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Is it worth while changing clinically stable schizophrenic out-patients with mild to moderate residual symptoms and/or side effects from conventional to atypical antipsychotics? A prospective, randomised study with olanzapine

Published online by Cambridge University Press:  16 April 2020

Björn Appelberg ,
Katinka Tuisku  and
Grigori Joffe
Björn Appelberg*
Affiliation:
Department of Psychiatry, Helsinki University Central Hospital, POB 590, 00029 Hus, Finland
Katinka Tuisku
Affiliation:
Department of Psychiatry, Helsinki University Central Hospital, POB 590, 00029 Hus, Finland
Grigori Joffe
Affiliation:
Psychiatric Hospital of Kellokoski, Finland
*
*Corresponding author. Email address: bjorn.appelberg@helsinki.fi
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Abstract

Fifty clinically stable, schizophrenic outpatients, suffering from residual schizophrenic symptoms and/or neurological side effects, were randomised to either continue their conventional neuroleptic(s) or change it to olanzapine. After 12 weeks patients on olanzapine exhibited significant improvement in neurological side effects and psychotic symptomatology as compared to patients on conventional antipsychotics.

Keywords

SchizophreniaOutpatientsRandomised trialAtypical antipsychoticsOlanzapine
Type
Rapid communication
Information
European Psychiatry , Volume 19 , Issue 8 , December 2004 , pp. 516 - 518
Copyright
Copyright © European Psychiatric Association 2004

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