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Probiotic, Paraprobiotic, and Hydrolyzed Yeast Mixture Supplementation Has Comparable Effects to Zinc Oxide in Improving Growth Performance and Ameliorating Post-weaning Diarrhea in Weaned Piglets

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Abstract

A total of 150 21-day-old weaned piglets [(Yorkshire × Landrace) × Duroc] were randomly assigned to 3 groups (CON, TRT1, TRT2) to evaluate the effects of dietary supplementation of probiotic, paraprobiotic, and hydrolyzed yeast mixture (PPY) on growth performance, nutrient digestibility, fecal bacterial counts, fecal calprotectin contents, and diarrhea rate in a 42-day experiment (phase 1: days 1–14; phase 2: days 15–42). There were 10 replicate pens per treatment with 5 pigs per pen (three gilts and two barrows). Pigs in CON were only provided with a basal diet. Pigs in TRT1 were provided with a basal diet + 3000 mg/kg zinc oxide during phase 1 and a basal diet during phase 2. Pigs in TRT2 were provided with a basal diet + 200 mg/kg probiotic (Saccharomyces cerevisiae boulardii) + 800 mg/kg paraprobiotic (inactivated yeast strains of Saccharomyces cerevisiae and Cyberlindnera jadinii) + 10 g/kg hydrolyzed yeast mixture during phase 1, and a basal diet + 100 mg/kg probiotic + 400 mg/kg paraprobiotic mixture during phase 2. Pigs in TRT1 and TRT2 were significantly heavier at day 14 and 42 than CON pigs. Growth rate during days 1–14, 15–42, and 1–42 and feed efficiency during days 1–14 were similarly affected by treatment while feed efficiency was significantly higher for TRT2 pigs between 15–42 and 1–42 days. Moreover, nitrogen and energy digestibility in both TRT1 and TRT2 were higher than that in CON. During experimental periods, diarrhea rate in TRT1 and TRT2 was lower than that in CON. Therefore, we demonstrated that PPY supplementation had comparable effects as ZnO in improving growth performance and nutrient digestibility as well as ameliorating post-weaning diarrhea in weaned piglets.

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Abbreviations

ADG:

Average daily gain

ADFI:

Average daily feed intake

ATTD:

Apparent total tract digestibility

DM:

Dry matter

PPY:

Probiotic, paraprobiotic, and hydrolyzed yeast mixture

ZnO:

Zinc oxide

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Authors and Affiliations

  1. Department of Animal Resource & Science, Dankook University, Cheonan, South Korea

    De Xin Dang, Si Yeong Choi & In Ho Kim

  2. Lallemand SAS, 19 Rue de Briquetiers, 31702, Blagnac, France

    Si Yeong Choi, Mathieu Castex, Eric Chevaux, David Saornil, Fernando Bravo de Laguna & Guillermo Jimenez

  3. Bioanalysis and Pharmacokinetics Research Group, Korea Institute of Toxicology, Daejeon, South Korea

    Young Jae Choi & Jong Hwa Lee

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  1. De Xin Dang
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Contributions

Conceptualization: Mathieu Castex, Eric Chevaux, David Saornil, and Fernando Bravo de Laguna; data curation: De Xin Dang and In Ho Kim; formal analysis: Si Young Choi, Young Jae Choi, and Jong Hwa Lee; investigation: De Xin Dang, Si Young Choi, Young Jae Choi, and Jong Hwa Lee; methodology: Mathieu Castex, Eric Chevaux, David Saornil, Fernando Bravo de Laguna, and In Ho Kim; software: De Xin Dang, Mathieu Castex, Eric Chevaux, David Saornil, Fernando Bravo de Laguna, and Guillermo Jimenez; supervision: In Ho Kim; roles/writing original draft: De Xin Dang; writing, review, and editing: De Xin Dang.

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Dang, D.X., Choi, S.Y., Choi, Y.J. et al. Probiotic, Paraprobiotic, and Hydrolyzed Yeast Mixture Supplementation Has Comparable Effects to Zinc Oxide in Improving Growth Performance and Ameliorating Post-weaning Diarrhea in Weaned Piglets. Probiotics & Antimicro. Prot. 16, 249–258 (2024). https://doi.org/10.1007/s12602-022-10008-8

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