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The role of intraindividual cognitive variability in posttraumatic stress syndromes and cognitive aging: a literature search and proposed research agenda

Published online by Cambridge University Press:  16 March 2020

Lauren A. Rutter Open the ORCID record for Lauren A. Rutter [Opens in a new window] ,
Ipsit V. Vahia ,
Eliza Passell ,
Brent P. Forester  and
Laura Germine
Lauren A. Rutter*
Affiliation:
Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, IN, USA
Ipsit V. Vahia
Affiliation:
Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA Division of Geriatric Psychiatry, McLean Hospital, Belmont, MA, USA
Eliza Passell
Affiliation:
Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA
Brent P. Forester
Affiliation:
Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA Division of Geriatric Psychiatry, McLean Hospital, Belmont, MA, USA
Laura Germine
Affiliation:
Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA
*
Correspondence should be addressed to: Lauren A. Rutter, Department of Psychological and Brain Sciences, Indiana University Bloomington, 1101 E. 10th St., Bloomington, IN 47405, USA. Email: larutter@iu.edu.
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Abstract

Objectives:

Cognitive impairments are directly related to severity of symptoms and are a primary cause for functional impairment. Intraindividual cognitive variability likely plays a role in both risk and resiliency from symptoms. In fact, such cognitive variability may be an earlier marker of cognitive decline and emergent psychiatric symptoms than traditional psychiatric or behavioral symptoms. Here, our objectives were to survey the literature linking intraindividual cognitive variability, trauma, and dementia and to suggest a potential research agenda.

Design:

A wide body of literature suggests that exposure to major stressors is associated with poorer cognitive performance, with intraindividual cognitive variability in particular linked to the development of posttraumatic stress disorder (PTSD) in the aftermath of severe trauma.

Measurements:

In this narrative review, we survey the empirical studies to date that evaluate the connection between intraindividual cognitive variability, PTSD, and pathological aging including dementia.

Results:

The literature suggests that reaction time (RT) variability within an individual may predict future cognitive impairment, including premature cognitive aging, and is significantly associated with PTSD symptoms.

Conclusions:

Based on our findings, we argue that intraindividual RT variability may serve as a common pathological indicator for trauma-related dementia risk and should be investigated in future studies.

Keywords

cognitive impairmentcognitive assessmentposttraumatic stress disorder (PTSD)agingrisk factors
Type
Review Article
Information
International Psychogeriatrics , Volume 33 , Special Issue 7: Issue Theme: Cognitive Aging: Subjective and Objective , July 2021 , pp. 677 - 687
Copyright
© International Psychogeriatric Association 2020

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