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The Twin-Family Method in Psychiatric Genetics Illustrated from the Investigations of Franz J. Kallmann

Published online by Cambridge University Press:  01 August 2014

L. A. Hurst
L. A. Hurst*
Affiliation:
Dept. of Psychiatry and Mental Hygiene, University of the Witwatersrand, Johannesburg
*
Dept. of Psychiatry and Mental Hygiene, University of the Witwatersrand, Johannesburg, South Africa

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The present paper is aimed to celebrate Franz J. Kallmann's memory, by illustrating the twin-family method, which he developed. His phenomenal powers of organization are testified to by his extensive samples. Their representative nature has the built-in check of the ratio of MZ: DZ twins. He brought a refinement of his own to the existing methods of calculating expectancy from nett figures, that permits comparison of studies of varying age distributions relative to manifestation period. His investigative design allows not only for the standard global concordance comparisons between DZ and MZ twins as well as for those reared together and apart, but exploits the implications of the hitherto neglected comparison of the categories of sibs and DZ twins also. Further, his combined twin-family method comprehends in its extended range the powerful analytical tool of comparative figures for the series step-sibs, half-sibs, sibs, DZ twins and MZ twins (Kallmann and Sander, 1947; Kallmann, 1953). Kallmann (1954a, 1954b) has moreover given minute attention to controversies concerning legitimate inferences from twin studies, and has drawn attention to a point made by Darlington (1953), which is often overlooked by the best of geneticists. Discordance between MZ twins is not a measure merely of postnatal or even of prenatal environmental effects: it may also have a genetic component through the action of genes sensitive to cytoplasmic asymmetry.

Type
Session 9 - Methodology of Twin Studies
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 19 , Issue 1-2 , April 1970 , pp. 135 - 139
Copyright
Copyright © The International Society for Twin Studies 1970

References

Darlington, C. D. (1953). The notions of heredity and environment. Proc. nth Int. Congr. Genet., Bellagio.Google Scholar
Erlenmeyer-Kimling, L., Rainer, J. D., Kallmann, F. J. (1966). Current Reproductive Trends in Schizophrenia. In: Psychopathology of Schizophrenia. Grune and Stratton, New York.Google Scholar
Falek, A., Kallmann, F. J., Lorge, I., Jarvik, L. F. (1960). Longevity and intellectual variation in a senescent twin population. J. Geront., 15: 305–309.Google Scholar
Jarvik, L. F., Falek, A., Kallmann, F. J., Lorge, I. (1960). Survival trends in a senescent population. Amer. J. Hum. Genet., 12: 170–179.Google Scholar
Jarvik, L. F., Kallmann, F. J., Falek, A. (1962 a). Psychiatric genetics and aging. Gerontologist, 1: 164–166.Google Scholar
Jarvik, L. F., Kallmann, F. J., Falek, A. (1962 b). Intellectual changes in aged twins. J. Geront., 17: 289–294.Google Scholar
Kallmann, F. J. (1938 a). Eugenic birth control in schizophrenic families. J. Contracept., 11: 195–199.Google Scholar
Kallmann, F. J. (1938 a). The Genetics of Schizophrenia. A Study of Heredity and Reproduction in Families of 1087 Schizophrenics. J. J. Augustin Publisher, New York.Google Scholar
Kallmann, F. J. (1946). The genetic theory of schizophrenia. An analysis of 691 schizophrenic twin index families. Amer. J. Psychiat., 103: 309–322.Google Scholar
Kallmann, F. J. (1948 a). Applicability of modern genetic concepts in the management of schizophrenia. J. Hered., 39: 339–344.Google Scholar
Kallmann, F. J. (1948 b). Heredity and Constitution in Relation to the Treatment of Mental Disorders. In Hoch, P.: Failures in Psychiatric Treatment. Grune and Stratton, New York.Google Scholar
Kallmann, F. J. (1949). Zur Häufigkeit und psychopathologischen Motivierung des Selbstmordes bei Zwillingen und alleinigen Kindern. Mschr. Psychiat. Neurol., 117: 280–288.Google Scholar
Kallmann, F. J. (1950). The Genetics of Psychoses. An Analysis of 1232 Twin Index Families. Hermann & Cie, Paris.Google Scholar
Kallmann, F. J. (1951). Twin studies in relation to adjustive problems in man. Trans. N. Y. Acad. Sci., 13: 270–275.Google Scholar
Kallmann, F. J. (1952 a). The genetic aspects of mental disorders in the aging. Comparative twin data on the involutional and senile periods of life. J. Hered., 43: 89–96.Google Scholar
Kallmann, F. J. (1952 b). Comparative twin study on genetic aspects of male homosexuality. J. Nerv. Ment. Dis., 115: 283–298.Google Scholar
Kallmann, F. J. (1952 c). Twin and sibship study of overt male homosexuality. J. Hum. Genet., 4: 136–146.Google Scholar
Kallmann, F. J. (1952 d). Psychiatric guidance in problems of marriage and parenthood. Eugen. News, 36: 55–59.Google Scholar
Kallmann, F. J. (1952 e). Human genetics as a science, as a profession, and as a social-minded trend of orientation. Amer. J. Hum. Genet., 4: 237–245.Google Scholar
Kallmann, F. J. (1953). Heredity in Health and Mental Disorder. W. W. Norton and Co., New York.Google Scholar
Kallmann, F. J. (1954 a). Genetic Principles in Manic Depressive Psychosis. In Hoch, P. and Zubin, J.: Depression. Grune and Stratton, New York.Google Scholar
Kallmann, F. J. (1954 b). Twin data in the analysis of mechanisms of inheritance. Amer. J. Hum. Genet., 6: 157–162.Google Scholar
Kallmann, F. J. (1956 a). Psychiatric aspects of genetic counseling. Amer. J. Hum. Genet., 8: 97–101.Google Scholar
Kallmann, F. J. (1956 b). Objectives of the mental health project for the deaf. Proc. Convention of American Instructors of the Deaf, 1955.Google Scholar
Kallmann, F. J. (1961 a). Genetic Factors in Aging: Comparative and Longitudinal Observations on a Senescent Twin Population. In Hoch, P. and Zubin, J.: Psychopathology of Aging. Grune and Stratton, New York.Google Scholar
Kallmann, F. J. (1961 b). The hybrid specialty of psychiatric genetics. Acta Genet. Med. Gemellol., 11: 317–230.Google Scholar
Kallmann, F. J. (1961 c). New goals and perspectives in human genetics. Acta Genet. Med. Gemellol., 11: 377–388.Google Scholar
Kallmann, F. J. Barrera, S., Hoch, P. H., Kelley, M. (1941). The role of mental deficiency in the incidence of schizophrenia. Amer. J. Ment. Defic, 35: 514–539.Google Scholar
Kallmann, F. J. Reisner, D. (1943). Twin studies on the significance of genetic factors in tuberculosis. Amer. Rev. Tuberc, 47: 549–574.Google Scholar
Anastasio, M. (1946). Twin studies of the psychopathology of suicide. J. Hered., 37: 171–180.Google Scholar
Anastasio, M. Mickey, J. S. (1946). The concept of induced insanity in family units. J. Nerv. Ment. Dis., 104: 303–315.Google Scholar
Anastasio, M. Sander, G. (1947). The Genetics of Epilepsy. In Hoch, P. and Knight, : Epilepsy. Grune and Stratton, New York.Google Scholar
Anastasio, M. Sander, G. (1948). Twin studies on aging and longevity. J. Hered., 39: 349–357.Google Scholar
Anastasio, M. Sander, G. (1949). Twin studies on senescence. Amer. J. Psychiat., 106: 29–36.Google Scholar
Anastasio, M. Deporte, J., Deporte, E., Feingold, L. (1949). Suicide in twins and only children. Amer. J. Hum. Genet., 1: 113–126.Google Scholar
Anastasio, M. Feingold, L., Bondy, E. (1951). Comparative adaptational, social and psychiatric data on the life histories of senescent twin pairs. Amer. J. Hum. Genet., 3: 65–73.Google Scholar
Anastasio, M. Bondy, E. (1952). Applicability of the twin study method in the analysis of variations in mate selection and marital adjustment. Amer. J. Hum. Genet., 4: 209–222.Google Scholar
Anastasio, M. Roth, B. (1956). Genetic aspects of preadolescent schizophrenia. Amer. J. Psychiat., 112: 599–606.Google Scholar
Anastasio, M. Erlenmeyer-Kimling, L., Glanville, E. V., Rainer, J. D. (1962). Expanding Goals of Genetics in Psychiatry. Grune and Stratton, New York.Google Scholar
Anastasio, M. Rainer, J. D. (1963). Psychotherapeutically Oriented Counseling Techniques in the Setting of a Medical Genetics Department. Topical Problems in Psychotherapy. Vol. 4. Karger, Basel.Google Scholar
Anastasio, M. Rainer, J. D. (1964)). The genetic approach to schizophrenia: clinical, demographic and family guidance problems. Int. Psychiat. Clin., 1: 799–820.Google Scholar
Anastasio, M. Falek, A., Hurzeler, M., Erlenmeyer-Kimling, L. (1964). The Developmental Aspects of Children with Two Schizophrenic Parents. Psychiatric Research Report 19, American Psychiatric Association.Google Scholar
Rainer, J. D., Altshuler, D. Z., Kallmann, F. J. (1963 a). Psychotherapy for the Deaf. In: Advances in Psychosomatic Medicine. Vol. III. Karger, Basel.Google Scholar
Rainer, J. D., Altshuler, D. Z., Kallmann, F. J. (1963 b). Family and Mental Health Problems in a Deaf Population. Dept. of Medical Genetics, New York State Psychiatric Institute.Google Scholar
Sank, D., Kallmann, F. J. (1956). Genetic and eugenic aspects of early total deafness. Eugen. Quart., 3: 69–74.Google Scholar