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Are depressive symptoms in mild cognitive impairment predictive of conversion to dementia?

Published online by Cambridge University Press:  18 January 2016

Ellen De Roeck ,
Ingrid Ponjaert-Kristoffersen ,
Marc Bosmans ,
Peter Paul De Deyn ,
Sebastiaan Engelborghs  and
Eva Dierckx
Ellen De Roeck
Affiliation:
Developmental and Lifespan Psychology, Vrije Universiteit Brussel, Brussels, Belgium Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
Ingrid Ponjaert-Kristoffersen
Affiliation:
Developmental and Lifespan Psychology, Vrije Universiteit Brussel, Brussels, Belgium
Marc Bosmans
Affiliation:
Developmental and Lifespan Psychology, Vrije Universiteit Brussel, Brussels, Belgium
Peter Paul De Deyn
Affiliation:
Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA), Middelheim and Hoge Beuken, Antwerp, Belgium Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium Department of Neurology and Alzheimer Research Center, University of Groningen, University Medical Center Groningen (UMCG), Groningen, the Netherlands
Sebastiaan Engelborghs
Affiliation:
Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA), Middelheim and Hoge Beuken, Antwerp, Belgium Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
Eva Dierckx*
Affiliation:
Developmental and Lifespan Psychology, Vrije Universiteit Brussel, Brussels, Belgium Alexian Brothers Hospital, Tienen, Belgium
*
Correspondence should be addressed to: Prof. Dr. Eva Dierckx, Faculty of Psychology and Educational Sciences, Pleinlaan 2, 1050 Brussels, Belgium. Phone: + 32 2 629 36 22; Fax: + 32-2-629 25 32. Email: eva.dierckx@vub.ac.be.
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Abstract

Background:

Depressive symptoms are common in amnestic mild cognitive impairment (aMCI). The association between depressive symptoms and conversion to dementia is not yet clear. This longitudinal study was conducted to ascertain whether depressive symptoms in aMCI patients are predictive of conversion to dementia.

Methods:

35 aMCI patients participated in this study. All participants underwent cognitive testing and were administered the geriatric depression scale (GDS) to determine the presence of depressive symptoms. A score equaling or higher than 11 on the GDS was taken as the cut-off point for presence of significant depressive symptoms. Conversion to dementia was assessed at follow-up visits after 1.5, 4, and 10 years.

Results:

31.4% of the patients reported depressive symptoms at baseline. None of the cognitive measures revealed a significant difference at baseline between patients with and without depressive symptoms. After 1.5, 4, and 10 years respectively 6, 14, and 23 patients had converted to dementia. Although the GDS scores at baseline did not predict conversion to dementia, the cognitive measures and more specifically a verbal cued recall task (the memory impairment scale-plus) was a good predictor for conversion.

Conclusions:

Based on this dataset, the presence of depressive symptoms in aMCI patients is not predictive of conversion to dementia.

Keywords

depressive symptomsdepressionmild cognitive impairmentdementiaconversionAlzheimer's disease
Type
Research Article
Information
International Psychogeriatrics , Volume 28 , Issue 6 , June 2016 , pp. 921 - 928
Copyright
Copyright © International Psychogeriatric Association 2016 

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