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Screening for Alzheimer's dementia at age 78 with short psychometric instruments

Published online by Cambridge University Press:  27 March 2009

S. Jungwirth ,
S. Zehetmayer ,
P. Bauer ,
S. Weissgram ,
K. H. Tragl  and
P. Fischer
S. Jungwirth*
Affiliation:
Ludwig Boltzmann Institute of Aging Research, Vienna, Austria
S. Zehetmayer
Affiliation:
Medical University of Vienna, Section for Medical Statistics, Vienna Austria
P. Bauer
Affiliation:
Medical University of Vienna, Section for Medical Statistics, Vienna Austria
S. Weissgram
Affiliation:
Ludwig Boltzmann Institute of Aging Research, Vienna, Austria
K. H. Tragl
Affiliation:
Ludwig Boltzmann Institute of Aging Research, Vienna, Austria
P. Fischer
Affiliation:
Ludwig Boltzmann Institute of Aging Research, Vienna, Austria Department of Psychiatry, Danube Hospital, Vienna, Austria
*
Correspondence should be addressed to: Susanne Jungwirth, Ludwig Boltzmann Institute of Aging Research, Langobardenstraße 122, 1220 Vienna, Austria. Phone: +43 1 28802 4209; Fax: +43 1 28802 4281. E-mail: Susanne.Jungwirth@wienkav.at.
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Abstract

Background: To date, no single instrument has proved to be adequate for screening for Alzheimer's dementia (AD). The aim of this study was to identify a combination of instruments which were highly sensitive for screening late onset AD.

Methods: Subjects were drawn from the Vienna TransDanube Aging (VITA) study. This is an interdisciplinary, longitudinal community-based cohort study of the 21st and 22nd district of Vienna (Austria). Data refer to the cohort of 478 individuals at age 78 who took part in the first follow-up investigation of the VITA study. The psychometric instruments which were investigated were: the Ten-Point Clock Test, the Human-Figure Drawing Test, a Delayed Selective Reminding Test, Naming, the Trail Making Test-B, and Verbal Fluency. Further instruments were the Pocket Smell Test, and Subjective Memory Complaints. Data were analyzed using logistic regression analyses and cross validation.

Results: A combination of the Delayed Selective Reminding Test and Verbal Fluency was best for screening AD (R2 = 0.38, main model). An area under the ROC curve of 0.829 was reached. This model discriminated between subjects with incident AD and subjects who did not have incident AD with a sensitivity of 91% and a specificity of 56%.

Conclusion: The combination of an episodic memory test and a test of verbal fluency was an effective way of screening for AD.

Keywords

VITA-studylongitudinalpopulation-baseddelayed selective remindingverbal fluency
Type
Research Article
Information
International Psychogeriatrics , Volume 21 , Issue 3 , June 2009 , pp. 548 - 559
Copyright
Copyright © International Psychogeriatric Association 2009

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