Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-848d4c4894-pftt2 Total loading time: 0 Render date: 2024-05-31T19:29:32.688Z Has data issue: false hasContentIssue false

Chapter 19 - Management of Issues Associated with Female Contraceptives

Drug–Drug Interactions

from Section 2A - Sexual and Reproductive Healthcare: Contraception

Published online by Cambridge University Press:  16 January 2024

By
Katarina Sedlecky ,
Gabriele S. Merki-Feld  and
Frans J. M. E. Roumen
Edited by
Johannes Bitzer  and
Tahir A. Mahmood
Johannes Bitzer
Affiliation:
University Women's Hospital, Basel
Tahir A. Mahmood
Affiliation:
Victoria Hospital, Kirkcaldy
Get access

Summary

Assessing the safety and efficacy of hormonal contraception involves examining possible interactions between contraceptives and concomitant medications or herbal supplements. The effects of hormonal contraception may be altered by changes in the resorption, metabolism, secretion or activity of sex hormones. Hormonal contraception, on the other hand, can affect the metabolism or therapeutic effect of drugs.

Type
Chapter
Information
Textbook of Contraception, Sexual and Reproductive Health , pp. 131 - 139
Publisher: Cambridge University Press
Print publication year: 2024

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Pohl, O, Osterloh, I, Lecomte, V, Gotteland, JP. Changes in gastric pH and in pharmacokinetics of ulipristal acetate: A drug–drug interaction study using the proton pump inhibitor esomeprazole. Int J Clin Pharmacol Ther. 2013;51(1):26–33.CrossRefGoogle ScholarPubMed
Simmons, KB, Kumar, N, Plagianos, M et al. Effects of concurrent vaginal miconazole treatment on the absorption and exposure of Nestorone® (segesterone acetate) and ethinyl estradiol delivered from a contraceptive vaginal ring: A randomized, crossover drug–drug interaction study. Contraception. 2018;97(3):270–6.CrossRefGoogle ScholarPubMed
Reimers, A, Brodtkorb, E, Sabers, A. Interactions between hormonal contraception and antiepileptic drugs: Clinical and mechanistic considerations. Seizure. 2015;28:66–70.CrossRefGoogle ScholarPubMed
Lee, CR. Drug interactions and hormonal contraception. Trends in Urology Gynaecology & Sexual Health. 2009:23–6.CrossRefGoogle Scholar
US Food and Drug Administration. Drug development and drug interactions: Table of substrates, inhibitors and inducers. http://bit.ly/3JpjGL7.Google Scholar
Reddy, DS. Clinical pharmacokinetic interactions between antiepileptic drugs and hormonal contraceptives. Expert Rev Clin Pharmacol. 2010;3(2):183–92.CrossRefGoogle ScholarPubMed
Herzog, AG, Mandle, HB, Cahill, KE, Fowler, KM, Hauser, WA. Differential impact of contraceptive methods on seizures varies by antiepileptic drug category: Findings of the Epilepsy Birth Control Registry. Epilepsy Behav. 2016;60:112–17.CrossRefGoogle ScholarPubMed
Berry-Bibee, EN, Kim, MJ, Simmons, KB et al. Drug interactions between hormonal contraceptives and psychotropic drugs: A systematic review. Contraception. 2016;94(6):650–67.CrossRefGoogle ScholarPubMed
Schoretsanitis, G, Kane, JM, de Leon, J. Adding oral contraceptives to clozapine may require halving the clozapine dose: A new case and a literature review. J Clin Psychopharmacol. 2020;40(3):308–10.CrossRefGoogle Scholar
Ti, A, Stone, RH, Whiteman, M, Curtis, KM. Safety and effectiveness of hormonal contraception for women who use opioids: A systematic review. Contraception. 2019;100(6):480–3.CrossRefGoogle ScholarPubMed
Qian, Y, Gurley, BJ, Markowitz, JS. The potential for pharmacokinetic interactions between cannabis products and conventional medications. J Clin Psychopharmacol. 2019;39(5):462–71.CrossRefGoogle ScholarPubMed
Robertson, P, DeCory, HH, Madan, A, Parkinson, A. In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil. Drug Metab Dispos. 2000;28(6):664–71.Google ScholarPubMed
Robertson, P, Jr, Hellriegel, ET, Arora, S, Nelson, M. Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers. Clin Pharmacol Ther. 2002;71(1):46–56.CrossRefGoogle ScholarPubMed
Simmons, KB, Haddad, LB, Nanda, K, Curtis, KM. Drug interactions between rifamycin antibiotics and hormonal contraception: A systematic review. BJOG. 2018;125(7):804–11.CrossRefGoogle ScholarPubMed
Simmons, KB, Haddad, LB, Nanda, K, Curtis, KM. Drug interactions between non-rifamycin antibiotics and hormonal contraception: A systematic review. Am J Obstet Gynecol. 2018;218(1):88–97.e14.CrossRefGoogle ScholarPubMed
Dogterom, P, van den Heuvel, MW, Thomsen, T. Absence of pharmacokinetic interactions of the combined contraceptive vaginal ring NuvaRing with oral amoxicillin or doxycycline in two randomised trials. Clin Pharmacokinet. 2005;44(4):429–38.CrossRefGoogle ScholarPubMed
Hendrix, CW, Jackson, KA, Whitmore, E et al. The effect of isotretinoin on the pharmacokinetics and pharmacodynamics of ethinyl estradiol and norethindrone. Clin Pharmacol Ther. 2004;75(5):464–75.CrossRefGoogle ScholarPubMed
Bailard, N, Rebello, E. Aprepitant and fosaprepitant decrease the effectiveness of hormonal contraceptives. Br J Clin Pharmacol. 2018;84(3):602–3.CrossRefGoogle ScholarPubMed
Van Giersbergen, PL, Halabi, A, Dingemanse, J. Pharmacokinetic interaction between bosentan and the oral contraceptives norethisterone and ethinyl estradiol. Int J Clin Pharmacol Ther. 2006;44(3):113–18.Google ScholarPubMed
Zhang, N, Shon, J, Kim, MJ et al. Role of CYP3A in oral contraceptives clearance. Clin Transl Sci. 2018;11(3):251–60.CrossRefGoogle ScholarPubMed
Verhoeven, CH, van den Heuvel, MW, Mulders, TM, Dieben, TO. The contraceptive vaginal ring, NuvaRing, and antimycotic co-medication. Contraception. 2004;69(2):129–32.Google ScholarPubMed
Ezuruike, U, Humphries, H, Dickins, M et al. Risk-benefit assessment of ethinylestradiol using a physiologically based pharmacokinetic modeling approach. Clin Pharmacol Ther. 2018;104(6):1229–39.CrossRefGoogle ScholarPubMed
Catalano, PM, Blank, H. Griseofulvin–oral contraceptive interaction. Arch Dermatol. 1985;121(11):1381–7.CrossRefGoogle ScholarPubMed
Berry-Bibee, EN, Kim, MJ, Tepper, NK, Riley, HE, Curtis, KM. Co-administration of St. John’s wort and hormonal contraceptives: A systematic review. Contraception. 2016;94(6):668–77.CrossRefGoogle ScholarPubMed
Edelman, AB, Jensen, JT, McCrimmon, S et al. Combined oral contraceptive interference with the ability of ulipristal acetate to delay ovulation: A prospective cohort study. Contraception. 2018;98(6):463–6.CrossRefGoogle ScholarPubMed
Cameron, ST, Berger, C, Michie, L, Klipping, C, Gemzell-Danielsson, K. The effects on ovarian activity of ulipristal acetate when ‘quickstarting’ a combined oral contraceptive pill: A prospective, randomized, double-blind parallel-arm, placebo-controlled study. Hum Reprod. 2015;30(7):1566–72.CrossRefGoogle Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×