Skip to main content

Advertisement

Log in

Cost-Effectiveness of Arthroplasty Management in Hip and Knee Osteoarthritis: a Quality Review of the Literature

  • Osteoarthritis (T Appleton, Section Editor)
  • Published:
Current Treatment Options in Rheumatology Aims and scope Submit manuscript

Abstract

Purpose of review

Musculoskeletal disorders are a leading contributor to healthcare resource use and reduced quality of life, particularly in osteoarthritis of the hip/knee. Consequently, the volume of arthroplasty procedures continues to rise and there is a critical need to identify interventions that provide value-based care. Economic evaluations that assess both cost and health outcomes simultaneously allow clinicians and policymakers to make informed decisions regarding cost-effective interventions. The purpose of this review was to summarize and evaluate the methodological quality of economic evaluations of hip/knee interventions in arthroplasty.

Recent findings

We identified 384 studies. Two-thirds did not meet the criteria for full economic evaluations (compared costs independently). Several studies (28%) inappropriately concluded interventions were cost-effective. Using a validated quality assessment tool, we determined the quality of full economic evaluations in hip/knee arthroplasty is generally good; however, important areas for quality improvement are related to reporting perspective, costing methodology, and funding.

Summary

Value-based care in arthroplasty relies on the quality of the literature. Although the quality is generally good, few full economic evaluations are published in arthroplasty. Yet, these are necessary to appropriately infer intervention cost-effectiveness. Unfortunately, clinical decisions continue to be made using highly cited low-quality or partial economic evaluations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Briggs AM, Cross MJ, Hoy DG, Sanchez-Riera L, Blyth FM, Woolf AD, et al. Musculoskeletal health conditions represent a global threat to healthy aging: a report for the 2015 World Health Organization world report on ageing and health. The Gerontologist. 2016;56(Suppl 2):S243–55. https://doi.org/10.1093/geront/gnw002.

    Article  PubMed  Google Scholar 

  2. Vos T, Allan C, Arora M, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet (London, England). 2016;388(10053):1545–602. https://doi.org/10.1016/s0140-6736(16)31678-6.

    Article  Google Scholar 

  3. Dieleman JL, Cao J, Chapin A, Chen C, Li Z, Liu A, et al. US health care spending by payer and health condition, 1996-2016. JAMA. 2020;323(9):863–84. https://doi.org/10.1001/jama.2020.0734.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Losina E, Dervan EE, Paltiel AD, Dong Y, Wright RJ, Spindler KP, et al. Defining the value of future research to identify the preferred treatment of meniscal tear in the presence of knee osteoarthritis. PLoS One. 2015;10(6):e0130256. https://doi.org/10.1371/journal.pone.0130256.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73(7):1323–30. https://doi.org/10.1136/annrheumdis-2013-204763.

    Article  PubMed  Google Scholar 

  6. Kurtz SM, Ong KL, Lau E, Widmer M, Maravic M, Gómez-Barrena E, et al. International survey of primary and revision total knee replacement. Int Orthop. 2011;35(12):1783–9. https://doi.org/10.1007/s00264-011-1235-5.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Cram P, Lu X, Kates SL, Singh JA, Li Y, Wolf BR. Total knee arthroplasty volume, utilization, and outcomes among Medicare beneficiaries, 1991-2010. JAMA. 2012;308(12):1227–36. https://doi.org/10.1001/2012.jama.11153.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Hooper G, Lee AJ, Rothwell A, Frampton C. Current trends and projections in the utilisation rates of hip and knee replacement in New Zealand from 2001 to 2026. N Z Med J. 2014;127(1401):82–93.

    PubMed  Google Scholar 

  9. Sloan M, Premkumar A, Sheth NP. Projected volume of primary total joint arthroplasty in the U.S., 2014 to 2030. J Bone Joint Surg Am. 2018;100(17):1455–60. https://doi.org/10.2106/jbjs.17.01617.

    Article  PubMed  Google Scholar 

  10. Ackerman IN, Bohensky MA, Zomer E, Tacey M, Gorelik A, Brand CA, et al. The projected burden of primary total knee and hip replacement for osteoarthritis in Australia to the year 2030. BMC Musculoskelet Disord. 2019;20(1):90. https://doi.org/10.1186/s12891-019-2411-9.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Drummond MF, Sculpher MJ, Torrance GW, O’Brien BJ, Stoddart GL. Methods for the economic evaluation of health care programmes: Oxford University Press; 2005.

  12. Guidelines for the economic evaluation of health technologies: Canada. In: CADTH. Ottawa: 2017 Mar.

  13. Sanders GD, Neumann PJ, Basu A, Brock DW, Feeny D, Krahn M, et al. Recommendations for conduct, methodological practices, and reporting of cost-effectiveness analyses: second panel on cost-effectiveness in health and medicine. JAMA. 2016;316(10):1093–103. https://doi.org/10.1001/jama.2016.12195.

    Article  PubMed  Google Scholar 

  14. Daigle ME, Weinstein AM, Katz JN, Losina E. The cost-effectiveness of total joint arthroplasty: a systematic review of published literature. Best Pract Res Clin Rheumatol. 2012;26(5):649–58. https://doi.org/10.1016/j.berh.2012.07.013.

    Article  PubMed  Google Scholar 

  15. Kamaruzaman H, Kinghorn P, Oppong R. Cost-effectiveness of surgical interventions for the management of osteoarthritis: a systematic review of the literature. BMC Musculoskelet Disord. 2017;18(1):183. https://doi.org/10.1186/s12891-017-1540-2. A systematic review summarizing full economic evaluations in the surgical arthroplasty literature. Although there is no summary score for all studies using the Quality of Health Economics Studies (QHES) tool, individual QHES scores are provided for each study.

  16. Nwachukwu BU, Bozic KJ, Schairer WW, Bernstein JL, Jevsevar DS, Marx RG, et al. Current status of cost utility analyses in total joint arthroplasty: a systematic review. Clin Orthop Relat Res. 2015;473(5):1815–27. https://doi.org/10.1007/s11999-014-3964-4. A systematic review reporting the quality of cost-utility analyses for surgical arthroplasty interventions (excluding prophylaxis, rehabilitation, etc.) in the United States alone. The study reports a mean study quality of 86.4 on the Quality of Health Economics Studies (QHES) tool.

  17. Chiou CF, Hay JW, Wallace JF, Bloom BS, Neumann PJ, Sullivan SD, et al. Development and validation of a grading system for the quality of cost-effectiveness studies. Med Care. 2003;41(1):32–44. https://doi.org/10.1097/00005650-200301000-00007.

    Article  PubMed  Google Scholar 

  18. Ofman JJ, Sullivan SD, Neumann PJ, Chiou CF, Henning JM, Wade SW, et al. Examining the value and quality of health economic analyses: implications of utilizing the QHES. J Manag Care Pharm. 2003;9(1):53–61. https://doi.org/10.18553/jmcp.2003.9.1.53.

    Article  PubMed  Google Scholar 

  19. Gerkens S, Crott R, Cleemput I, Thissen JP, Closon MC, Horsmans Y, et al. Comparison of three instruments assessing the quality of economic evaluations: a practical exercise on economic evaluations of the surgical treatment of obesity. Int J Technol Assess Health Care. 2008;24(3):318–25. https://doi.org/10.1017/s0266462308080422.

    Article  PubMed  Google Scholar 

  20. Marshall DA, Donald F, Lacny S, Reid K, Bryant-Lukosius D, Carter N, et al. Assessing the quality of economic evaluations of clinical nurse specialists and nurse practitioners: a systematic review of cost-effectiveness. Nurs Plus Open. 2015;1:11–7. https://doi.org/10.1016/j.npls.2015.07.001.

    Article  Google Scholar 

  21. Viera AJ, Garrett JM. Understanding interobserver agreement: the kappa statistic. Fam Med. 2005;37(5):360–3.

    PubMed  Google Scholar 

  22. Spiegel BM, Targownik LE, Kanwal F, Derosa V, Dulai GS, Gralnek IM, et al. The quality of published health economic analyses in digestive diseases: a systematic review and quantitative appraisal. Gastroenterology. 2004;127(2):403–11. https://doi.org/10.1053/j.gastro.2004.04.020.

    Article  PubMed  Google Scholar 

  23. Abdel MP, Miller LE, Hanssen AD, Pagnano MW. Cost analysis of dual-mobility versus large femoral head constructs in revision total hip arthroplasty. J Arthroplast. 2019;34(2):260–4. https://doi.org/10.1016/j.arth.2018.09.085.

    Article  Google Scholar 

  24. Abdool-Carrim T, Adler H, Becker P, Carides M, Ginsberg J, Golele R, et al. The cost and benefit of prophylaxis against deep vein thrombosis in elective hip replacement. DVT/PE prophylaxis consensus forum. S Afr Med J. 1997;87(5):594–600.

    CAS  PubMed  Google Scholar 

  25. Adeyemi A, Trueman P. Economic burden of surgical site infections within the episode of care following joint replacement. J Orthop Surg Res. 2019;14(1):196. https://doi.org/10.1186/s13018-019-1224-8.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Agarwal N, Rao N, Mekheil M, Tancredi N, Oken J. Safety, efficacy and cost analysis of Rivaroxaban versus Fondaparinux for thromboprophylaxis after joint replacement at an inpatient rehabilitation facility. J Pharm Pharmacol. 2015;3:538–43. https://doi.org/10.17265/2328-2150/2015.11.006.

  27. Akindolire J, Morcos MW, Marsh JD, Howard JL, Lanting BA, Vasarhelyi EM. The economic impact of periprosthetic infection in total hip arthroplasty. Can J Surg. 2020;63(1):E52-e6. https://doi.org/10.1503/cjs.004219.

    Article  Google Scholar 

  28. Allen LR, Bonck MJ, Lofgren KL, Mayo KW, Mozaffari E. Low-molecular-weight heparin therapy for patients undergoing total knee replacement surgery: cost and outcomes. Hosp Pharm. 2003;38(9):833–40. https://doi.org/10.1177/001857870303800908.

    Article  Google Scholar 

  29. Alshryda S, Mason J, Sarda P, Nargol A, Cooke N, Ahmad H, et al. Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total hip replacement: a randomized controlled trial (TRANX-H). J Bone Joint Surg Am. 2013;95(21):1969–74. https://doi.org/10.2106/jbjs.L.00908.

    Article  PubMed  Google Scholar 

  30. Andreasen SE, Holm HB, Jorgensen M, Gromov K, Kjaersgaard-Andersen P, Husted H. Time-driven activity-based cost of fast-track total hip and knee arthroplasty. J Arthroplast. 2017;32(6):1747–55. https://doi.org/10.1016/j.arth.2016.12.040.

    Article  Google Scholar 

  31. Arana M, Harper L, Qin H, Mabrey J. Reducing length of stay, direct cost, and readmissions in total joint arthroplasty patients with an outcomes manager-led interprofessional team. Orthop Nurs. 2017;36(4):279–84. https://doi.org/10.1097/nor.0000000000000366.

    Article  PubMed  Google Scholar 

  32. Arterburn D, Wellman R, Westbrook E, Rutter C, Ross T, McCulloch D, et al. Introducing decision aids at group health was linked to sharply lower hip and knee surgery rates and costs. Health Aff (Project Hope). 2012;31(9):2094–104. https://doi.org/10.1377/hlthaff.2011.0686.

    Article  Google Scholar 

  33. Asche CV, Ren J, Kim M, Gordon K, McWhirter M, Kirkness CS, et al. Local infiltration for postsurgical analgesia following total hip arthroplasty: a comparison of liposomal bupivacaine to traditional bupivacaine. Curr Med Res Opin. 2017;33(7):1283–90. https://doi.org/10.1080/03007995.2017.1314262.

    Article  CAS  PubMed  Google Scholar 

  34. Ast MP, Mayman DJ, Su EP, Gonzalez Della Valle AM, Parks ML, Haas SB. The reduction of implant-related errors and waste in total knee arthroplasty using a novel, computer based, label and compatibility system. J Arthroplast. 2014;29(1):132–6. https://doi.org/10.1016/j.arth.2013.03.013.

    Article  Google Scholar 

  35. Aydin BK, Durgut F, Erkocak OF, Acar MA. Other benefits of intra-articular injection of tranexamic acid in primary total knee arthroplasty apart from reducing blood transfusion rates. Joint Dis Relat Surg. 2017;28(1):25–9. https://doi.org/10.5606/ehc.2017.52725.

    Article  Google Scholar 

  36. Barlow BT, McLawhorn AS, Westrich GH. The cost-effectiveness of dual mobility implants for primary total hip arthroplasty: a computer-based cost-utility model. J Bone Joint Surg Am. 2017;99(9):768–77. https://doi.org/10.2106/jbjs.16.00109.A full economic evaluation of a Markov model comparing dual-mobility to conventional implants in total hip arthroplasty that scored a perfect 100 on the Quality of Health Economics Studies (QHES) tool. The paper provides a great reference for researchers when designing studies and drafting manuscripts or for critical appraisal of studies.

  37. Barrack RL. The economics of revision arthroplasty. Orthopedics. 1995;18(9):874–5.

    CAS  PubMed  Google Scholar 

  38. Barrack RL. Economics of the infected total knee replacement. Orthopedics. 1996;19(9):780–2.

    CAS  PubMed  Google Scholar 

  39. Barrack RL. The evolving cost spectrum of revision hip arthroplasty. Orthopedics. 1999;22(9):865–6.

    CAS  PubMed  Google Scholar 

  40. Barrack RL, Castro F, Guinn S. Cost of implanting a cemented versus cementless femoral stem. J Arthroplast. 1996;11(4):373–6. https://doi.org/10.1016/s0883-5403(96)80025-8.

    Article  CAS  Google Scholar 

  41. Barrack RL, Hoffman GJ, Tejeiro WV, Carpenter LJ Jr. Surgeon work input and risk in primary versus revision total joint arthroplasty. J Arthroplast. 1995;10(3):281–6. https://doi.org/10.1016/s0883-5403(05)80175-5.

    Article  CAS  Google Scholar 

  42. Barrack RL, Ruh EL, Williams BM, Ford AD, Foreman K, Nunley RM. Patient specific cutting blocks are currently of no proven value. J Bone Joint Surg Br Vol. 2012;94(11 Suppl A):95–9. https://doi.org/10.1302/0301-620x.94b11.30834.

    Article  CAS  Google Scholar 

  43. Batsis JA, Naessens JM, Keegan MT, Huddleston PM, Wagie AE, Huddleston JM. Resource utilization of total knee arthroplasty patients cared for on specialty orthopedic surgery units. J Hosp Med. 2008;3(3):218–27. https://doi.org/10.1002/jhm.299.

    Article  PubMed  Google Scholar 

  44. Baxter K, Bevan G. An economic model to estimate the relative costs over 20 years of different hip prostheses. J Epidemiol Community Health. 1999;53(9):542–7. https://doi.org/10.1136/jech.53.9.542.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Beard DJ, Davies LJ, Cook JA, MacLennan G, Price A, Kent S, et al. The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled trial. Lancet (London, England). 2019;394(10200):746–56. https://doi.org/10.1016/s0140-6736(19)31281-4.

    Article  Google Scholar 

  46. Bedair H, Cha TD, Hansen VJ. Economic benefit to society at large of total knee arthroplasty in younger patients: a Markov analysis. J Bone Joint Surg Am. 2014;96(2):119–26. https://doi.org/10.2106/jbjs.L.01736.

    Article  PubMed  Google Scholar 

  47. Bedair H, Yang J, Dwyer MK, McCarthy JC. Preoperative erythropoietin alpha reduces postoperative transfusions in THA and TKA but may not be cost-effective. Clin Orthop Relat Res. 2015;473(2):590–6. https://doi.org/10.1007/s11999-014-3819-z.

    Article  PubMed  Google Scholar 

  48. Bell GK, Goldhaber SZ. Cost implications of low molecular weight heparins as prophylaxis following total hip and knee replacement. Vasc Med (London, England). 2001;6(1):23–9.

    CAS  Google Scholar 

  49. Benninger E, Zingg PO, Kamath AF, Dora C. Cost analysis of fresh-frozen femoral head allografts: is it worthwhile to run a bone bank? Bone Joint J. 2014;96-b(10):1307–11. https://doi.org/10.1302/0301-620x.96b10.33486.

    Article  CAS  PubMed  Google Scholar 

  50. Berend KR, Lombardi AV Jr, Adams JB. Simultaneous vs staged cementless bilateral total hip arthroplasty: perioperative risk comparison. J Arthroplast. 2007;22(6 Suppl 2):111–5. https://doi.org/10.1016/j.arth.2007.03.043.

    Article  Google Scholar 

  51. Bergqvist D, Lindgren B, Matzsch T. Comparison of the cost of preventing postoperative deep vein thrombosis with either unfractionated or low molecular weight heparin. Br J Surg. 1996;83(11):1548–52. https://doi.org/10.1002/bjs.1800831117.

    Article  CAS  PubMed  Google Scholar 

  52. Bernasek TL, Burris RB, Fujii H, Levering MF, Polikandriotis JA, Patterson JJ. Effect on blood loss and cost-effectiveness of pain cocktails, platelet-rich plasma, or fibrin sealant after total knee arthroplasty. J Arthroplast. 2012;27(8):1448–51. https://doi.org/10.1016/j.arth.2012.02.018.

    Article  Google Scholar 

  53. Bilgili MG, Ercin E, Peker G, Kural C, Basaran SH, Duramaz A, et al. Efficiency and cost analysis of cell saver auto transfusion system in total knee arthroplasty. Balk Med J. 2014;31(2):149–53. https://doi.org/10.5152/balkanmedj.2014.13267.

    Article  Google Scholar 

  54. Billote DB, Glisson SN, Green D, Wixson RL. A prospective, randomized study of preoperative autologous donation for hip replacement surgery. J Bone Joint Surg Am. 2002;84(8):1299–304. https://doi.org/10.2106/00004623-200208000-00002.

    Article  PubMed  Google Scholar 

  55. Bjerke-Kroll BT, Sculco PK, McLawhorn AS, Christ AB, Gladnick BP, Mayman DJ. The increased total cost associated with post-operative drains in total hip and knee arthroplasty. J Arthroplast. 2014;29(5):895–9. https://doi.org/10.1016/j.arth.2013.10.027.

    Article  Google Scholar 

  56. Blin P, Samama CM, Sautet A, Benichou J, Lignot-Maleyran S, Lamarque S, et al. Comparative effectiveness of direct oral anticoagulants versus low-molecular weight heparins for the prevention of venous thromboembolism after total hip or knee replacement: a nationwide database cohort study. Pharmacol Res. 2019;141:201–7. https://doi.org/10.1016/j.phrs.2018.12.018.

    Article  CAS  PubMed  Google Scholar 

  57. Blumberg N, Kirkley SA, Heal JM. A cost analysis of autologous and allogeneic transfusions in hip-replacement surgery. Am J Surg. 1996;171(3):324–30. https://doi.org/10.1016/s0002-9610(97)89635-3.

    Article  CAS  PubMed  Google Scholar 

  58. Boese CK, Gallo TJ, Weis M, Baker R, Plantikow CJ, Cooley B. Efficacy and cost-effectiveness of a blood salvage system in primary total knee arthroplasty‑a retrospective match-controlled chart review. Iowa Orthop J. 2011;31:78–82.

    PubMed  PubMed Central  Google Scholar 

  59. Boese CK, Weis M, Phillips T, Lawton-Peters S, Gallo T, Centeno L. The efficacy of continuous passive motion after total knee arthroplasty: a comparison of three protocols. J Arthroplast. 2014;29(6):1158–62. https://doi.org/10.1016/j.arth.2013.12.005.

    Article  Google Scholar 

  60. Bolz KM, Crawford RW, Donnelly B, Whitehouse SL, Graves N. The cost-effectiveness of routine follow-up after primary total hip arthroplasty. J Arthroplast. 2010;25(2):191–6. https://doi.org/10.1016/j.arth.2008.12.009.

    Article  Google Scholar 

  61. Botteman MF, Caprini J, Stephens JM, Nadipelli V, Bell CF, Pashos CL, et al. Results of an economic model to assess the cost-effectiveness of enoxaparin, a low-molecular-weight heparin, versus warfarin for the prophylaxis of deep vein thrombosis and associated long-term complications in total hip replacement surgery in the United States. Clin Ther. 2002;24(11):1960–86; discussion 38. https://doi.org/10.1016/s0149-2918(02)80091-1.

    Article  CAS  PubMed  Google Scholar 

  62. Bourne RB, Rorabeck CH, Laupacis A, Feeny D, Wong C, Tugwell P, et al. A randomized clinical trial comparing cemented to cementless total hip replacement in 250 osteoarthritic patients: the impact on health related quality of life and cost effectiveness. Iowa Orthop J. 1994;14:108–14.

    CAS  PubMed  PubMed Central  Google Scholar 

  63. Boylan MR, Riesgo AM, Paulino CB, Sheskier SC. Does Total ankle arthroplasty belong in the comprehensive care for joint replacement? J Foot Ankle Surg. 2018;57(1):69–73. https://doi.org/10.1053/j.jfas.2017.08.008.

    Article  PubMed  Google Scholar 

  64. Bozic KJ, Morshed S, Silverstein MD, Rubash HE, Kahn JG. Use of cost-effectiveness analysis to evaluate new technologies in orthopaedics. The case of alternative bearing surfaces in total hip arthroplasty. J Bone Joint Surg Am. 2006;88(4):706–14. https://doi.org/10.2106/jbjs.E.00614.

    Article  PubMed  Google Scholar 

  65. Bozic KJ, Pui CM, Ludeman MJ, Vail TP, Silverstein MD. Do the potential benefits of metal-on-metal hip resurfacing justify the increased cost and risk of complications? Clin Orthop Relat Res. 2010;468(9):2301–12. https://doi.org/10.1007/s11999-010-1301-0.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Breeman S, Campbell M, Dakin H, Fiddian N, Fitzpatrick R, Grant A, et al. Patellar resurfacing in total knee replacement: five-year clinical and economic results of a large randomized controlled trial. J Bone Joint Surg Am. 2011;93(16):1473–81. https://doi.org/10.2106/jbjs.J.00725.

    Article  PubMed  Google Scholar 

  67. Breeman S, Campbell MK, Dakin H, Fiddian N, Fitzpatrick R, Grant A, et al. Five-year results of a randomised controlled trial comparing mobile and fixed bearings in total knee replacement. Bone Joint J. 2013;95-b(4):486–92. https://doi.org/10.1302/0301-620x.95b4.29454.

    Article  Google Scholar 

  68. Briggs A, Sculpher M, Dawson J, Fitzpatrick R, Murray D, Malchau H. The use of probabilistic decision models in technology assessment: the case of total hip replacement. Appl Health Econ Health Policy. 2004;3(2):79–89. https://doi.org/10.2165/00148365-200403020-00004.

    Article  PubMed  Google Scholar 

  69. Brothers TE, Frank CE, Frank B, Robison JG, Elliott BM, Del Schutte H, et al. Is duplex venous surveillance worthwhile after arthroplasty? J Surg Res. 1997;67(1):72–8. https://doi.org/10.1006/jsre.1996.4962.

    Article  CAS  PubMed  Google Scholar 

  70. Brown ML, Plate JF, Holst DC, Bracey DN, Bullock MW, Lang JE. A retrospective analysis of the merits and challenges associated with simultaneous bilateral THA using the direct anterior approach. Hip Int. 2017;27(2):169–74. https://doi.org/10.5301/hipint.5000449.

    Article  PubMed  Google Scholar 

  71. Browne JA, Dempsey IJ, Novicoff W, Wanchek T. When would a metal-backed component become cost-effective over an all-polyethylene Tibia in total knee arthroplasty? Am J Orthop (Belle Mead, NJ). 2018;47(6). https://doi.org/10.12788/ajo.2018.0039.

  72. Brunenberg DE, van Steyn MJ, Sluimer JC, Bekebrede LL, Bulstra SK, Joore MA. Joint recovery programme versus usual care: an economic evaluation of a clinical pathway for joint replacement surgery. Med Care. 2005;43(10):1018–26. https://doi.org/10.1097/01.mlr.0000178266.75744.35.

    Article  PubMed  Google Scholar 

  73. Bulthuis Y, Mohammad S, Braakman-Jansen LM, Drossaers-Bakker KW, van de Laar MA. Cost-effectiveness of intensive exercise therapy directly following hospital discharge in patients with arthritis: results of a randomized controlled clinical trial. Arthritis Rheum. 2008;59(2):247–54. https://doi.org/10.1002/art.23332.

    Article  PubMed  Google Scholar 

  74. Callaghan JJ, Liu SS. Ceramic on crosslinked polyethylene in total hip replacement: any better than metal on crosslinked polyethylene? Iowa Orthop J. 2009;29:1–4.

    PubMed  PubMed Central  Google Scholar 

  75. Capra R, Bini SA, Bowden DE, Etter K, Callahan M, Smith RT, et al. Implementing a perioperative efficiency initiative for orthopedic surgery instrumentation at an academic center: a comparative before-and-after study. Medicine. 2019;98(7):e14338. https://doi.org/10.1097/md.0000000000014338.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Caprini JA, Arcelus JI, Kudraa JC, Sehgal LR, Oyslender M, Maksimovic D, et al. Cost-effectiveness of venous thromboembolism prophylaxis after total hip replacement. Phlebology. 2002;17(3–4):126–33. https://doi.org/10.1177/026835550201700309.

    Article  Google Scholar 

  77. Chan VWK, Chan PK, Chiu KY, Yan CH, Ng FY. Does barbed suture lower cost and improve outcome in total knee arthroplasty? A randomized controlled trial. J Arthroplast. 2017;32(5):1474–7. https://doi.org/10.1016/j.arth.2016.12.015.

    Article  Google Scholar 

  78. Chang P, Okamoto M, Chen J, Frame D. Cost-effectiveness analysis of ondansetron and prochlorperazine for the prevention of postoperative nausea and vomiting. J Manag Care Pharm. 2005;11(4):317–21. https://doi.org/10.18553/jmcp.2005.11.4.317.

    Article  PubMed  Google Scholar 

  79. Chawla H, Nwachukwu BU, van der List JP, Eggman AA, Pearle AD, Ghomrawi HM. Cost effectiveness of patellofemoral versus total knee arthroplasty in younger patients. Bone Joint J. 2017;99-b(8):1028–36. https://doi.org/10.1302/0301-620x.99b8.Bjj-2016-1032.R1.

    Article  Google Scholar 

  80. Chen JJ, Frame DG, White TJ. Efficacy of ondansetron and prochlorperazine for the prevention of postoperative nausea and vomiting after total hip replacement or total knee replacement procedures: a randomized, double-blind, comparative trial. Arch Intern Med. 1998;158(19):2124–8. https://doi.org/10.1001/archinte.158.19.2124.

    Article  CAS  PubMed  Google Scholar 

  81. Chen JY, Lo NN, Jiang L, Chong HC, Tay DK, Chin PL, et al. Simultaneous versus staged bilateral unicompartmental knee replacement. Bone Joint J. 2013;95-b(6):788–92. https://doi.org/10.1302/0301-620x.95b6.30440.

    Article  Google Scholar 

  82. Chi D, Mariano ER, Memtsoudis SG, Baker LC, Sun EC. Regional Anesthesia and readmission rates after Total knee arthroplasty. Anesth Analg. 2019;128(6):1319–27. https://doi.org/10.1213/ane.0000000000003830.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Chimento GF, Huff T, Ochsner JL Jr, Meyer M, Brandner L, Babin S. An evaluation of the use of topical tranexamic acid in total knee arthroplasty. J Arthroplast. 2013;28(8 Suppl):74–7. https://doi.org/10.1016/j.arth.2013.06.037.

    Article  Google Scholar 

  84. Chow J, Fitch DA. In-hospital costs for total hip replacement performed using the supercapsular percutaneously-assisted total hip replacement surgical technique. Int Orthop. 2017;41(6):1119–23. https://doi.org/10.1007/s00264-016-3327-8.

    Article  PubMed  Google Scholar 

  85. Clarke A, Pulikottil-Jacob R, Grove A, Freeman K, Mistry H, Tsertsvadze A, et al. Total hip replacement and surface replacement for the treatment of pain and disability resulting from end-stage arthritis of the hip (review of technology appraisal guidance 2 and 44): systematic review and economic evaluation. Health Technol Assess (Winchester, England). 2015;19(10):1–668, vii-viii. https://doi.org/10.3310/hta19100.

    Article  Google Scholar 

  86. Clement ND, Deehan DJ, Patton JT. Robot-assisted unicompartmental knee arthroplasty for patients with isolated medial compartment osteoarthritis is cost-effective: a markov decision analysis. Bone Joint J. 2019;101-b(9):1063–70. https://doi.org/10.1302/0301-620x.101b9.Bjj-2018-1658.R1.

    Article  Google Scholar 

  87. Clement RC, Kamath AF, Derman PB, Garino JP, Lee GC. Bipolar sealing in revision total hip arthroplasty for infection: efficacy and cost analysis. J Arthroplast. 2012;27(7):1376–81. https://doi.org/10.1016/j.arth.2011.11.016.

    Article  Google Scholar 

  88. Cohen EM, Marcaccio S, Goodman AD, Lemme NJ, Limbird R. Efficacy and cost-effectiveness of topical vancomycin powder in primary Cementless Total hip arthroplasty. Orthopedics. 2019;42(5):e430–e6. https://doi.org/10.3928/01477447-20190321-05.

    Article  PubMed  Google Scholar 

  89. Colwell CW, Froimson MI, Mont MA, Ritter MA, Trousdale RT, Buehler KC, et al. Cost-effectiveness of venous thromboembolism prophylaxis with a new mobile device after total hip arthroplasty. J Arthroplast. 2012;27(8):1513–7.e1. https://doi.org/10.1016/j.arth.2012.03.024.

    Article  Google Scholar 

  90. Colwell CW Jr, Morris BA. Patient-controlled analgesia compared with intramuscular injection of analgesics for the management of pain after an orthopaedic procedure. J Bone Joint Surg Am. 1995;77(5):726–33. https://doi.org/10.2106/00004623-199505000-00009.

    Article  PubMed  Google Scholar 

  91. Confalonieri N, Manzotti A, Pullen C. Navigated shorter incision or smaller implant in knee arthritis? Clin Orthop Relat Res. 2007;463:63–7. https://doi.org/10.1097/BLO.0b013e31811f3a30.

    Article  CAS  PubMed  Google Scholar 

  92. Cool CL, Needham KA, Khlopas A, Mont MA. Revision analysis of robotic arm-assisted and manual Unicompartmental knee arthroplasty. J Arthroplast. 2019;34(5):926–31. https://doi.org/10.1016/j.arth.2019.01.018.

    Article  Google Scholar 

  93. Corman S, Shah N, Dagenais S. Medication, equipment, and supply costs for common interventions providing extended post-surgical analgesia following total knee arthroplasty in US hospitals. J Med Econ. 2018;21(1):11–8. https://doi.org/10.1080/13696998.2017.1371031.

    Article  PubMed  Google Scholar 

  94. Courtney PM, Darrith B, Bohl DD, Frisch NB, Della Valle CJ. Reconsidering the affordable care Act's restrictions on physician-owned hospitals: analysis of CMS data on Total hip and knee arthroplasty. J Bone Joint Surg Am. 2017;99(22):1888–94. https://doi.org/10.2106/jbjs.17.00203.

    Article  PubMed  Google Scholar 

  95. Courville XF, Tomek IM, Kirkland KB, Birhle M, Kantor SR, Finlayson SR. Cost-effectiveness of preoperative nasal mupirocin treatment in preventing surgical site infection in patients undergoing total hip and knee arthroplasty: a cost-effectiveness analysis. Infect Control Hosp Epidemiol. 2012;33(2):152–9. https://doi.org/10.1086/663704.

    Article  PubMed  Google Scholar 

  96. Dahl OE, Pleil AM. Investment in prolonged thromboprophylaxis with dalteparin improves clinical outcomes after hip replacement. J Thromb Haemost. 2003;1(5):896–906. https://doi.org/10.1046/j.1538-7836.2003.00236.x.

    Article  CAS  PubMed  Google Scholar 

  97. Dakin H, Gray A, Fitzpatrick R, Maclennan G, Murray D. Rationing of total knee replacement: a cost-effectiveness analysis on a large trial data set. BMJ Open. 2012;2(1):e000332. https://doi.org/10.1136/bmjopen-2011-000332.

    Article  PubMed  PubMed Central  Google Scholar 

  98. Davies DM, Johnston DW, Beaupre LA, Lier DA. Effect of adjunctive range-of-motion therapy after primary total knee arthroplasty on the use of health services after hospital discharge. Can J Surg. 2003;46(1):30–6.

    PubMed  PubMed Central  Google Scholar 

  99. Davies LM, Richardson GA, Cohen AT. Economic evaluation of enoxaparin as postdischarge prophylaxis for deep vein thrombosis (DVT) in elective hip surgery. Value Health. 2000;3(6):397–406. https://doi.org/10.1046/j.1524-4733.2000.36005.x.

    Article  CAS  PubMed  Google Scholar 

  100. de Verteuil R, Imamura M, Zhu S, Glazener C, Fraser C, Munro N, et al. A systematic review of the clinical effectiveness and cost-effectiveness and economic modelling of minimal incision total hip replacement approaches in the management of arthritic disease of the hip. Health Technol Assess (Winchester, England). 2008;12(26):iii–v, ix-223. https://doi.org/10.3310/hta12260.

  101. DeHaan AM, Adams JR, DeHart ML, Huff TW. Patient-specific versus conventional instrumentation for total knee arthroplasty: peri-operative and cost differences. J Arthroplast. 2014;29(11):2065–9. https://doi.org/10.1016/j.arth.2014.06.019.

    Article  Google Scholar 

  102. Demeere JL, Merckx C, Demeere N. Cost minimisation and cost effectiveness in anaesthesia for total hip replacement surgery, in Belgium? A study comparing three general anaesthesia techniques. Acta Anaesthesiol Belg. 2006;57(2):145–51.

    PubMed  Google Scholar 

  103. Demos HA, Lin ZX, Barfield WR, Wilson SH, Robertson DC, Pellegrini VD Jr. Process improvement project using tranexamic acid is cost-effective in reducing blood loss and transfusions after Total hip and Total knee arthroplasty. J Arthroplast. 2017;32(8):2375–80. https://doi.org/10.1016/j.arth.2017.02.068.

    Article  Google Scholar 

  104. Derman PB, Kamath AF, Lee GC. Saline-coupled bipolar sealing in revision total knee arthroplasty for infection. Am J Orthop (Belle Mead, NJ). 2013;42(9):407–11.

    Google Scholar 

  105. Detournay B, Planes A, Vochelle N, Fagnani F. Cost effectiveness of a low-molecular-weight heparin in prolonged prophylaxis against deep vein thrombosis after total hip replacement. PharmacoEconomics. 1998;13(1 Pt 1):81–9. https://doi.org/10.2165/00019053-199813010-00008.

    Article  CAS  PubMed  Google Scholar 

  106. Di Tanna GL, Ferro S, Cipriani F, Bordini B, Stea S, Toni A, et al. Modeling the cost-effectiveness for cement-less and hybrid prosthesis in total hip replacement in Emilia Romagna, Italy. J Surg Res. 2011;169(2):227–33. https://doi.org/10.1016/j.jss.2009.10.031.

    Article  PubMed  Google Scholar 

  107. Diamantopoulos A, Lees M, Wells PS, Forster F, Ananthapavan J, McDonald H. Cost-effectiveness of rivaroxaban versus enoxaparin for the prevention of postsurgical venous thromboembolism in Canada. Thromb Haemost. 2010;104(4):760–70. https://doi.org/10.1160/th10-01-0071.

    Article  CAS  PubMed  Google Scholar 

  108. D'Lima DD, Venn-Watson EJ, Tripuraneni P, Colwell CW. Indomethacin versus radiation therapy for heterotopic ossification after hip arthroplasty. Orthopedics. 2001;24(12):1139–43.

    CAS  PubMed  Google Scholar 

  109. Dobosz B, Dutka J, Dutka L, Maleta P. Clinical and cost effectiveness-related aspects of retransfusion in total hip and knee arthroplasty. Ortop Traumatol Rehabil. 2012;14(5):421–8. https://doi.org/10.5604/15093492.1016367.

    Article  PubMed  Google Scholar 

  110. Doman DM, Gerlinger TL. Total joint arthroplasty cost savings with a rapid recovery protocol in a military medical center. Mil Med. 2012;177(1):64–9. https://doi.org/10.7205/milmed-d-11-00163.

    Article  PubMed  Google Scholar 

  111. Dong H, Buxton M. Early assessment of the likely cost-effectiveness of a new technology: a Markov model with probabilistic sensitivity analysis of computer-assisted total knee replacement. Int J Technol Assess Health Care. 2006;22(2):191–202. https://doi.org/10.1017/s0266462306051014.

    Article  PubMed  Google Scholar 

  112. Dramis A, Plewes J. Autologous blood transfusion after primary unilateral total knee replacement surgery. Acta Orthop Belg. 2006;72(1):15–7.

    PubMed  Google Scholar 

  113. Dranitsaris G, Kahn SR, Stumpo C, Paton TW, Martineau J, Smith R, et al. Pharmacoeconomic analysis of fondaparinux versus enoxaparin for the prevention of thromboembolic events in orthopedic surgery patients. Am J Cardiovasc Drugs. 2004;4(5):325–33. https://doi.org/10.2165/00129784-200404050-00005.

    Article  PubMed  Google Scholar 

  114. Drummond M, Aristides M, Davies L, Forbes C. Economic evaluation of standard heparin and enoxaparin for prophylaxis against deep vein thrombosis in elective hip surgery. Br J Surg. 1994;81(12):1742–6. https://doi.org/10.1002/bjs.1800811212.

    Article  CAS  PubMed  Google Scholar 

  115. Dudley TE, Gioe TJ, Sinner P, Mehle S. Registry outcomes of unicompartmental knee arthroplasty revisions. Clin Orthop Relat Res. 2008;466(7):1666–70. https://doi.org/10.1007/s11999-008-0279-3.

    Article  PubMed  PubMed Central  Google Scholar 

  116. Duncan CM, Hall Long K, Warner DO, Hebl JR. The economic implications of a multimodal analgesic regimen for patients undergoing major orthopedic surgery: a comparative study of direct costs. Reg Anesth Pain Med. 2009;34(4):301–7. https://doi.org/10.1097/AAP.0b013e3181ac7f86.

    Article  PubMed  Google Scholar 

  117. Duncan CM, Moeschler SM, Horlocker TT, Hanssen AD, Hebl JR. A self-paired comparison of perioperative outcomes before and after implementation of a clinical pathway in patients undergoing total knee arthroplasty. Reg Anesth Pain Med. 2013;38(6):533–8. https://doi.org/10.1097/aap.0000000000000014.

    Article  PubMed  Google Scholar 

  118. Duran A, Sengupta N, Diamantopoulos A, Forster F, Kwong L, Lees M. Cost and outcomes associated with rivaroxaban vs enoxaparin for the prevention of postsurgical venous thromboembolism from a US payer’s perspective. J Med Econ. 2011;14(6):824–34. https://doi.org/10.3111/13696998.2011.623203.

    Article  PubMed  Google Scholar 

  119. Duran A, Sengupta N, Diamantopoulos A, Forster F, Kwong L, Lees M. Cost effectiveness of rivaroxaban versus enoxaparin for prevention of post-surgical venous thromboembolism from a U.S. payer's perspective. PharmacoEconomics. 2012;30(2):87–101. https://doi.org/10.2165/11599370-000000000-00000.

    Article  PubMed  Google Scholar 

  120. Dutka J, Dutka L, Janiszewski M, Hajduk G. Cost analysis and sociomedical aspects of the conservative and surgical treatment of hip osteoarthritis. Ortop Traumatol Rehabil. 2008;10(6):537–46.

    PubMed  Google Scholar 

  121. Duwelius PJ, Brenner JS, Reyner DP, George JC. Cost effectiveness of minimally invasive Total hip arthroplasty. Semin Arthroplast. 2008;19(2):186–93. https://doi.org/10.1053/j.sart.2008.02.005.

    Article  Google Scholar 

  122. Duwelius PJ, Moller HS, Burkhart RL, Waller F, Wu Y, Grunkemeier GL. The economic impact of minimally invasive total hip arthroplasty. J Arthroplast. 2011;26(6):883–5. https://doi.org/10.1016/j.arth.2010.09.011.

    Article  Google Scholar 

  123. Edlin R, Tubeuf S, Achten J, Parsons N, Costa M. Cost-effectiveness of total hip arthroplasty versus resurfacing arthroplasty: economic evaluation alongside a clinical trial. BMJ Open. 2012;2(5). https://doi.org/10.1136/bmjopen-2012-001162.

  124. Eggers MD, Fang L, Lionberger DR. A comparison of wound closure techniques for total knee arthroplasty. J Arthroplast. 2011;26(8):1251–8.e1–4. https://doi.org/10.1016/j.arth.2011.02.029.

    Article  Google Scholar 

  125. Elawad A, Benoni G, Montgomery F, Hyddmark U, Persson U, Fredin H. Cost effectiveness of blood substitution in elective orthopedic operations. Acta Orthop Scand. 1991;62(5):435–9. https://doi.org/10.3109/17453679108996639.

    Article  CAS  PubMed  Google Scholar 

  126. Elbuluk AM, Slover J, Anoushiravani AA, Schwarzkopf R, Eftekhary N, Vigdorchik JM. The cost-effectiveness of dual mobility in a spinal deformity population with high risk of dislocation: a computer-based model. Bone Joint J. 2018;100-b(10):1297–302. https://doi.org/10.1302/0301-620x.100b10.Bjj-2017-1113.R3.

    Article  CAS  PubMed  Google Scholar 

  127. Elliott RA, Weatherly HL, Hawkins NS, Cranny G, Chambers D, Myers L, et al. An economic model for the prevention of MRSA infections after surgery: non-glycopeptide or glycopeptide antibiotic prophylaxis? Eur J Health Econ. 2010;11(1):57–66. https://doi.org/10.1007/s10198-009-0175-0.

    Article  PubMed  Google Scholar 

  128. Evans RL, Rubash HE, Albrecht SA. The efficacy of postoperative autotransfusion in total joint arthroplasty. Orthop Nurs. 1993;12(3):11–8. https://doi.org/10.1097/00006416-199305000-00004.

    Article  CAS  PubMed  Google Scholar 

  129. Farag E, Atim A, Ghosh R, Bauer M, Sreenivasalu T, Kot M, et al. Comparison of three techniques for ultrasound-guided femoral nerve catheter insertion: a randomized, blinded trial. Anesthesiology. 2014;121(2):239–48. https://doi.org/10.1097/aln.0000000000000262.

    Article  PubMed  Google Scholar 

  130. Faulkner A, Kennedy LG, Baxter K, Donovan J, Wilkinson M, Bevan G. Effectiveness of hip prostheses in primary total hip replacement: a critical review of evidence and an economic model. Health Technol Assess (Winchester, England). 1998;2(6):1–133.

    CAS  Google Scholar 

  131. Fawsitt CG, Thom HHZ, Hunt LP, Nemes S, Blom AW, Welton NJ, et al. Choice of prosthetic implant combinations in Total hip replacement: cost-effectiveness analysis using UK and Swedish hip joint registries data. Value Health. 2019;22(3):303–12. https://doi.org/10.1016/j.jval.2018.08.013.

    Article  PubMed  Google Scholar 

  132. Feng S, Yang Z, Sun JN, Zhu L, Wang S, Guo KJ, et al. Comparison of the therapeutic effect between the simultaneous and staged unicompartmental knee arthroplasty (UKA) for bilateral knee medial compartment arthritis. BMC Musculoskelet Disord. 2019;20(1):340. https://doi.org/10.1186/s12891-019-2724-8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  133. Fennema P, Heyse TJ, Uyl-de Groot CA. Cost-effectiveness and clinical implications of advanced bearings in total knee arthroplasty: a long-term modeling analysis. Int J Technol Assess Health Care. 2014;30(2):218–25. https://doi.org/10.1017/s0266462314000129.

    Article  PubMed  Google Scholar 

  134. Fernandes L, Roos EM, Overgaard S, Villadsen A, Søgaard R. Supervised neuromuscular exercise prior to hip and knee replacement: 12-month clinical effect and cost-utility analysis alongside a randomised controlled trial. BMC Musculoskelet Disord. 2017;18(1):5. https://doi.org/10.1186/s12891-016-1369-0. A full economic evaluation of an RCT comparing a supervised neuromuscular exercise program and preoperative educational package to the preoperative educational package alone prior to total joint arthroplasty that scored a perfect 100 on the Quality of Health Economics Studies (QHES) tool. The paper provides a great reference for researchers when designing studies and drafting manuscripts or for critical appraisal of studies.

  135. Fitzpatrick R, Shortall E, Sculpher M, Murray D, Morris R, Lodge M, et al. Primary total hip replacement surgery: a systematic review of outcomes and modelling of cost-effectiveness associated with different prostheses. Health Technol Assess (Winchester, England). 1998;2(20):1–64.

    CAS  Google Scholar 

  136. Fordham R, Skinner J, Wang X, Nolan J. The economic benefit of hip replacement: a 5-year follow-up of costs and outcomes in the Exeter Primary Outcomes Study. BMJ Open. 2012;2(3). https://doi.org/10.1136/bmjopen-2011-000752.

  137. Friedman RJ, Dunsworth GA. Cost analyses of extended prophylaxis with enoxaparin after hip arthroplasty. Clin Orthop Relat Res. 2000;370:171–82. https://doi.org/10.1097/00003086-200001000-00016.

    Article  Google Scholar 

  138. Friesen E, Lier D, Bachynsky J, Jacobs P. An economic comparison of enoxaparin and warfarin in the prevention of deep vein thrombosis after hip and knee replacement. Can J Hosp Pharm. 2002;55:128–35.

    Google Scholar 

  139. Froemke CC, Wang L, DeHart ML, Williamson RK, Ko LM, Duwelius PJ. Standardizing care and improving quality under a bundled payment initiative for Total joint arthroplasty. J Arthroplast. 2015;30(10):1676–82. https://doi.org/10.1016/j.arth.2015.04.028.

    Article  Google Scholar 

  140. Furnes A, Lie SA, Havelin LI, Engesaeter LB, Vollset SE. The economic impact of failures in total hip replacement surgery: 28,997 cases from the Norwegian arthroplasty register, 1987-1993. Acta Orthop Scand. 1996;67(2):115–21. https://doi.org/10.3109/17453679608994653.

    Article  CAS  PubMed  Google Scholar 

  141. Fusco F, Campbell H, Barker K. Rehabilitation after resurfacing hip arthroplasty: cost-utility analysis alongside a randomized controlled trial. Clin Rehabil. 2019;33(6):1003–14. https://doi.org/10.1177/0269215519827628. A full economic evaluation of an RCT comparing telerehabilitation to usual care after total knee arthroplasty that scored a perfect 100 on the Quality of Health Economics Studies (QHES) tool. The paper also completes both a cost-effectiveness and cost-utility analysis. The paper provides a great reference for researchers when designing studies and drafting manuscripts or for critical appraisal of studies.

  142. Fusco F, Turchetti G. Telerehabilitation after total knee replacement in Italy: cost-effectiveness and cost-utility analysis of a mixed telerehabilitation-standard rehabilitation programme compared with usual care. BMJ Open. 2016;6(5):e009964. https://doi.org/10.1136/bmjopen-2015-009964.

    Article  PubMed  PubMed Central  Google Scholar 

  143. Ghomrawi HM, Eggman AA, Pearle AD. Effect of age on cost-effectiveness of unicompartmental knee arthroplasty compared with total knee arthroplasty in the U.S. J Bone Joint Surg Am. 2015;97(5):396–402. https://doi.org/10.2106/jbjs.N.00169.

    Article  PubMed  PubMed Central  Google Scholar 

  144. Gililland JM, Anderson LA, Barney JK, Ross HL, Pelt CE, Peters CL. Barbed versus standard sutures for closure in total knee arthroplasty: a multicenter prospective randomized trial. J Arthroplast. 2014;29(9 Suppl):135–8. https://doi.org/10.1016/j.arth.2014.01.041.

    Article  Google Scholar 

  145. Gill J, Chase E, Rosenstein A. The use of tranexamic acid in revision total hip arthroplasty: a pilot study. Curr Orth Pract. 2009;20:152–6. https://doi.org/10.1097/BCO.0b013e318191ebc0.

    Article  Google Scholar 

  146. Gillette BP, Maradit Kremers H, Duncan CM, Smith HM, Trousdale RT, Pagnano MW, et al. Economic impact of tranexamic acid in healthy patients undergoing primary total hip and knee arthroplasty. J Arthroplast. 2013;28(8 Suppl):137–9. https://doi.org/10.1016/j.arth.2013.04.054.

    Article  Google Scholar 

  147. Gioe TJ, Sharma A, Tatman P, Mehle S. Do "premium" joint implants add value?: analysis of high cost joint implants in a community registry. Clin Orthop Relat Res. 2011;469(1):48–54. https://doi.org/10.1007/s11999-010-1436-z.

    Article  PubMed  Google Scholar 

  148. Gioe TJ, Sinner P, Mehle S, Ma W, Killeen KK. Excellent survival of all-polyethylene tibial components in a community joint registry. Clin Orthop Relat Res. 2007;464:88–92. https://doi.org/10.1097/BLO.0b013e31812f7879.

    Article  PubMed  Google Scholar 

  149. Glennie RA, Korczak A, Naudie DD, Bryant DM, Howard JL. MONOCRYL and DERMABOND vs Staples in Total hip arthroplasty performed through a lateral skin incision: a randomized controlled trial using a patient-Centered assessment tool. J Arthroplast. 2017;32(8):2431–5. https://doi.org/10.1016/j.arth.2017.02.042.

    Article  Google Scholar 

  150. Gonano C, Leitgeb U, Sitzwohl C, Ihra G, Weinstabl C, Kettner SC. Spinal versus general anesthesia for orthopedic surgery: anesthesia drug and supply costs. Anesth Analg. 2006;102(2):524–9. https://doi.org/10.1213/01.ane.0000194292.81614.c6.

    Article  PubMed  Google Scholar 

  151. Goodnough LT, Despotis GJ, Merkel K, Monk TG. A randomized trial comparing acute normovolemic hemodilution and preoperative autologous blood donation in total hip arthroplasty. Transfusion. 2000;40(9):1054–7. https://doi.org/10.1046/j.1537-2995.2000.40091054.x.

    Article  CAS  PubMed  Google Scholar 

  152. Gordois A, Posnett J, Borris L, Bossuyt P, Jonsson B, Levy E, et al. The cost-effectiveness of fondaparinux compared with enoxaparin as prophylaxis against thromboembolism following major orthopedic surgery. J Thromb Haemost. 2003;1(10):2167–74. https://doi.org/10.1046/j.1538-7836.2003.00396.x.

    Article  CAS  PubMed  Google Scholar 

  153. Gothesen O, Slover J, Havelin L, Askildsen JE, Malchau H, Furnes O. An economic model to evaluate cost-effectiveness of computer assisted knee replacement surgery in Norway. BMC Musculoskelet Disord. 2013;14:202. https://doi.org/10.1186/1471-2474-14-202.

    Article  PubMed  PubMed Central  Google Scholar 

  154. Gower A, Hussein AI, Briggs PJ, Dewar MS. Blood utilization in hip and knee arthroplasty: a cost-minimization study. J R Coll Surg Edinb. 1998;43(6):397–9.

    CAS  PubMed  Google Scholar 

  155. Graves N, Halton K, Lairson D. Economics and preventing hospital-acquired infection: broadening the perspective. Infect Control Hosp Epidemiol. 2007;28(2):178–84. https://doi.org/10.1086/510787.

    Article  PubMed  Google Scholar 

  156. Green WS, Toy P, Bozic KJ. Cost minimization analysis of preoperative erythropoietin vs autologous and allogeneic blood donation in total joint arthroplasty. J Arthroplast. 2010;25(1):93–6. https://doi.org/10.1016/j.arth.2008.10.005.

    Article  Google Scholar 

  157. Gustke KA, Gelbke MK. All-polyethylene Tibial component use for elderly, low-demand Total knee arthroplasty patients. J Arthroplast. 2017;32(8):2421–6. https://doi.org/10.1016/j.arth.2017.02.077.

    Article  Google Scholar 

  158. Gutowski CJ, Zmistowski BM, Clyde CT, Parvizi J. The economics of using prophylactic antibiotic-loaded bone cement in total knee replacement. Bone Joint J. 2014;96-b(1):65–9. https://doi.org/10.1302/0301-620x.96b1.31428.

    Article  CAS  PubMed  Google Scholar 

  159. Gutowski CJ, Zmistowski BM, Lonner JH, Purtill JJ, Parvizi J. Direct costs of aspirin versus warfarin for venous thromboembolism prophylaxis after Total knee or hip arthroplasty. J Arthroplast. 2015;30(9 Suppl):36–8. https://doi.org/10.1016/j.arth.2015.04.048.

    Article  Google Scholar 

  160. Haentjens P, De Groote K, Annemans L. Prolonged enoxaparin therapy to prevent venous thromboembolism after primary hip or knee replacement. A cost-utility analysis. Arch Orthop Trauma Surg. 2004;124(8):507–17. https://doi.org/10.1007/s00402-004-0720-3.

    Article  PubMed  Google Scholar 

  161. Halleberg Nyman M, Gustafsson M, Langius-Eklof A, Johansson JE, Norlin R, Hagberg L. Intermittent versus indwelling urinary catheterisation in hip surgery patients: a randomised controlled trial with cost-effectiveness analysis. Int J Nurs Stud. 2013;50(12):1589–98. https://doi.org/10.1016/j.ijnurstu.2013.05.007.

    Article  PubMed  Google Scholar 

  162. Hamidi V, Ringerike T, Hagen G, Reikvam A, Klemp M. New anticoagulants as thromboprophylaxis after total hip or knee replacement. Int J Technol Assess Health Care. 2013;29(3):234–43. https://doi.org/10.1017/s0266462313000251.

    Article  PubMed  Google Scholar 

  163. Hamilton DF, Clement ND, Burnett R, Patton JT, Moran M, Howie CR, et al. Do modern total knee replacements offer better value for money? A health economic analysis. Int Orthop. 2013;37(11):2147–52. https://doi.org/10.1007/s00264-013-1992-4.

    Article  PubMed  PubMed Central  Google Scholar 

  164. Hansen TB, Jacobsen F, Larsen K. Cost effective interprofessional training: an evaluation of a training unit in Denmark. J Interprof Care. 2009;23(3):234–41. https://doi.org/10.1080/13561820802602420.

    Article  PubMed  Google Scholar 

  165. Happe LE, Farrelly EM, Stanford RH, Sarnes MW. Cost and occurrence of thrombocytopenia in patients receiving venous thromboembolism prophylaxis following major orthopaedic surgeries. J Thromb Thrombolysis. 2008;26(2):125–31. https://doi.org/10.1007/s11239-007-0170-1.

    Article  PubMed  Google Scholar 

  166. Harper RA, Sucher MG, Giordani M, Nedopil AJ. Topically applied epsilon-aminocaproic acid reduces blood loss and length of hospital stay after total knee arthroplasty. Orthopedics. 2017;40(6):e1044–e9. https://doi.org/10.3928/01477447-20170925-07.

    Article  PubMed  Google Scholar 

  167. Hawker GA, Badley EM, Croxford R, Coyte PC, Glazier RH, Guan J, et al. A population-based nested case-control study of the costs of hip and knee replacement surgery. Med Care. 2009;47(7):732–41. https://doi.org/10.1097/MLR.0b013e3181934553.

    Article  PubMed  Google Scholar 

  168. Hawkins DW, Langley PC, Krueger KP. Pharmacoeconomic model of enoxaparin versus heparin for prevention of deep vein thrombosis after total hip replacement. Am J Health-Syst Pharm. 1997;54(10):1185–90. https://doi.org/10.1093/ajhp/54.10.1185.

    Article  CAS  PubMed  Google Scholar 

  169. Hawkins DW, Langley PC, Krueger KP. A pharmacoeconomic assessment of enoxaparin and warfarin as prophylaxis for deep vein thrombosis in patients undergoing knee replacement surgery. Clin Ther. 1998;20(1):182–95. https://doi.org/10.1016/s0149-2918(98)80045-3.

    Article  CAS  PubMed  Google Scholar 

  170. Healy WL, Iorio R, Ko J, Appleby D, Lemos DW. Impact of cost reduction programs on short-term patient outcome and hospital cost of total knee arthroplasty. J Bone Joint Surg Am. 2002;84(3):348–53. https://doi.org/10.2106/00004623-200203000-00003.

    Article  PubMed  Google Scholar 

  171. Hebert CK, Williams RE, Levy RS, Barrack RL. Cost of treating an infected total knee replacement. Clin Orthop Relat Res. 1996;331:140–5. https://doi.org/10.1097/00003086-199610000-00019.

    Article  Google Scholar 

  172. Heintzbergen S, Kulin NA, Ijzerman MJ, Steuten LM, Werle J, Khong H, et al. Cost-utility of metal-on-metal hip resurfacing compared to conventional total hip replacement in young active patients with osteoarthritis. Value Health. 2013;16(6):942–52. https://doi.org/10.1016/j.jval.2013.06.021.

    Article  PubMed  Google Scholar 

  173. Hejblum G, Atsou K, Dautzenberg B, Chouaid C. Cost-benefit analysis of a simulated institution-based preoperative smoking cessation intervention in patients undergoing total hip and knee arthroplasties in France. Chest. 2009;135(2):477–83. https://doi.org/10.1378/chest.08-0897.

    Article  PubMed  Google Scholar 

  174. Henson KS, Thomley JE, Lowrie LJ, Walker D. Comparison of selected outcomes associated with two postoperative analgesic approaches in patients undergoing total knee arthroplasty. AANA J. 2019;87(1):51–7.

    PubMed  Google Scholar 

  175. Herbold JA, Bonistall K, Walsh MB. Rehabilitation following total knee replacement, total hip replacement, and hip fracture: a case-controlled comparison. J Geriatr Phys Ther (2001). 2011;34(4):155–60. https://doi.org/10.1519/JPT.0b013e318216db81.

    Article  Google Scholar 

  176. Higashi H, Barendregt JJ. Cost-effectiveness of total hip and knee replacements for the Australian population with osteoarthritis: discrete-event simulation model. PLoS One. 2011;6(9):e25403. https://doi.org/10.1371/journal.pone.0025403.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  177. Ho DM, Huo MH. Are critical pathways and implant standardization programs effective in reducing costs in total knee replacement operations? J Am Coll Surg. 2007;205(1):97–100. https://doi.org/10.1016/j.jamcollsurg.2007.03.009.

    Article  PubMed  Google Scholar 

  178. Hodge WA. Prevention of deep vein thrombosis after total knee arthroplasty. Coumadin versus pneumatic calf compression. Clin Orthop Relat Res. 1991;271:101–5.

    Google Scholar 

  179. Honorato J, Gomez-Outes A, Navarro-Quilis A, Martinez-Gonzalez J, Rocha E, Planes A. Pharmacoeconomic analysis of bemiparin and enoxaparin as prophylaxis for venous thromboembolism in total knee replacement surgery. PharmacoEconomics. 2004;22(13):885–94. https://doi.org/10.2165/00019053-200422130-00006.

    Article  CAS  PubMed  Google Scholar 

  180. Hsieh PH, Huang KC, Lee PC, Lee MS. Two-stage revision of infected hip arthroplasty using an antibiotic-loaded spacer: retrospective comparison between short-term and prolonged antibiotic therapy. J Antimicrob Chemother. 2009;64(2):392–7. https://doi.org/10.1093/jac/dkp177.

    Article  CAS  PubMed  Google Scholar 

  181. Hsu AR, Gross CE, Bhatia S, Levine BR. Template-directed instrumentation in total knee arthroplasty: cost savings analysis. Orthopedics. 2012;35(11):e1596–600. https://doi.org/10.3928/01477447-20121023-15.

    Article  PubMed  Google Scholar 

  182. Huang SW, Chen PH, Chou YH. Effects of a preoperative simplified home rehabilitation education program on length of stay of total knee arthroplasty patients. Orthop Traumatol Surg Res. 2012;98(3):259–64. https://doi.org/10.1016/j.otsr.2011.12.004.

    Article  PubMed  Google Scholar 

  183. Huddleston JM, Long KH, Naessens JM, Vanness D, Larson D, Trousdale R, et al. Medical and surgical comanagement after elective hip and knee arthroplasty: a randomized, controlled trial. Ann Intern Med. 2004;141(1):28–38. https://doi.org/10.7326/0003-4819-141-1-200407060-00012.

    Article  PubMed  Google Scholar 

  184. Hunt GR, Crealey G, Murthy BV, Hall GM, Constantine P, O'Brien S, et al. The consequences of early discharge after hip arthroplasty for patient outcomes and health care costs: comparison of three centres with differing durations of stay. Clin Rehabil. 2009;23(12):1067–77. https://doi.org/10.1177/0269215509339000.

    Article  PubMed  Google Scholar 

  185. Hyland SJ, Deliberato DG, Fada RA, Romanelli MJ, Collins CL, Wasielewski RC. Liposomal bupivacaine versus standard periarticular injection in total knee arthroplasty with regional anesthesia: a prospective randomized controlled trial. J Arthroplast. 2019;34(3):488–94. https://doi.org/10.1016/j.arth.2018.11.026.

    Article  Google Scholar 

  186. Ilfeld BM, Mariano ER, Williams BA, Woodard JN, Macario A. Hospitalization costs of total knee arthroplasty with a continuous femoral nerve block provided only in the hospital versus on an ambulatory basis: a retrospective, case-control, cost-minimization analysis. Reg Anesth Pain Med. 2007;32(1):46–54. https://doi.org/10.1016/j.rapm.2006.10.010.

    Article  PubMed  PubMed Central  Google Scholar 

  187. Iorio R, Healy WL, Patch DA, Appleby D. The role of bladder catheterization in total knee arthroplasty. Clin Orthop Relat Res. 2000;380:80–4. https://doi.org/10.1097/00003086-200011000-00011.

    Article  Google Scholar 

  188. Iorio R, Whang W, Healy WL, Patch DA, Najibi S, Appleby D. The utility of bladder catheterization in total hip arthroplasty. Clin Orthop Relat Res. 2005;432:148–52. https://doi.org/10.1097/01.blo.0000149823.57513.00.

    Article  Google Scholar 

  189. Irisson E, Hemon Y, Pauly V, Parratte S, Argenson JN, Kerbaul F. Tranexamic acid reduces blood loss and financial cost in primary total hip and knee replacement surgery. Orthop Traumatol Surg Res. 2012;98(5):477–83. https://doi.org/10.1016/j.otsr.2012.05.002.

    Article  CAS  PubMed  Google Scholar 

  190. Jackson BR, Umlas J, AuBuchon JP. The cost-effectiveness of postoperative recovery of RBCs in preventing transfusion-associated virus transmission after joint arthroplasty. Transfusion. 2000;40(9):1063–6. https://doi.org/10.1046/j.1537-2995.2000.40091063.x.

    Article  CAS  PubMed  Google Scholar 

  191. Jacobson JJ, Schweitzer SO, Kowalski CJ. Chemoprophylaxis of prosthetic joint patients during dental treatment: a decision-utility analysis. Oral Surg Oral Med Oral Pathol. 1991;72(2):167–77. https://doi.org/10.1016/0030-4220(91)90159-a.

    Article  CAS  PubMed  Google Scholar 

  192. Jiang Y, Du H, Liu J, Zhou Y. Aspirin combined with mechanical measures to prevent venous thromboembolism after total knee arthroplasty: a randomized controlled trial. Chin Med J. 2014;127(12):2201–5.

    CAS  PubMed  Google Scholar 

  193. Johansson T, Pettersson LG, Lisander B. Tranexamic acid in total hip arthroplasty saves blood and money: a randomized, double-blind study in 100 patients. Acta Orthop. 2005;76(3):314–9.

    PubMed  Google Scholar 

  194. Johnson CB, Steele-Moses SK. The use of continuous femoral nerve blocks versus extended release epidural morphine: a study comparing outcomes in total knee arthroplasty procedures. Orthop Nurs. 2011;30(1):44–53. https://doi.org/10.1097/NOR.0b013e31820574b2.

    Article  PubMed  Google Scholar 

  195. Johnson JP, Kleiner J, Goodman AD, Gil JA, Daniels AH, Hayda RA. Treatment of femoral neck fractures in patients 45-64 years of age. Injury. 2019;50(3):708–12. https://doi.org/10.1016/j.injury.2018.11.020.

    Article  PubMed  Google Scholar 

  196. Jonas SC, Shah R, Mitra A, Deo SD. 5-year cost/benefit analysis of revision of failed unicompartmental knee replacements (UKRs); not "just" a primary total knee replacement (TKR). Knee. 2014;21(4):840–2. https://doi.org/10.1016/j.knee.2014.04.012.

    Article  PubMed  Google Scholar 

  197. Jones HW, Savage L, White C, Goddard R, Lumley H, Kashif F, et al. Postoperative autologous blood salvage drains--are they useful in primary uncemented hip and knee arthroplasty? A prospective study of 186 cases. Acta Orthop Belg. 2004;70(5):466–73.

    PubMed  Google Scholar 

  198. Jordan LR, Siegel JL, Olivo JL. Early flexion routine. An alternative method of continuous passive motion. Clin Orthop Relat Res. 1995;315:231–3.

    Google Scholar 

  199. Kallala RF, Vanhegan IS, Ibrahim MS, Sarmah S, Haddad FS. Financial analysis of revision knee surgery based on NHS tariffs and hospital costs: does it pay to provide a revision service? Bone Joint J. 2015;97-b(2):197–201. https://doi.org/10.1302/0301-620x.97b2.33707.

    Article  CAS  PubMed  Google Scholar 

  200. Kalore NV, Maheshwari A, Sharma A, Cheng E, Gioe TJ. Is there a preferred articulating spacer technique for infected knee arthroplasty? A preliminary study. Clin Orthop Relat Res. 2012;470(1):228–35. https://doi.org/10.1007/s11999-011-2037-1.

    Article  PubMed  Google Scholar 

  201. Kamath AF, Lee GC, Sheth NP, Nelson CL, Garino JP, Israelite CL. Prospective results of uncemented tantalum monoblock tibia in total knee arthroplasty: minimum 5-year follow-up in patients younger than 55 years. J Arthroplast. 2011;26(8):1390–5. https://doi.org/10.1016/j.arth.2011.06.030.

    Article  Google Scholar 

  202. Kapadia BH, McElroy MJ, Issa K, Johnson AJ, Bozic KJ, Mont MA. The economic impact of periprosthetic infections following total knee arthroplasty at a specialized tertiary-care center. J Arthroplast. 2014;29(5):929–32. https://doi.org/10.1016/j.arth.2013.09.017.

    Article  Google Scholar 

  203. Karuppiah SV, Banaszkiewicz PA, Ledingham WM. The mortality, morbidity and cost benefits of elective total knee arthroplasty in the nonagenarian population. Int Orthop. 2008;32(3):339–43. https://doi.org/10.1007/s00264-007-0324-y.

    Article  CAS  PubMed  Google Scholar 

  204. Kasch R, Merk S, Assmann G, Lahm A, Napp M, Merk H, et al. Comparative analysis of direct hospital care costs between aseptic and two-stage septic knee revision. PLoS One. 2017;12(1):e0169558. https://doi.org/10.1371/journal.pone.0169558.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  205. Kasch R, Merk S, Drescher W, Schulz AP, Kayser R, Skripitz R, et al. Marginal contribution of UKS- versus TKA in varus arthritis of the knee. Arch Orthop Trauma Surg. 2012;132(8):1165–72. https://doi.org/10.1007/s00402-012-1535-2.

    Article  PubMed  Google Scholar 

  206. Kathrins B, Kathrins R, Marsico R, Frank M, Stevenson-Marshall B, Orozco F, et al. Comparison of day rehabilitation to skilled nursing facility for the rehabilitation for total knee arthroplasty. Am J Phys Med Rehabil. 2013;92(1):61–7. https://doi.org/10.1097/PHM.0b013e3182643fd5.

    Article  PubMed  Google Scholar 

  207. Kauppila AM, Sintonen H, Aronen P, Ohtonen P, Kyllonen E, Arokoski JP. Economic evaluation of multidisciplinary rehabilitation after primary total knee arthroplasty based on a randomized controlled trial. Arthritis Care Res. 2011;63(3):335–41. https://doi.org/10.1002/acr.20398.

    Article  Google Scholar 

  208. Kim K, Elbuluk A, Yu S, Iorio R. Cost-effective peri-operative pain management: assuring a happy patient after total knee arthroplasty. Bone Joint J. 2018;100-b(1 Supple A):55–61. https://doi.org/10.1302/0301-620x.100b1.Bjj-2017-0549.R1.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  209. Klouche S, Sariali E, Mamoudy P. Total hip arthroplasty revision due to infection: a cost analysis approach. Orthop Traumatol Surg Res. 2010;96(2):124–32. https://doi.org/10.1016/j.rcot.2010.02.005.

    Article  CAS  PubMed  Google Scholar 

  210. Knight RM, Pellegrini VD, Jr. Bladder management after total joint arthroplasty. J Arthroplast 1996;11(8):882–8. doi:https://doi.org/10.1016/s0883-5403(96)80127-6.

  211. Koek MBG, van der Kooi TII, Stigter FCA, de Boer PT, de Gier B, Hopmans TEM, et al. Burden of surgical site infections in the Netherlands: cost analyses and disability-adjusted life years. J Hosp Infect. 2019;103(3):293–302. https://doi.org/10.1016/j.jhin.2019.07.010.

    Article  CAS  PubMed  Google Scholar 

  212. Konopka JF, Gomoll AH, Thornhill TS, Katz JN, Losina E. The cost-effectiveness of surgical treatment of medial unicompartmental knee osteoarthritis in younger patients: a computer model-based evaluation. J Bone Joint Surg Am. 2015;97(10):807–17. https://doi.org/10.2106/jbjs.N.00925.

    Article  PubMed  PubMed Central  Google Scholar 

  213. Koskinen E, Eskelinen A, Paavolainen P, Pulkkinen P, Remes V. Comparison of survival and cost-effectiveness between unicondylar arthroplasty and total knee arthroplasty in patients with primary osteoarthritis: a follow-up study of 50,493 knee replacements from the Finnish arthroplasty register. Acta Orthop. 2008;79(4):499–507. https://doi.org/10.1080/17453670710015490.

    Article  PubMed  Google Scholar 

  214. Kovacik MW, Singri P, Khanna S, Gradisar IA. Medical and financial aspects of same-day bilateral total knee arthroplasties. Biomed Sci Instrum. 1997;33:429–34.

    CAS  PubMed  Google Scholar 

  215. Kritikou G, Avgerinos KI, Koutserimpas C, Sourri F, Hatzigeorgiou D, Kottaridi C, et al. Effectiveness of a preventive bundle of measures for reducing surgical site infections in patients undergoing elective orthopedic procedures in a Hellenic air force hospital. Il Giornale di chirurgia. 2019;40(2):120–6.

    CAS  PubMed  Google Scholar 

  216. Krotenberg R, Adler U, Pomeranz B, Miller JD, Russell MW. Dalteparin vs. enoxaparin as prophylaxis for deep-vein thrombosis after total hip or knee arthroplasty: a retrospective analysis. Am J Phys Med Rehabil. 2001;80(12):889–95. https://doi.org/10.1097/00002060-200112000-00004.

    Article  CAS  PubMed  Google Scholar 

  217. Krummenauer F, Guenther KP, Kirschner S. Cost effectiveness of total knee arthroplasty from a health care providers’ perspective before and after introduction of an interdisciplinary clinical pathway‑is investment always improvement? BMC Health Serv Res. 2011;11:338. https://doi.org/10.1186/1472-6963-11-338.

    Article  PubMed  PubMed Central  Google Scholar 

  218. Kuznietsova V, Woodward RS. Estimating the learning curve of a novel medical device: bipolar sealer use in unilateral total knee arthroplasties. Value Health. 2018;21(3):283–94. https://doi.org/10.1016/j.jval.2017.03.002.

    Article  PubMed  Google Scholar 

  219. Lane GJ, Hozack WJ, Shah S, Rothman RH, Booth RE Jr, Eng K, et al. Simultaneous bilateral versus unilateral total knee arthroplasty. Outcomes analysis. Clin Orthop Relat Res. 1997;345:106–12.

    Google Scholar 

  220. Larsen K, Hansen TB, Thomsen PB, Christiansen T, Soballe K. Cost-effectiveness of accelerated perioperative care and rehabilitation after total hip and knee arthroplasty. J Bone Joint Surg Am. 2009;91(4):761–72. https://doi.org/10.2106/jbjs.G.01472.

    Article  PubMed  Google Scholar 

  221. Laupacis A, Bourne R, Rorabeck C, Feeny D, Wong C, Tugwell P, et al. Costs of elective total hip arthroplasty during the first year. Cemented versus noncemented. J Arthroplast. 1994;9(5):481–7. https://doi.org/10.1016/0883-5403(94)90093-0.

    Article  CAS  Google Scholar 

  222. Lavernia CJ. Cost-effectiveness of early surgical intervention in silent osteolysis. J Arthroplast. 1998;13(3):277–9. https://doi.org/10.1016/s0883-5403(98)90172-3.

    Article  CAS  Google Scholar 

  223. Lavernia CJ, Alcerro JC. Quality of life and cost-effectiveness 1 year after total hip arthroplasty. J Arthroplast. 2011;26(5):705–9. https://doi.org/10.1016/j.arth.2010.07.026.

    Article  Google Scholar 

  224. Lavernia CJ, D'Apuzzo MR, Hernandez VH, Lee DJ, Rossi MD. Postdischarge costs in arthroplasty surgery. J Arthroplast. 2006;21(6 Suppl 2):144–50. https://doi.org/10.1016/j.arth.2006.05.003.

    Article  Google Scholar 

  225. Lavernia CJ, Guzman JF, Gachupin-Garcia A. Cost effectiveness and quality of life in knee arthroplasty. Clin Orthop Relat Res. 1997;345:134–9.

    Google Scholar 

  226. Lavernia CJ, Sierra RJ, Hernandez RA. The cost of teaching total knee arthroplasty surgery to orthopaedic surgery residents. Clin Orthop Relat Res. 2000;380:99–107. https://doi.org/10.1097/00003086-200011000-00014.

    Article  Google Scholar 

  227. Lawrie CM, Schwabe M, Pierce A, Nunley RM, Barrack RL. The cost of implanting a cemented versus cementless total knee arthroplasty. Bone Joint J. 2019;101-b(7_Supple_C):61–3. https://doi.org/10.1302/0301-620x.101b7.Bjj-2018-1470.R1.

    Article  CAS  PubMed  Google Scholar 

  228. Levin LA, Bergqvist D. Cost effectiveness of desirudin compared with a low molecular weight heparin in the prevention of deep vein thrombosis after total hip replacement surgery. PharmacoEconomics. 2001;19(5 Pt 2):589–97. https://doi.org/10.2165/00019053-200119050-00012.

    Article  CAS  PubMed  Google Scholar 

  229. Levin LA, Horst M, Bergqvist D. Economic evaluation of desirudin vs heparin in deep vein thrombosis prevention after hip replacement surgery. PharmacoEconomics. 1998;13(1 Pt 2):111–8. https://doi.org/10.2165/00019053-199813010-00010.

    Article  CAS  PubMed  Google Scholar 

  230. Li CS, Seeger T, Auhuber TC, Bhandari M. Cost-effectiveness and economic impact of the KineSpring (R) knee implant system in the treatment for knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2013;21(11):2629–37. https://doi.org/10.1007/s00167-013-2427-x.

    Article  PubMed  Google Scholar 

  231. Lin PC, Hung SH, Wu HF, Hsu HC, Chu CY, Su SJ. The effects of a care map for total knee replacement patients. J Clin Nurs. 2011;20(21–22):3119–27. https://doi.org/10.1111/j.1365-2702.2011.03804.x.

    Article  PubMed  Google Scholar 

  232. Lorenze M, Huo MH, Zatorski LE, Keggi KJ. A comparison of the cost effectiveness of one-stage versus two-stage bilateral total hip replacement. Orthopedics. 1998;21(12):1249–52.

    CAS  PubMed  Google Scholar 

  233. Losina E, Daigle ME, Suter LG, Hunter DJ, Solomon DH, Walensky RP, et al. Disease-modifying drugs for knee osteoarthritis: can they be cost-effective? Osteoarthr Cartil. 2013;21(5):655–67. https://doi.org/10.1016/j.joca.2013.01.016.

    Article  CAS  Google Scholar 

  234. Losina E, Walensky RP, Kessler CL, Emrani PS, Reichmann WM, Wright EA, et al. Cost-effectiveness of total knee arthroplasty in the United States: patient risk and hospital volume. Arch Intern Med. 2009;169(12):1113–21; discussion 21-2. https://doi.org/10.1001/archinternmed.2009.136.

    Article  PubMed  PubMed Central  Google Scholar 

  235. Lovald ST, Ong KL, Lau EC, Schmier JK, Bozic KJ, Kurtz SM. Mortality, cost, and health outcomes of total knee arthroplasty in Medicare patients. J Arthroplast. 2013;28(3):449–54. https://doi.org/10.1016/j.arth.2012.06.036.

    Article  Google Scholar 

  236. Lovald ST, Ong KL, Lau EC, Schmier JK, Bozic KJ, Kurtz SM. Mortality, cost, and downstream disease of total hip arthroplasty patients in the medicare population. J Arthroplast. 2014;29(1):242–6. https://doi.org/10.1016/j.arth.2013.04.031.

    Article  Google Scholar 

  237. Lovald ST, Ong KL, Malkani AL, Lau EC, Schmier JK, Kurtz SM, et al. Complications, mortality, and costs for outpatient and short-stay total knee arthroplasty patients in comparison to standard-stay patients. J Arthroplast. 2014;29(3):510–5. https://doi.org/10.1016/j.arth.2013.07.020.

    Article  Google Scholar 

  238. Lozano M, Basora M, Peidro L, Merino I, Segur JM, Pereira A, et al. Effectiveness and safety of tranexamic acid administration during total knee arthroplasty. Vox Sang. 2008;95(1):39–44. https://doi.org/10.1111/j.1423-0410.2008.01045.x.

    Article  CAS  PubMed  Google Scholar 

  239. Lundkvist J, Bergqvist D, Jonsson B. Cost-effectiveness of fondaparinux vs. enoxaparin as venous thromboembolism prophylaxis in Sweden. Eur J Health Econ. 2003;4(4):254–62. https://doi.org/10.1007/s10198-003-0175-4.

    Article  PubMed  Google Scholar 

  240. Luo ZY, Wang HY, Wang D, Zhou K, Pei FX, Zhou ZK. Oral vs intravenous vs topical tranexamic acid in primary hip arthroplasty: a prospective, randomized, double-blind, controlled study. J Arthroplast. 2018;33(3):786–93. https://doi.org/10.1016/j.arth.2017.09.062.

    Article  Google Scholar 

  241. Mac HL, Reynolds MA, Treston-Aurand J, Henke JA. Comparison of autoreinfusion and standard drainage systems in total joint arthroplasty patients. Orthop Nurs. 1993;12(3):19–25. https://doi.org/10.1097/00006416-199305000-00005.

    Article  CAS  PubMed  Google Scholar 

  242. Macario A, Horne M, Goodman S, Vitez T, Dexter F, Heinen R, et al. The effect of a perioperative clinical pathway for knee replacement surgery on hospital costs. Anesth Analg. 1998;86(5):978–84. https://doi.org/10.1097/00000539-199805000-00012.

    Article  CAS  PubMed  Google Scholar 

  243. Macario A, Schilling P, Rubio R, Goodman S. Economics of one-stage versus two-stage bilateral total knee arthroplasties. Clin Orthop Relat Res. 2003;414:149–56. https://doi.org/10.1097/01.blo.0000079265.91782.ca.

    Article  Google Scholar 

  244. Mah ET, Davis R, Seshadri P, Nyman TL, Seshadri R. The role of autologous blood transfusion in joint replacement surgery. Anaesth Intensive Care. 1995;23(4):472–7. https://doi.org/10.1177/0310057x9502300411.

    Article  CAS  PubMed  Google Scholar 

  245. Mahmoudi M, Sobieraj DM. The cost-effectiveness of oral direct factor Xa inhibitors compared with low-molecular-weight heparin for the prevention of venous thromboembolism prophylaxis in total hip or knee replacement surgery. Pharmacotherapy. 2013;33(12):1333–40. https://doi.org/10.1002/phar.1269.

    Article  PubMed  Google Scholar 

  246. Mahomed NN, Davis AM, Hawker G, Badley E, Davey JR, Syed KA, et al. Inpatient compared with home-based rehabilitation following primary unilateral total hip or knee replacement: a randomized controlled trial. J Bone Joint Surg Am. 2008;90(8):1673–80. https://doi.org/10.2106/jbjs.G.01108.

    Article  PubMed  Google Scholar 

  247. Maiese BA, Pham AT, Shah MV, Eaddy MT, Lunacsek OE, Wan GJ. Hospitalization costs for patients undergoing orthopedic surgery treated with intravenous acetaminophen (IV-APAP) plus other IV analgesics or IV opioid monotherapy for postoperative pain. Adv Ther. 2017;34(2):421–35. https://doi.org/10.1007/s12325-016-0449-8.

    Article  PubMed  Google Scholar 

  248. Malhotra R, Jain V, Kumar V, Gautam D. Evaluation of running knotless barbed suture for capsular closure in primary total knee arthroplasty for osteoarthritis-a prospective randomized study. Int Orthop. 2017;41(10):2061–6. https://doi.org/10.1007/s00264-017-3529-8.

    Article  PubMed  Google Scholar 

  249. Mall NA, Nunley RM, Smith KE, Maloney WJ, Clohisy JC, Barrack RL. The fate of grafting acetabular defects during revision total hip arthroplasty. Clin Orthop Relat Res. 2010;468(12):3286–94. https://doi.org/10.1007/s11999-010-1427-0.

    Article  PubMed  PubMed Central  Google Scholar 

  250. Manoli A 3rd, Markel JF, Pizzimenti NM, Markel DC. Early results of a modern uncemented total knee arthroplasty system. Orthopedics. 2019;42(6):355–60. https://doi.org/10.3928/01477447-20190906-04.

    Article  PubMed  Google Scholar 

  251. Marchetti M, Liberato NL, Ruperto N, Barosi G. Long-term cost-effectiveness of low molecular weight heparin versus unfractionated heparin for the prophylaxis of venous thromboembolism in elective hip replacement. Haematologica. 1999;84(8):730–7.

    CAS  PubMed  Google Scholar 

  252. Marinelli M, Soccetti A, Panfoli N, de Palma L. Cost-effectiveness of cemented versus cementless total hip arthroplasty. A Markov decision analysis based on implant cost. J Orthop Traumatol. 2008;9(1):23–8. https://doi.org/10.1007/s10195-008-0100-9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  253. Marques EM, Blom AW, Lenguerrand E, Wylde V, Noble SM. Local anaesthetic wound infiltration in addition to standard anaesthetic regimen in total hip and knee replacement: long-term cost-effectiveness analyses alongside the APEX randomised controlled trials. BMC Med. 2015;13:151. https://doi.org/10.1186/s12916-015-0389-1.

    Article  PubMed  PubMed Central  Google Scholar 

  254. Marsh J, Hoch JS, Bryant D, MacDonald SJ, Naudie D, McCalden R, et al. Economic evaluation of web-based compared with in-person follow-up after total joint arthroplasty. J Bone Joint Surg Am. 2014;96(22):1910–6. https://doi.org/10.2106/jbjs.M.01558.

    Article  PubMed  Google Scholar 

  255. Marsh J, Somerville L, Howard JL, Lanting BA. Significant cost savings and similar patient outcomes associated with early discharge following total knee arthroplasty. Can J Surg. 2019;62(1):20–4. https://doi.org/10.1503/cjs.002118.

    Article  PubMed  Google Scholar 

  256. Marsh JD, Bryant DM, MacDonald SJ, Naudie DD, McCalden RW, Howard JL, et al. Feasibility, effectiveness and costs associated with a web-based follow-up assessment following total joint arthroplasty. J Arthroplast. 2014;29(9):1723–8. https://doi.org/10.1016/j.arth.2014.04.003.

    Article  Google Scholar 

  257. Martin GR, Marsh JD, Vasarhelyi EM, Howard JL, Lanting BA. A cost analysis of single-stage bilateral versus two-stage direct anterior total hip arthroplasty. Hip Int. 2016;26(1):15–9. https://doi.org/10.5301/hipint.5000292.

    Article  PubMed  Google Scholar 

  258. Martin R, Clayson PE, Troussel S, Fraser BP, Docquier PL. Anterolateral minimally invasive total hip arthroplasty: a prospective randomized controlled study with a follow-up of 1 year. J Arthroplast. 2011;26(8):1362–72. https://doi.org/10.1016/j.arth.2010.11.016.

    Article  Google Scholar 

  259. Massin P, Scemama C, Jeanrot C, Boyer P. Does fibrin sealant use in total knee replacement reduce transfusion rates? A non-randomised comparative study. Orthop Traumatol Surg Res. 2012;98(2):180–5. https://doi.org/10.1016/j.otsr.2011.10.012.

    Article  CAS  PubMed  Google Scholar 

  260. Mather RC 3rd, Hug KT, Orlando LA, Watters TS, Koenig L, Nunley RM, et al. Economic evaluation of access to musculoskeletal care: the case of waiting for total knee arthroplasty. BMC Musculoskelet Disord. 2014;15:22. https://doi.org/10.1186/1471-2474-15-22.

    Article  PubMed  PubMed Central  Google Scholar 

  261. McBryde CW, Dehne K, Pearson AM, Treacy RB, Pynsent PB. One- or two-stage bilateral metal-on-metal hip resurfacing arthroplasty. J Bone Joint Surg Br Vol. 2007;89(9):1144–8. https://doi.org/10.1302/0301-620x.89b9.19107.

    Article  CAS  Google Scholar 

  262. McCarron JA, Baumbusch C, Michelson JD, Manner PA. Economic evaluation of perioperative admissions for direct lateral versus two-incision minimally invasive total hip arthroplasty. Semin Arthroplast. 2008;19(2):180–5. https://doi.org/10.1053/j.sart.2008.02.004.

    Article  Google Scholar 

  263. McCullagh L, Tilson L, Walsh C, Barry M. A cost-effectiveness model comparing rivaroxaban and dabigatran etexilate with enoxaparin sodium as thromboprophylaxis after total hip and total knee replacement in the irish healthcare setting. PharmacoEconomics. 2009;27(10):829–46. https://doi.org/10.2165/11313800-000000000-00000.

    Article  PubMed  Google Scholar 

  264. McCullagh L, Walsh C, Barry M. Value-of-information analysis to reduce decision uncertainty associated with the choice of thromboprophylaxis after total hip replacement in the Irish healthcare setting. PharmacoEconomics. 2012;30(10):941–59. https://doi.org/10.2165/11591510-000000000-00000.

    Article  PubMed  Google Scholar 

  265. McDonald H, Diamantopoulos A, Wells P, Lees M, Folkerts K, Forster F, et al. Cost-effectiveness of rivaroxaban in the prevention of venous thromboembolism: a Canadian analysis using the Ontario Ministry of Health perspective. J Med Econ. 2012;15(5):817–28. https://doi.org/10.3111/13696998.2012.684116.

    Article  PubMed  Google Scholar 

  266. McGregor AH, Rylands H, Owen A, Dore CJ, Hughes SP. Does preoperative hip rehabilitation advice improve recovery and patient satisfaction? J Arthroplast. 2004;19(4):464–8. https://doi.org/10.1016/j.arth.2003.12.074.

    Article  Google Scholar 

  267. McInnes J, Larson MG, Daltroy LH, Brown T, Fossel AH, Eaton HM, et al. A controlled evaluation of continuous passive motion in patients undergoing total knee arthroplasty. JAMA. 1992;268(11):1423–8. https://doi.org/10.1001/jama.268.11.1423.

    Article  CAS  PubMed  Google Scholar 

  268. McKenzie L, Vale L, Stearns S, McCormack K. Metal on metal hip resurfacing arthroplasty. An economic analysis. Eur J Health Econ. 2003;4(2):122–9. https://doi.org/10.1007/s10198-002-0158-x.

    Article  CAS  PubMed  Google Scholar 

  269. McLawhorn AS, Carroll KM, Blevins JL, DeNegre ST, Mayman DJ, Jerabek SA. Template-directed instrumentation reduces cost and improves efficiency for total knee arthroplasty: an economic decision analysis and pilot study. J Arthroplast. 2015;30(10):1699–704. https://doi.org/10.1016/j.arth.2015.04.043.

    Article  Google Scholar 

  270. Memtsoudis SG, Sun X, Chiu YL, Stundner O, Liu SS, Banerjee S, et al. Perioperative comparative effectiveness of anesthetic technique in orthopedic patients. Anesthesiology. 2013;118(5):1046–58. https://doi.org/10.1097/ALN.0b013e318286061d.

    Article  PubMed  Google Scholar 

  271. Menzin J, Colditz GA, Regan MM, Richner RE, Oster G. Cost-effectiveness of enoxaparin vs low-dose warfarin in the prevention of deep-vein thrombosis after total hip replacement surgery. Arch Intern Med. 1995;155(7):757–64.

    CAS  PubMed  Google Scholar 

  272. Merollini KM, Crawford RW, Whitehouse SL, Graves N. Surgical site infection prevention following total hip arthroplasty in Australia: a cost-effectiveness analysis. Am J Infect Control. 2013;41(9):803–9. https://doi.org/10.1016/j.ajic.2012.11.015.

    Article  PubMed  Google Scholar 

  273. Mielke LL, Entholzner EK, Kling M, Breinbauer BE, Burgkart R, Hargasser SR, et al. Preoperative acute hypervolemic hemodilution with hydroxyethylstarch: an alternative to acute normovolemic hemodilution? Anesth Analg. 1997;84(1):26–30. https://doi.org/10.1097/00000539-199701000-00005.

    Article  CAS  PubMed  Google Scholar 

  274. Migliaccio-Walle K, Rublee D, Simon TA. Anticoagulation prophylaxis in orthopedic surgery: an efficiency frontier approach. Postgrad Med. 2012;124(1):41–9. https://doi.org/10.3810/pgm.2012.01.2516.

    Article  PubMed  Google Scholar 

  275. Mitchell C, Walker J, Walters S, Morgan AB, Binns T, Mathers N. Costs and effectiveness of pre- and post-operative home physiotherapy for total knee replacement: randomized controlled trial. J Eval Clin Pract. 2005;11(3):283–92. https://doi.org/10.1111/j.1365-2753.2005.00535.x.

    Article  PubMed  Google Scholar 

  276. Monreal M, Folkerts K, Diamantopoulos A, Imberti D, Brosa M. Cost-effectiveness impact of rivaroxaban versus new and existing prophylaxis for the prevention of venous thromboembolism after total hip or knee replacement surgery in France, Italy and Spain. Thromb Haemost. 2013;110(5):987–94. https://doi.org/10.1160/th12-12-0919.

    Article  CAS  PubMed  Google Scholar 

  277. Moonot P, D'Mello O, Tzinga N, Sisak K, Fiddian NJ, Harvey AH. Impact of change of knee prosthesis on early clinical outcomes in a large volume arthroplasty centre. Ann R Coll Surg Engl. 2013;95(8):573–6. https://doi.org/10.1308/003588413x13629960046796.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  278. Mortazavi SMJ, Haghpanah B, Ebrahiminasab MM, Baghdadi T, Hantooshzadeh R, Toogeh G. Simultaneous bilateral total knee arthroplasty in patients with haemophilia: a safe and cost-effective procedure? Haemophilia. 2016;22(2):303–7. https://doi.org/10.1111/hae.12832.

    Article  CAS  PubMed  Google Scholar 

  279. Moskal JT, Harris RN, Capps SG. Transfusion cost savings with tranexamic acid in primary total knee arthroplasty from 2009 to 2012. J Arthroplast. 2015;30(3):365–8. https://doi.org/10.1016/j.arth.2014.10.008.

    Article  Google Scholar 

  280. Mostafavi Tabatabaee R, Rasouli MR, Maltenfort MG, Parvizi J. Cost-effective prophylaxis against venous thromboembolism after total joint arthroplasty: warfarin versus aspirin. J Arthroplast. 2015;30(2):159–64. https://doi.org/10.1016/j.arth.2014.08.018.

    Article  Google Scholar 

  281. Mota RE. Cost-effectiveness analysis of early versus late total hip replacement in Italy. Value Health. 2013;16(2):267–79. https://doi.org/10.1016/j.jval.2012.10.020.

    Article  PubMed  Google Scholar 

  282. Moulton LS, Evans PA, Starks I, Smith T. Pre-operative education prior to elective hip arthroplasty surgery improves postoperative outcome. Int Orthop. 2015;39(8):1483–6. https://doi.org/10.1007/s00264-015-2754-2.

    Article  PubMed  Google Scholar 

  283. Munin MC, Rudy TE, Glynn NW, Crossett LS, Rubash HE. Early inpatient rehabilitation after elective hip and knee arthroplasty. JAMA. 1998;279(11):847–52. https://doi.org/10.1001/jama.279.11.847.

    Article  CAS  PubMed  Google Scholar 

  284. Munoz M, Ariza D, Campos A, Martin-Montanez E, Pavia J. The cost of post-operative shed blood salvage after total knee arthroplasty: an analysis of 1,093 consecutive procedures. Blood Transfus. 2013;11(2):260–71. https://doi.org/10.2450/2012.0139-12.

    Article  PubMed  PubMed Central  Google Scholar 

  285. Murray DW, MacLennan GS, Breeman S, Dakin HA, Johnston L, Campbell MK, et al. A randomised controlled trial of the clinical effectiveness and cost-effectiveness of different knee prostheses: the Knee Arthroplasty Trial (KAT). Health Technol Assess (Winchester, England). 2014;18(19):1–235, vii-viii. https://doi.org/10.3310/hta18190.

    Article  Google Scholar 

  286. Namin AT, Jalali MS, Vahdat V, Bedair HS, O'Connor MI, Kamarthi S, et al. Adoption of new medical technologies: the case of customized individually made knee implants. Value Health. 2019;22(4):423–30. https://doi.org/10.1016/j.jval.2019.01.008.

    Article  PubMed  Google Scholar 

  287. Naylor JM, Hart A, Mittal R, Harris I, Xuan W. The value of inpatient rehabilitation after uncomplicated knee arthroplasty: a propensity score analysis. Med J Aust. 2017;207(6):250–5. https://doi.org/10.5694/mja16.01362.

    Article  PubMed  Google Scholar 

  288. Negrin MA, Nam J, Briggs AH. Bayesian solutions for handling uncertainty in survival extrapolation. Medical decision making. Int J Soc Med Decis Mak. 2017;37(4):367–76. https://doi.org/10.1177/0272989x16650669.

    Article  Google Scholar 

  289. Nerurkar J, Wade WE, Martin BC. Cost/death averted with venous thromboembolism prophylaxis in patients undergoing total knee replacement or knee arthroplasty. Pharmacotherapy. 2002;22(8):990–1000. https://doi.org/10.1592/phco.22.12.990.33609.

    Article  PubMed  Google Scholar 

  290. Nherera LM, Trueman P, Karlakki SL. Cost-effectiveness analysis of single-use negative pressure wound therapy dressings (sNPWT) to reduce surgical site complications (SSC) in routine primary hip and knee replacements. Wound Repair Regen. 2017;25(3):474–82. https://doi.org/10.1111/wrr.12530.

    Article  PubMed  Google Scholar 

  291. Nichols CI, Vose JG. Comparative risk of transfusion and incremental total hospitalization cost for primary unilateral, bilateral, and revision total knee arthroplasty procedures. J Arthroplast. 2016;31(3):583–9.e1. https://doi.org/10.1016/j.arth.2015.10.013.

    Article  Google Scholar 

  292. Nodzo SR, Boyle KK, Spiro S, Nocon AA, Miller AO, Westrich GH. Success rates, characteristics, and costs of articulating antibiotic spacers for total knee periprosthetic joint infection. Knee. 2017;24(5):1175–81. https://doi.org/10.1016/j.knee.2017.05.016.

    Article  PubMed  Google Scholar 

  293. Novak EJ, Silverstein MD, Bozic KJ. The cost-effectiveness of computer-assisted navigation in total knee arthroplasty. J Bone Joint Surg Am. 2007;89(11):2389–97. https://doi.org/10.2106/jbjs.F.01109.

    Article  PubMed  Google Scholar 

  294. O’Brien BJ, Anderson DR, Goeree R. Cost-effectiveness of enoxaparin versus warfarin prophylaxis against deep-vein thrombosis after total hip replacement. Can Med Assoc J. 1994;150(7):1083–90.

    Google Scholar 

  295. Odum SM, Troyer JL, Kelly MP, Dedini RD, Bozic KJ. A cost-utility analysis comparing the cost-effectiveness of simultaneous and staged bilateral total knee arthroplasty. J Bone Joint Surg Am. 2013;95(16):1441–9. https://doi.org/10.2106/jbjs.L.00373.

    Article  PubMed  Google Scholar 

  296. Osnes-Ringen H, Kvamme MK, Kristiansen IS, Thingstad M, Henriksen JE, Kvien TK, et al. Cost-effectiveness analyses of elective orthopaedic surgical procedures in patients with inflammatory arthropathies. Scand J Rheumatol. 2011;40(2):108–15. https://doi.org/10.3109/03009742.2010.503661.

    Article  CAS  PubMed  Google Scholar 

  297. Paiement GD, Wessinger SJ, Harris WH. Cost-effectiveness of prophylaxis in total hip replacement. Am J Surg. 1991;161(4):519–24. https://doi.org/10.1016/0002-9610(91)91124-2.

    Article  CAS  PubMed  Google Scholar 

  298. Panchmatia JR, Chegini S, Lobban C, Shah G, Stapleton C, Smallman JM, et al. The routine use of tranexamic acid in hip and knee replacements. Bull NYU Hosp Joint Dis. 2012;70(4):246–9.

    Google Scholar 

  299. Parsons C, Batson R, Reighard S, Tanner S, Snider B, Pace TB. Clinical outcomes assessment of three similar hip arthroplasty bearing surfaces. Orthop Rev. 2014;6(2):5334. https://doi.org/10.4081/or.2014.5334.

    Article  Google Scholar 

  300. Peersman G, Jak W, Vandenlangenbergh T, Jans C, Cartier P, Fennema P. Cost-effectiveness of unicondylar versus total knee arthroplasty: a Markov model analysis. Knee. 2014;21(Suppl 1):S37–42. https://doi.org/10.1016/s0968-0160(14)50008-7.

    Article  PubMed  Google Scholar 

  301. Pennington M, Grieve R, Sekhon JS, Gregg P, Black N, van der Meulen JH. Cemented, cementless, and hybrid prostheses for total hip replacement: cost effectiveness analysis. BMJ (Clin Res ed). 2013;346:f1026. https://doi.org/10.1136/bmj.f1026.

    Article  Google Scholar 

  302. Pennington MW, Grieve R, van der Meulen JH. Lifetime cost effectiveness of different brands of prosthesis used for total hip arthroplasty: a study using the NJR dataset. Bone Joint J. 2015;97-b(6):762–70. https://doi.org/10.1302/0301-620x.97b6.34806.

    Article  CAS  PubMed  Google Scholar 

  303. Petis SM, Howard JL, Lanting BA, Marsh JD, Vasarhelyi EM. In-hospital cost analysis of total hip arthroplasty: does surgical approach matter? J Arthroplast. 2016;31(1):53–8. https://doi.org/10.1016/j.arth.2015.08.034.

    Article  Google Scholar 

  304. Pitimana-aree S, Visalyaputra S, Komoltri C, Muangman S, Tiviraj S, Puangchan S, et al. An economic evaluation of bupivacaine plus fentanyl versus ropivacaine alone for patient-controlled epidural analgesia after total-knee replacement procedure: a double-blinded randomized study. Reg Anesth Pain Med. 2005;30(5):446–51. https://doi.org/10.1016/j.rapm.2005.05.010.

    Article  CAS  PubMed  Google Scholar 

  305. Polly DW Jr, Glassman SD, Schwender JD, Shaffrey CI, Branch C, Burkus JK, et al. SF-36 PCS benefit-cost ratio of lumbar fusion comparison to other surgical interventions: a thought experiment. Spine. 2007;32(11 Suppl):S20–6. https://doi.org/10.1097/BRS.0b013e318053d4e5.

    Article  PubMed  Google Scholar 

  306. Ponnusamy KE, Naseer Z, El Dafrawy MH, Okafor L, Alexander C, Sterling RS, et al. Post-discharge care duration, charges, and outcomes among medicare patients after primary total hip and knee arthroplasty. J Bone Joint Surg Am. 2017;99(11):e55. https://doi.org/10.2106/jbjs.16.00166.

    Article  PubMed  Google Scholar 

  307. Ponnusamy KE, Vasarhelyi EM, Somerville L, McCalden RW, Marsh JD. Cost-effectiveness of total knee arthroplasty vs nonoperative management in normal, overweight, obese, severely obese, morbidly obese, and super-obese patients: a Markov model. J Arthroplast. 2018;33(7s):S32–s8. https://doi.org/10.1016/j.arth.2018.02.031.

    Article  Google Scholar 

  308. Postma MJ, Kappelhoff BS, van Hulst M, Brouwers JR. Economic evaluation of dabigatran etexilate for the primary prevention of venous tromboembolic events following major orthopedic surgery in the Netherlands. J Med Econ. 2012;15(5):878–86. https://doi.org/10.3111/13696998.2012.691144.

    Article  PubMed  Google Scholar 

  309. Pua YH, Ong PH. Association of early ambulation with length of stay and costs in total knee arthroplasty: retrospective cohort study. Am J Phys Med Rehabil. 2014;93(11):962–70. https://doi.org/10.1097/phm.0000000000000116.

    Article  PubMed  Google Scholar 

  310. Pulikottil-Jacob R, Connock M, Kandala NB, Mistry H, Grove A, Freeman K, et al. Cost effectiveness of total hip arthroplasty in osteoarthritis: comparison of devices with differing bearing surfaces and modes of fixation. Bone Joint J. 2015;97-b(4):449–57. https://doi.org/10.1302/0301-620x.97b4.34242.

    Article  CAS  PubMed  Google Scholar 

  311. Rajesparan K, Biant LC, Ahmad M, Field RE. The effect of an intravenous bolus of tranexamic acid on blood loss in total hip replacement. J Bone Joint Surg Br Vol. 2009;91(6):776–83. https://doi.org/10.1302/0301-620x.91b6.22393.

    Article  CAS  Google Scholar 

  312. Rao VK, Dyga R, Bartels C, Waters JH. A cost study of postoperative cell salvage in the setting of elective primary hip and knee arthroplasty. Transfusion. 2012;52(8):1750–60. https://doi.org/10.1111/j.1537-2995.2011.03531.x.

    Article  PubMed  PubMed Central  Google Scholar 

  313. Raphael IJ, McKenzie JC, Zmistowski B, Brown DB, Parvizi J, Austin MS. Pulmonary embolism after total joint arthroplasty: cost and effectiveness of four treatment modalities. J Arthroplast. 2014;29(5):933–7. https://doi.org/10.1016/j.arth.2013.09.033.

    Article  Google Scholar 

  314. Rasanen P, Paavolainen P, Sintonen H, Koivisto AM, Blom M, Ryynanen OP, et al. Effectiveness of hip or knee replacement surgery in terms of quality-adjusted life years and costs. Acta Orthop. 2007;78(1):108–15. https://doi.org/10.1080/17453670610013501.

    Article  PubMed  Google Scholar 

  315. Rees JE, Jeavons R, Dixon JH. An economic justification for autologous blood re-infusion in primary total knee replacement surgery. Ann R Coll Surg Engl. 2005;87(2):102–5. https://doi.org/10.1308/1478708051568.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  316. Reeves RA, Schairer WW, Jevsevar DS. Costs and risk factors for hospital readmission after periprosthetic knee fractures in the United States. J Arthroplast. 2018;33(2):324–30.e1. https://doi.org/10.1016/j.arth.2017.09.024.

    Article  Google Scholar 

  317. Reilly KA, Beard DJ, Barker KL, Dodd CA, Price AJ, Murray DW. Efficacy of an accelerated recovery protocol for Oxford unicompartmental knee arthroplasty--a randomised controlled trial. Knee. 2005;12(5):351–7. https://doi.org/10.1016/j.knee.2005.01.002.

    Article  CAS  PubMed  Google Scholar 

  318. Reuben JD, Meyers SJ, Cox DD, Elliott M, Watson M, Shim SD. Cost comparison between bilateral simultaneous, staged, and unilateral total joint arthroplasty. J Arthroplast. 1998;13(2):172–9. https://doi.org/10.1016/s0883-5403(98)90095-x.

    Article  CAS  Google Scholar 

  319. Revankar N, Patterson J, Kadambi A, Raymond V, El-Hadi W. A Canadian study of the cost-effectiveness of apixaban compared with enoxaparin for post-surgical venous thromboembolism prevention. Postgrad Med. 2013;125(4):141–53. https://doi.org/10.3810/pgm.2013.07.2686.

    Article  PubMed  Google Scholar 

  320. Ritter MA, Lutgring JD, Davis KE, Berend ME, Meding JB. A clinical, radiographic, and cost comparison of cerclage techniques: wires vs cables. J Arthroplast. 2006;21(7):1064–7. https://doi.org/10.1016/j.arth.2006.01.002.

    Article  Google Scholar 

  321. Ritter MA, Stringer EA. Bilateral total hip arthroplasty: a single procedure. Clin Orthop Relat Res. 1980;149:185–90.

    Google Scholar 

  322. Robertsson O, Borgquist L, Knutson K, Lewold S, Lidgren L. Use of unicompartmental instead of tricompartmental prostheses for arthrosis in the knee is a cost-effective alternative. Acta Orthop Scand. 1999;70:170–5. https://doi.org/10.3109/17453679909011257.

    Article  CAS  PubMed  Google Scholar 

  323. Rothwell MP, Pearson D, Hunter JD, Mitchell PA, Graham-Woollard T, Goodwin L, et al. Oral oxycodone offers equivalent analgesia to intravenous patient-controlled analgesia after total hip replacement: a randomized, single-centre, non-blinded, non-inferiority study. Br J Anaesth. 2011;106(6):865–72. https://doi.org/10.1093/bja/aer084.

    Article  CAS  PubMed  Google Scholar 

  324. Rottger J, Scheller-Kreinsen D, Busse R. Patient-level hospital costs and length of stay after conventional versus minimally invasive total hip replacement: a propensity-matched analysis. Value Health. 2012;15(8):999–1004. https://doi.org/10.1016/j.jval.2012.06.008.

    Article  PubMed  Google Scholar 

  325. Ruiz D Jr, Koenig L, Dall TM, Gallo P, Narzikul A, Parvizi J, et al. The direct and indirect costs to society of treatment for end-stage knee osteoarthritis. J Bone Joint Surg Am. 2013;95(16):1473–80. https://doi.org/10.2106/jbjs.L.01488.

    Article  PubMed  Google Scholar 

  326. Ryttberg L, Diamantopoulos A, Forster F, Lees M, Fraschke A, Bjorholt I. Cost-effectiveness of rivaroxaban versus heparins for prevention of venous thromboembolism after total hip or knee surgery in Sweden. Exp Rev Pharmacoecon Outcomes Res. 2011;11(5):601–15. https://doi.org/10.1586/erp.11.65.

    Article  Google Scholar 

  327. Sabeh KG, Rosas S, Buller LT, Roche MW, Hernandez VH. The impact of discharge disposition on episode-of-care reimbursement after primary total hip arthroplasty. J Arthroplast. 2017;32(10):2969–73. https://doi.org/10.1016/j.arth.2017.04.062.

    Article  Google Scholar 

  328. Sah AP. Is there an advantage to knotless barbed suture in TKA wound closure? A randomized trial in simultaneous bilateral TKAs. Clin Orthop Relat Res. 2015;473(6):2019–27. https://doi.org/10.1007/s11999-015-4157-5.

    Article  PubMed  PubMed Central  Google Scholar 

  329. Saito S, Tokuhashi Y, Ishii T, Mori S, Hosaka K, Taniguchi S. One- versus two-stage bilateral total hip arthroplasty. Orthopedics. 2010;33(8). https://doi.org/10.3928/01477447-20100625-07.

  330. Sakamoto B, Keiser S, Meldrum R, Harker G, Freese A. Efficacy of liposomal bupivacaine infiltration on the management of total knee arthroplasty. JAMA Surg. 2017;152(1):90–5. https://doi.org/10.1001/jamasurg.2016.3474.

    Article  PubMed  Google Scholar 

  331. Saleh KJ, Wood KC, Gafni A, Gross AE. Immediate surgery versus waiting list policy in revision total hip arthroplasty. An economic evaluation. J Arthroplast. 1997;12(1):1–10. https://doi.org/10.1016/s0883-5403(97)90040-1.

    Article  CAS  Google Scholar 

  332. Sambandam SN, Khanna V, Rohinikumar G, Mounasamy V. Pre-discharge postoperative radiographs after primary total knee replacement : tradition or science? Acta Orthop Belg. 2017;83(1):132–9.

    CAS  PubMed  Google Scholar 

  333. Sanz-Ruiz P, Matas-Diez JA, Sanchez-Somolinos M, Villanueva-Martinez M, Vaquero-Martin J. Is the commercial antibiotic-loaded bone cement useful in prophylaxis and cost saving after knee and hip joint arthroplasty? The transatlantic paradox. J Arthroplast. 2017;32(4):1095–9. https://doi.org/10.1016/j.arth.2016.11.012.

    Article  Google Scholar 

  334. Sarasin FP, Bounameaux H. Antithrombotic strategy after total hip replacement. A cost-effectiveness analysis comparing prolonged oral anticoagulants with screening for deep vein thrombosis. Arch Intern Med. 1996;156(15):1661–8. https://doi.org/10.1001/archinte.156.15.1661.

    Article  CAS  PubMed  Google Scholar 

  335. Sarasin FP, Bounameaux H. Out of hospital antithrombotic prophylaxis after total hip replacement: low-molecular-weight heparin, warfarin, aspirin or nothing? A cost-effectiveness analysis. Thromb Haemost. 2002;87(4):586–92.

    CAS  PubMed  Google Scholar 

  336. Saunders ME, Grant RE. Cost effectiveness of low-molecular weight heparin versus warfarin following hip replacement surgery. J Natl Med Assoc. 1998;90(11):677–80.

    CAS  PubMed  PubMed Central  Google Scholar 

  337. Scardino M, Di Matteo B, Martorelli F, Tanzi D, Kon E, D'Amato T. Improved patient blood management and cost saving in hip replacement surgery through the implementation of pre-operative sucrosomial(R) iron supplementation: a quality improvement assessment study. Int Orthop. 2019;43(1):39–46. https://doi.org/10.1007/s00264-018-4149-7.

    Article  PubMed  Google Scholar 

  338. Schousboe JT, Brown GA. Cost-effectiveness of low-molecular-weight heparin compared with aspirin for prophylaxis against venous thromboembolism after total joint arthroplasty. J Bone Joint Surg Am. 2013;95(14):1256–64. https://doi.org/10.2106/jbjs.L.00400.

    Article  PubMed  Google Scholar 

  339. Segal L, Day SE, Chapman AB, Osborne RH. Can we reduce disease burden from osteoarthritis? Med J Aust. 2004;180(S5):S11–7.

    PubMed  Google Scholar 

  340. Shakespeare D, Jeffcote B. Unicondylar arthroplasty of the knee--cheap at half the price? Knee. 2003;10(4):357–61. https://doi.org/10.1016/s0968-0160(03)00046-2.

    Article  PubMed  Google Scholar 

  341. Sharifi E, Sharifi H, Morshed S, Bozic K, Diab M. Cost-effectiveness analysis of periacetabular osteotomy. J Bone Joint Surg Am. 2008;90(7):1447–56. https://doi.org/10.2106/jbjs.G.00730.

    Article  PubMed  Google Scholar 

  342. Shepperd S, Harwood D, Gray A, Vessey M, Morgan P. Randomised controlled trial comparing hospital at home care with inpatient hospital care. II: cost minimisation analysis. BMJ (Clin Res ed). 1998;316(7147):1791–6. https://doi.org/10.1136/bmj.316.7147.1791.

    Article  CAS  Google Scholar 

  343. Shih CH, Ho WB. One-stage versus two-stage bilateral autophor ceramic total hip arthroplasty. Clin Orthop Relat Res. 1985;193:141–5.

    Google Scholar 

  344. Shulman G, Grecula MJ, Hadjipavlou AG. Intraoperative autotransfusion in hip arthroplasty. Clin Orthop Relat Res. 2002;396:119–30. https://doi.org/10.1097/00003086-200203000-00021.

    Article  Google Scholar 

  345. Sibia US, Turcotte JJ, MacDonald JH, King PJ. The cost of unnecessary hospital days for medicare joint arthroplasty patients discharging to skilled nursing facilities. J Arthroplast. 2017;32(9):2655–7. https://doi.org/10.1016/j.arth.2017.03.058.

    Article  Google Scholar 

  346. Sigurdsson E, Siggeirsdottir K, Jonsson H Jr, Gudnason V, Matthiasson T, Jonsson BY. Early discharge and home intervention reduces unit costs after total hip replacement: results of a cost analysis in a randomized study. Int J Health Care Finance Econ. 2008;8(3):181–92. https://doi.org/10.1007/s10754-008-9036-0.

    Article  PubMed  Google Scholar 

  347. Skedgel C, Goeree R, Pleasance S, Thompson K, O'Brien B, Anderson D. The cost-effectiveness of extended-duration antithrombotic prophylaxis after total hip arthroplasty. J Bone Joint Surg Am. 2007;89(4):819–28. https://doi.org/10.2106/jbjs.F.00092.

    Article  PubMed  Google Scholar 

  348. Slover J, Espehaug B, Havelin LI, Engesaeter LB, Furnes O, Tomek I, et al. Cost-effectiveness of unicompartmental and total knee arthroplasty in elderly low-demand patients. A Markov decision analysis. J Bone Joint Surg Am. 2006;88(11):2348–55. https://doi.org/10.2106/jbjs.E.01033.

    Article  PubMed  Google Scholar 

  349. Slover J, Hoffman MV, Malchau H, Tosteson AN, Koval KJ. A cost-effectiveness analysis of the arthroplasty options for displaced femoral neck fractures in the active, healthy, elderly population. J Arthroplast. 2009;24(6):854–60. https://doi.org/10.1016/j.arth.2008.05.008.

    Article  Google Scholar 

  350. Slover JD, Rubash HE, Malchau H, Bosco JA. Cost-effectiveness analysis of custom total knee cutting blocks. J Arthroplast. 2012;27(2):180–5. https://doi.org/10.1016/j.arth.2011.04.023.

    Article  Google Scholar 

  351. Smith EL, DiSegna ST, Shukla PY, Matzkin EG. Barbed versus traditional sutures: closure time, cost, and wound related outcomes in total joint arthroplasty. J Arthroplast. 2014;29(2):283–7. https://doi.org/10.1016/j.arth.2013.05.031.

    Article  Google Scholar 

  352. Smith LK, Williams DH, Langkamer VG. Post-operative blood salvage with autologous retransfusion in primary total hip replacement. J Bone Joint Surg Br Vol. 2007;89(8):1092–7. https://doi.org/10.1302/0301-620x.89b8.18736.

    Article  CAS  Google Scholar 

  353. Smith WB 2nd, Steinberg J, Scholtes S, McNamara IR. Medial compartment knee osteoarthritis: age-stratified cost-effectiveness of total knee arthroplasty, unicompartmental knee arthroplasty, and high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc. 2017;25(3):924–33. https://doi.org/10.1007/s00167-015-3821-3.

    Article  PubMed  Google Scholar 

  354. So-Osman C. Cost-effectiveness of patient blood management methods in elective orthopaedic surgery. ISBT Sci Ser. 2015;10(S1):146–9. https://doi.org/10.1111/voxs.12154.

    Article  Google Scholar 

  355. So-Osman C, Nelissen RG, Koopman-van Gemert AW, Kluyver E, Pöll RG, Onstenk R, et al. Patient blood management in elective total hip- and knee-replacement surgery (part 2): a randomized controlled trial on blood salvage as transfusion alternative using a restrictive transfusion policy in patients with a preoperative hemoglobin above 13 g/dl. Anesthesiology. 2014;120(4):852–60. https://doi.org/10.1097/aln.0000000000000135.

    Article  CAS  PubMed  Google Scholar 

  356. Sobh AH, Siljander MP, Mells AJ, Koueiter DM, Moore DD, Karadsheh MS. Cost analysis, complications, and discharge disposition associated with simultaneous vs staged bilateral total knee arthroplasty. J Arthroplast. 2018;33(2):320–3. https://doi.org/10.1016/j.arth.2017.09.004.

    Article  Google Scholar 

  357. Soohoo NF, Sharifi H, Kominski G, Lieberman JR. Cost-effectiveness analysis of unicompartmental knee arthroplasty as an alternative to total knee arthroplasty for unicompartmental osteoarthritis. J Bone Joint Surg Am. 2006;88(9):1975–82. https://doi.org/10.2106/jbjs.E.00597.

    Article  PubMed  Google Scholar 

  358. Spruill WJ, Wade WE, Leslie RB. Cost analysis of fondaparinux versus enoxaparin as venous thromboembolism prophylaxis in elective hip replacement surgery. Blood Coagul Fibrinolysis. 2004;15(7):539–43. https://doi.org/10.1097/00001721-200410000-00002.

    Article  PubMed  Google Scholar 

  359. Spruill WJ, Wade WE, Leslie RB. A cost analysis of fondaparinux versus enoxaparin in total knee arthroplasty. Am J Ther. 2004;11(1):3–8. https://doi.org/10.1097/00045391-200401000-00004.

    Article  PubMed  Google Scholar 

  360. Srivastava K, Bozic KJ, Silverton C, Nelson AJ, Makhni EC, Davis JJ. Reconsidering strategies for managing chronic periprosthetic joint infection in total knee arthroplasty: using decision analytics to find the optimal strategy between one-stage and two-stage total knee revision. J Bone Joint Surg Am. 2019;101(1):14–24. https://doi.org/10.2106/jbjs.17.00874.

    Article  PubMed  Google Scholar 

  361. Stan G, Orban H, Orban C. Cost effectiveness analysis of knee osteoarthritis treatment. Chirurgia (Bucharest, Romania : 1990). 2015;110(4):368–74.

    CAS  Google Scholar 

  362. Steuten L, Vallejo-Torres L, Bastide P, Buxton M. Analysing uncertainty around costs of innovative medical technologies: the case of fibrin sealant (QUIXIL) for total knee replacement. Health Policy (Amsterdam, Netherlands). 2009;89(1):46–57. https://doi.org/10.1016/j.healthpol.2008.05.002.

    Article  Google Scholar 

  363. Straumann D, Valderrabano V, Eckstein M, Dick W, Dora C. Cost-benefit analysis of MIS THA: model-based analysis of the consequences for Switzerland. Hip Int. 2006;16(Suppl 4):54–7. https://doi.org/10.5301/hip.2008.3456.

    Article  PubMed  Google Scholar 

  364. Strauss JB, Chen SS, Shah AP, Coon AB, Dickler A. Cost of radiotherapy versus NSAID administration for prevention of heterotopic ossification after total hip arthroplasty. Int J Radiat Oncol Biol Phys. 2008;71(5):1460–4. https://doi.org/10.1016/j.ijrobp.2007.12.006.

    Article  PubMed  Google Scholar 

  365. Stundner O, Poeran J, Ladenhauf HN, Berger MM, Levy SB, Zubizarreta N, et al. Effectiveness of intravenous acetaminophen for postoperative pain management in hip and knee arthroplasties: a population-based study. Reg Anesth Pain Med. 2019;44(5):565–72. https://doi.org/10.1136/rapm-2018-100145.

    Article  PubMed  Google Scholar 

  366. Suter LG, Paltiel AD, Rome BN, Solomon DH, Thornhill TS, Abrams SK, et al. Placing a price on medical device innovation: the example of total knee arthroplasty. PLoS One. 2013;8(5):e62709. https://doi.org/10.1371/journal.pone.0062709.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  367. Tan Z, Cao G, Wang G, Zhou Z, Pei F. Total hospital cost, length of stay, and complications between simultaneous and staged bilateral total hip arthroplasty: a nationwide retrospective cohort study in China. Medicine. 2019;98(11):e14687. https://doi.org/10.1097/md.0000000000014687.

    Article  PubMed  PubMed Central  Google Scholar 

  368. Teeter MG, Marsh JD, Howard JL, Yuan X, Vasarhelyi EM, McCalden RW, et al. A randomized controlled trial investigating the value of patient-specific instrumentation for total knee arthroplasty in the Canadian healthcare system. Bone Joint J. 2019;101-b(5):565–72. https://doi.org/10.1302/0301-620x.101b5.Bjj-2018-1323.R1.

    Article  CAS  PubMed  Google Scholar 

  369. Tibesku CO, Hofer P, Portegies W, Ruys CJ, Fennema P. Benefits of using customized instrumentation in total knee arthroplasty: results from an activity-based costing model. Arch Orthop Trauma Surg. 2013;133(3):405–11. https://doi.org/10.1007/s00402-012-1667-4.

    Article  PubMed  Google Scholar 

  370. Tille E, Mysliwietz J, Beyer F, Postler A, Lützner J. Intraarticular use of tranexamic acid reduces blood loss and transfusion rate after primary total knee arthroplasty. BMC Musculoskelet Disord. 2019;20(1):341. https://doi.org/10.1186/s12891-019-2715-9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  371. Ting NT, Moric MM, Della Valle CJ, Levine BR. Use of knotless suture for closure of total hip and knee arthroplasties: a prospective, randomized clinical trial. J Arthroplast. 2012;27(10):1783–8. https://doi.org/10.1016/j.arth.2012.05.022.

    Article  Google Scholar 

  372. Tomeczkowski J, Stern S, Muller A, von Heymann C. Potential cost saving of Epoetin alfa in elective hip or knee surgery due to reduction in blood transfusions and their side effects: a discrete-event simulation model. PLoS One. 2013;8(9):e72949. https://doi.org/10.1371/journal.pone.0072949.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  373. Tousignant M, Moffet H, Nadeau S, Merette C, Boissy P, Corriveau H, et al. Cost analysis of in-home telerehabilitation for post-knee arthroplasty. J Med Internet Res. 2015;17(3):e83. https://doi.org/10.2196/jmir.3844.

    Article  PubMed  PubMed Central  Google Scholar 

  374. Trahey PJ. A comparison of the cost-effectiveness of two types of occupational therapy services. Am J Occup Ther. 1991;45(5):397–400. https://doi.org/10.5014/ajot.45.5.397.

    Article  CAS  PubMed  Google Scholar 

  375. Tripuraneni KR, Carothers JT, Junick DW, Archibeck MJ. Cost comparison of cementless versus cemented hemiarthroplasty for displaced femoral neck fractures. Orthopedics. 2012;35(10):e1461–4. https://doi.org/10.3928/01477447-20120919-12.

    Article  PubMed  Google Scholar 

  376. Tse BK, Walters TL, Howard SK, Kim TE, Memtsoudis SG, Sun EC, et al. A matched case-control comparison of hospital costs and outcomes for knee replacement patients admitted postoperatively to acute care versus rehabilitation. J Anesth. 2017;31(5):785–8. https://doi.org/10.1007/s00540-017-2372-9.

    Article  PubMed  Google Scholar 

  377. Tso P, Walker K, Mahomed N, Coyte PC, Rampersaud YR. Comparison of lifetime incremental cost:utility ratios of surgery relative to failed medical management for the treatment of hip, knee and spine osteoarthritis modelled using 2-year postsurgical values. Can J Surg. 2012;55(3):181–90. https://doi.org/10.1503/cjs.033910.

    Article  PubMed  PubMed Central  Google Scholar 

  378. Tuominen U, Sintonen H, Hirvonen J, Seitsalo S, Paavolainen P, Lehto M, et al. Is longer waiting time for total knee replacement associated with health outcomes and medication costs? Randomized clinical trial. Value Health. 2010;13(8):998–1004. https://doi.org/10.1111/j.1524-4733.2010.00779.x.

    Article  PubMed  Google Scholar 

  379. Turajane T, Chaweevanakorn U, Sungkhun P, Larbphiboonpong V, Wongbunnak R. Cost-utility analysis and economic burden of knee osteoarthritis treatment: the analysis from the real clinical practice. J Med Assoc Thail. 2012;95(Suppl 10):S98–104.

    Google Scholar 

  380. Tuttle JR, Ritterman SA, Cassidy DB, Anazonwu WA, Froehlich JA, Rubin LE. Cost benefit analysis of topical tranexamic acid in primary total hip and knee arthroplasty. J Arthroplast. 2014;29(8):1512–5. https://doi.org/10.1016/j.arth.2014.01.031.

    Article  Google Scholar 

  381. Ververeli PA, Masonis JL, Booth RE, Hozack WJ, Rothman RH. Radiographic cost reduction strategy in total joint arthroplasty. A prospective analysis. J Arthroplast. 1996;11(3):277–80. https://doi.org/10.1016/s0883-5403(96)80078-7.

    Article  CAS  Google Scholar 

  382. Ververeli PA, Sutton DC, Hearn SL, Booth RE Jr, Hozack WJ, Rothman RR. Continuous passive motion after total knee arthroplasty. Analysis of cost and benefits. Clin Orthop Relat Res. 1995;321:208–15.

    Google Scholar 

  383. Vigna-Taglianti F, Basso L, Rolfo P, Brambilla R, Vaccari F, Lanci G, et al. Tranexamic acid for reducing blood transfusions in arthroplasty interventions: a cost-effective practice. Eur J Orthop Surg Traumatol. 2014;24(4):545–51. https://doi.org/10.1007/s00590-013-1225-y.

    Article  PubMed  Google Scholar 

  384. Vogt NH, Bothner U, Lerch G, Lindner KH, Georgieff M. Large-dose administration of 6% hydroxyethyl starch 200/0.5 total hip arthroplasty: plasma homeostasis, hemostasis, and renal function compared to use of 5% human albumin. Anesth Analg. 1996;83(2):262–8. https://doi.org/10.1097/00000539-199608000-00011.

    Article  CAS  PubMed  Google Scholar 

  385. Wammack L, Mabrey JD. Outcomes assessment of total hip and total knee arthroplasty: critical pathways, variance analysis, and continuous quality improvement. Clin Nurse Spec. 1998;12(3):122–9; quiz 30-1. https://doi.org/10.1097/00002800-199805000-00012.

    Article  CAS  PubMed  Google Scholar 

  386. Watters TS, Mather RC 3rd, Browne JA, Berend KR, Lombardi AV Jr, Bolognesi MP. Analysis of procedure-related costs and proposed benefits of using patient-specific approach in total knee arthroplasty. J Surg Orthop Adv. 2011;20(2):112–6.

    PubMed  Google Scholar 

  387. Weaver FM, Hughes SL, Almagor O, Wixson R, Manheim L, Fulton B, et al. Comparison of two home care protocols for total joint replacement. J Am Geriatr Soc. 2003;51(4):523–8. https://doi.org/10.1046/j.1532-5415.2003.51162.x.

    Article  PubMed  Google Scholar 

  388. Weeks CA, Marsh JD, MacDonald SJ, Graves S, Vasarhelyi EM. Patellar resurfacing in total knee arthroplasty: a cost-effectiveness analysis. J Arthroplast. 2018;33(11):3412–5. https://doi.org/10.1016/j.arth.2018.07.001.

    Article  Google Scholar 

  389. Willis-Owen CA, Brust K, Alsop H, Miraldo M, Cobb JP. Unicondylar knee arthroplasty in the UK National Health Service: an analysis of candidacy, outcome and cost efficacy. Knee. 2009;16(6):473–8. https://doi.org/10.1016/j.knee.2009.04.006.

    Article  PubMed  Google Scholar 

  390. Winegar AL, Jackson LW, Sambare TD, Liu TC, Banks SR, Erlinger TP, et al. A surgeon scorecard is associated with improved value in elective primary hip and knee arthroplasty. J Bone Joint Surg Am. 2019;101(2):152–9. https://doi.org/10.2106/jbjs.17.01553.

    Article  PubMed  Google Scholar 

  391. Wolowacz SE, Roskell NS, Maciver F, Beard SM, Robinson PA, Plumb JM, et al. Economic evaluation of dabigatran etexilate for the prevention of venous thromboembolism after total knee and hip replacement surgery. Clin Ther. 2009;31(1):194–212. https://doi.org/10.1016/j.clinthera.2009.01.001.

    Article  PubMed  Google Scholar 

  392. Wolowacz SE, Roskell NS, Plumb JM, Clemens A, Noack H, Robinson PA, et al. Economic evaluation of dabigatran etexilate for the prevention of venous thromboembolism in patients aged over 75 years or with moderate renal impairment undergoing total knee or hip replacement. Thromb Haemost. 2010;103(2):360–71. https://doi.org/10.1160/th09-08-0579.

    Article  CAS  PubMed  Google Scholar 

  393. Wood TJ, Alzahrani M, Marsh D, Somerville LE, Vasarhelyi EM, Lanting BA. Use of the Corail stem for revision total hip arthroplasty: evaluation of clinical outcomes and cost. Can J Surg. 2019;62(2):78–82. https://doi.org/10.1503/cjs.002318.

    Article  PubMed  PubMed Central  Google Scholar 

  394. Wood TJ, Leighton J, Backstein DJ, Marsh JD, Howard JL, McCalden RW, et al. Synthetic graft compared with allograft reconstruction for extensor mechanism disruption in total knee arthroplasty: a multicenter cohort study. J Am Acad Orthop Surg. 2019;27(12):451–7. https://doi.org/10.5435/jaaos-d-18-00393.

    Article  PubMed  Google Scholar 

  395. Worland RL, Arredondo J, Angles F, Lopez-Jimenez F, Jessup DE. Home continuous passive motion machine versus professional physical therapy following total knee replacement. J Arthroplast. 1998;13(7):784–7. https://doi.org/10.1016/s0883-5403(98)90031-6.

    Article  CAS  Google Scholar 

  396. Wyles CC, Robinson WA, Maradit-Kremers H, Houdek MT, Trousdale RT, Mabry TM. Cost and patient outcomes associated with bilateral total knee arthroplasty performed by 2-surgeon teams vs a single surgeon. J Arthroplast. 2019;34(4):671–5. https://doi.org/10.1016/j.arth.2018.12.029.

    Article  Google Scholar 

  397. Xie F, Lo NN, Tarride JE, O'Reilly D, Goeree R, Lee HP. Total or partial knee replacement? Cost-utility analysis in patients with knee osteoarthritis based on a 2-year observational study. Eur J Health Econ. 2010;11(1):27–34. https://doi.org/10.1007/s10198-009-0154-5.

    Article  PubMed  Google Scholar 

  398. Yan X, Gu X, Xu Z, Lin H, Wu B. Cost-effectiveness of different strategies for the prevention of venous thromboembolism after total hip replacement in China. Adv Ther. 2017;34(2):466–80. https://doi.org/10.1007/s12325-016-0460-0. A full economic evaluation of a decision tree model comparing various prophylaxis (enoxaparin, rivaroxaban and Apixaban) after total hip arthroplasty that scored a perfect 100 on the quality of health economics studies (QHES) tool. The paper provides a great reference for researchers when designing studies and drafting manuscripts or for critical appraisal of studies.

  399. Yin D, Delisle J, Banica A, Senay A, Ranger P, Laflamme GY, et al. Tourniquet and closed-suction drains in total knee arthroplasty. No beneficial effects on bleeding management and knee function at a higher cost. Orthop Traumatol Surg Res. 2017;103(4):583–9. https://doi.org/10.1016/j.otsr.2017.03.002.

    Article  CAS  PubMed  Google Scholar 

  400. Younger AS, MacLean S, Daniels TR, Penner MJ, Wing KJ, Dunbar M, et al. Initial hospital-related cost comparison of total ankle replacement and ankle fusion with hip and knee joint replacement. Foot Ankle Int. 2015;36(3):253–7. https://doi.org/10.1177/1071100714558844.

    Article  PubMed  Google Scholar 

  401. Yuan X, Li B, Wang Q, Zhang X. Comparison of 3 routes of administration of tranexamic acid on primary unilateral total knee arthroplasty: a prospective, randomized, controlled study. J Arthroplast. 2017;32(9):2738–43. https://doi.org/10.1016/j.arth.2017.03.059.

    Article  Google Scholar 

  402. Zhao H, Xiang M, Xia Y, Shi X, Pei FX, Kang P. Efficacy of oral tranexamic acid on blood loss in primary total hip arthroplasty using a direct anterior approach: a prospective randomized controlled trial. Int Orthop. 2018;42(11):2535–42. https://doi.org/10.1007/s00264-018-3846-6.

    Article  PubMed  Google Scholar 

  403. Zhou L, Ma J, Bao J. Effect of pharmacist intervention on blood conservation therapy in total knee arthroplasty: a retrospective, observational study. Basic Clin Pharmacol Toxicol. 2019;124(6):681–90. https://doi.org/10.1111/bcpt.13181.

    Article  CAS  PubMed  Google Scholar 

  404. Zimmerma S, Hawkes WG, Hudson JI, Magaziner J, Hebel JR, Towheed T, et al. Outcomes of surgical management of total HIP replacement in patients aged 65 years and older: cemented versus cementless femoral components and lateral or anterolateral versus posterior anatomical approach. J Orthop Res. 2002;20(2):182–91. https://doi.org/10.1016/s0736-0266(01)00090-0.

    Article  PubMed  Google Scholar 

  405. Zindel S, Stock S, Muller D, Stollenwerk B. A multi-perspective cost-effectiveness analysis comparing rivaroxaban with enoxaparin sodium for thromboprophylaxis after total hip and knee replacement in the German healthcare setting. BMC Health Serv Res. 2012;12:192. https://doi.org/10.1186/1472-6963-12-192.

    Article  PubMed  PubMed Central  Google Scholar 

  406. Stevens ER, Farrell D, Jumkhawala SA, Ladapo JA. Quality of health economic evaluations for the ACC/AHA stable ischemic heart disease practice guideline: a systematic review. Am Heart J. 2018;204:17–33. https://doi.org/10.1016/j.ahj.2018.06.013.

    Article  PubMed  Google Scholar 

  407. Peterson LE, Goodman C, Karnes EK, Chen CJ, Schwartz JA. Assessment of the quality of cost analysis literature in physical therapy. Phys Ther. 2009;89(8):733–55. https://doi.org/10.2522/ptj.20080326.

    Article  PubMed  Google Scholar 

  408. Defourny N, Monten C, Grau C, Lievens Y, Perrier L. Critical review and quality-assessment of cost analyses in radiotherapy: how reliable are the data? Radiother Oncol. 2019;141:14–26. https://doi.org/10.1016/j.radonc.2019.09.020.

    Article  PubMed  Google Scholar 

  409. Primeau CA, Marsh JD, Birmingham TB, Giffin JR. The importance of costing perspective: an example evaluating the cost-effectiveness of a locking versus nonlocking plate in medial opening wedge high tibial osteotomy. Can J Surg. 2019;62(1):E14–e6. https://doi.org/10.1503/cjs.018317.

    Article  PubMed  PubMed Central  Google Scholar 

  410. Hoch JS, Dewa CS. A clinician's guide to correct cost-effectiveness analysis: think incremental not average. Can J Psychiatry. 2008;53(4):267–74. https://doi.org/10.1177/070674370805300408.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jacquelyn D. Marsh PhD.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Key points

• Evaluating cost-effectiveness of interventions is critical for providing value-based care for patients yet only 1 in 3 studies investigating costs within the hip and knee arthroplasty literature meet the criteria of a full economic evaluation necessary to appropriately draw conclusions on cost-effectiveness and inform policy decision-making.

• Few studies (8%) compared surgical to non-surgical interventions.

• Cost-effectiveness of treatments may be dependent on the perspective analyzed; therefore, transparency in reporting the costing perspective is necessary as overall costs vary substantially in the proportion of direct and indirect costs.

• Consumers of economic evaluations in hip and knee arthroplasty literature need to assess the methodological quality of evidence, as many studies inappropriately conclude an intervention is “cost-effective” despite not conducting a full economic evaluation.

This article is part of the Topical Collection on Osteoarthritis

Electronic supplementary material

ESM 1

(DOCX 226 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Primeau, C.A., Joshi, I., Zomar, B.O. et al. Cost-Effectiveness of Arthroplasty Management in Hip and Knee Osteoarthritis: a Quality Review of the Literature. Curr Treat Options in Rheum 6, 160–190 (2020). https://doi.org/10.1007/s40674-020-00157-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40674-020-00157-8

Keywords

Navigation