the formation of triethylammonium salts of 4-monosubstituted-2,6-dioxopiperidine-3,5-di-carbonitriles (Guareschi imides) or the products of their oxidation, the 4-aryl-3,5-dicyano-6-oxo-1,6-di-hydropyridin-2-olates.

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Authors and Affiliations

  1. Chemical Diversity Research Institute, 2a Rabochaya St., Khimki, 114401, Moscow Region, Russia

    E. A. Chigorina

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  1. E. A. Chigorina
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Correspondence to E. A. Chigorina.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 615–627, April, 2013.

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Chigorina, E.A. 1-(Cyanoacetyl)-3,5-dimethylpyrazole as an effective alternative to cyanoacetic ester in the synthesis of 2,6-dioxopiperidine-3,5-dicarbonitrile derivatives. Chem Heterocycl Comp 49, 574–585 (2013). https://doi.org/10.1007/s10593-013-1284-3

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  • DOI: https://doi.org/10.1007/s10593-013-1284-3

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