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Hemorrhagic Changes in Experimental Spinal Cord Injury Models

Published online by Cambridge University Press:  18 September 2015

Moe Khan ,
Robert Griebel ,
Bodan Rozdilsky  and
Michael Politis
Moe Khan*
Affiliation:
Departments of Neurosciences, Neuropathology and Anatomy. University of Saskatchewan, Saskatoon. Saskatchewan. Canada
Robert Griebel
Affiliation:
Departments of Neurosciences, Neuropathology and Anatomy. University of Saskatchewan, Saskatoon. Saskatchewan. Canada
Bodan Rozdilsky
Affiliation:
Departments of Neurosciences, Neuropathology and Anatomy. University of Saskatchewan, Saskatoon. Saskatchewan. Canada
Michael Politis
Affiliation:
Departments of Neurosciences, Neuropathology and Anatomy. University of Saskatchewan, Saskatoon. Saskatchewan. Canada
*
Dept. of Clinical Neurological Sciences. University Hospital, Saskatoon. Saskatchewan. Canada S7K. 0X0
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Abstract:

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Early hemorrhagic changes in the spinal cord were compared in three experimental spinal cord injury models in the rat in order to determine the nature and consistency of spinal cord hemorrhage following specific and quantitated forces of injury. The spinal cords were injured by weight-dropping, aneurysm clip and extradural balloon compression techniques. Hemorrhagic changes were assessed quantitatively by the image analyser at 1 and 3 hours after injury. Tissue damage was assessed by determining the percentage of total cross sectional area containing hemorrhage. The extent of hemorrhage at site of injury in the clip and balloon preparations was equal, but several times lower in the weight-drop induced injury. Within each experimental group no appreciable differences were observed at the site of injury between the 1 and 3 hours preparations. The variability of damage within experimental groups was most in the weight-dropping and balloon and least in the clip preparations. Differences were also indicated with respect to the distribution of hemorrhage in grey versus white matter. These findings may be of significance when functional recovery is considered in various experimental acute spinal cord injury models.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 12 , Issue 3 , August 1985 , pp. 259 - 262
Copyright
Copyright © Canadian Neurological Sciences Federation 1985

References

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