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‘Host’ antigens associated with schistosomes: observations on their attachment and their nature

Published online by Cambridge University Press:  06 April 2009

J. A. Clegg ,
S. R. Smithers  and
R. J. Terry
J. A. Clegg
Affiliation:
Division of Parasitology, National Institute for Medical Research, London, N. W.7 and Department of Biology, Brunel University, London, W.3
S. R. Smithers
Affiliation:
Division of Parasitology, National Institute for Medical Research, London, N. W.7 and Department of Biology, Brunel University, London, W.3
R. J. Terry
Affiliation:
Division of Parasitology, National Institute for Medical Research, London, N. W.7 and Department of Biology, Brunel University, London, W.3
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Extract

Further investigations have been carried out on the nature of ‘host’ antigens associated with the adult worms of Schistosoma mansoni. These investigations show:

1. The ‘host’ antigens are not removed from the surface of the worms by thorough washing and prolonged incubation in Hanks's balanced salts solution. The antigens must be firmly bound or even incorporated at the surface.

2. Monkeys cannot be immunized against ‘mouse worms’ with mouse IgG immunoglobulins. Accordingly it is unlikely that the ‘host’ antigens are mouse anti-worm antibodies.

3. The ‘host’ antigens are certainly associated with the membranes of mouse erythrocytes. They may also be associated with the ‘soluble protein’ fraction of the erythrocytes.

4. Immunization with sheep erythrocytes failed to protect monkeys against challenge with ‘mouse’ worms. Therefore it is unlikely that the ‘host’ antigens are Forssman antigen.

5. The mouse ‘host’ antigens associated with ‘mouse’ worms are not major histocompatibility antigens. Consequently it is likely that they are species-specific mouse antigens.

Type
Research Article
Information
Parasitology , Volume 61 , Issue 1 , August 1970 , pp. 87 - 94
Copyright
Copyright © Cambridge University Press 1970

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References

REFERENCES

Antunes, L. J. & Pellegrino, J. (1967). Heterophile antibodies in schistosomiasis mansoni. Journal of Parasitology 53, 303–5.CrossRefGoogle ScholarPubMed
Capron, A., Biguet, J., Vernes, A. & Afchain, D. (1968). Structure antigénique des helminthes. Aspects immunologiques des relations hôte-parasite. Pathologie et Biologie 16, 121–38.Google Scholar
Humphrey, J. H. & White, R. G. (1964). Immunology for students of medicine. (2nd ed.). Oxford: Blackwell.Google Scholar
Peres, J. N. (1944). Söbre a presença de anticorpos heterogeneticos na esquistossomose de Manson. Revista Brasileira de Biologia 4, 401–4.Google Scholar
Smithers, S. R. & Terry, R. J. (1965). The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms. Parasitology 55, 695–700.CrossRefGoogle ScholarPubMed
Smithers, S. R. & Terry, R. J. (1967). Resistance to experimental infection with Schistosoma mansoni in rhesus monkeys induced by the transfer of adult worms. Transactions of the Royal Society of Tropical Medicine and Hygiene 61, 517–33.CrossRefGoogle ScholarPubMed
Smithers, S. R. & Terry, R. J. (1969 a). Immunity in schistosomiasis. Annals of the New York Academy of Sciences 160, Art. 2, 826–40.CrossRefGoogle ScholarPubMed
Smithers, S. R. & Terry, R. J. (1969 b). The immunology of schistosomiasis. In Advances in Parasitology (ed. Ben, Dawes) 7, 41–93. London and New York: Academic Press.Google Scholar
Smithers, S. R., Terry, R. J. & Hockley, D. J. (1969). Host antigens in schistosomiasis. Proceedings of the Royal Society Ser. B 171, 483–94.Google ScholarPubMed
Uhr, J. W. & Moller, G. (1968). Regulatory effect of antibody on the immune response. In Advances in Immunology (ed. Dixon, F. J. and Kunkel, H. G.) 8, 81–127. New York and London: Academic Press.Google Scholar