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Progress and prospects of chiral nanomaterials for biosensing platforms

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Abstract

Chiral nanomaterials have distinct chiroptical properties of preferential interactions to circularly polarized lights. Chirality-based biosensors have emerged for detection of biomolecules, ions and cells in recent years. This review provides an extensive overview of biosensors based on chiral nanomaterials, starting with approaches to chiral nanomaterials construction in terms of fabrication strategies. Fabrication of chiral nanomaterials and their biosensor applications is presented for different material types, with special emphasis on the role and importance of material properties and signal generation in detection. We assessed the technological prospects of the emerging fields of chiral construction, circularly polarized luminescence, Raman optical activity and so on along with their current challenges. Prospective venues for future research on chiral nanomaterials in fabrication, biosensing, disease diagnosis and treatment are also presented in the review.

Graphical abstract

摘要

手性纳米材料具有与圆偏振光优先相互作用的独特手性特性。近年来出现了基于手性的生物传感器, 用于检测生物分子、金属离子和细胞。本综述从手性纳米材料的制造策略入手, 广泛概述了基于手性纳米材料的生物传感器。介绍了不同材料类型的手性纳米材料的制造及其生物传感器应用, 特别强调了材料特性和信号产生在检测中的作用和重要性。我们评估了手性构造、圆偏振发光和拉曼光学活性等新兴领域的技术前景及其当前面临的挑战。综述还介绍了手性纳米材料在制造、生物传感、疾病诊断和治疗方面的未来研究前景。

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (No. 22272065), the Natural Science Foundation of Jiangsu Province (No. BK20211530), the Fundamental Research Funds for the Central Universities (No. JUSRP622018) and the Key Research and Development Special Project of Gao'an City, Jiangxi Province, China (No. 2023ZDYFZX06).

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Authors and Affiliations

  1. School of Food Science and Technology, State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China

    Yu-Cheng Ouyang & Wei Ma

  2. Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, 214122, China

    Yu-Cheng Ouyang & Yuan Zhao

  3. Department of Chemical Engineering, Hanyang University, Seoul, 04763, Republic of Korea

    Bong-Jun Yeom

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  3. Yuan Zhao
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Ouyang, YC., Yeom, BJ., Zhao, Y. et al. Progress and prospects of chiral nanomaterials for biosensing platforms. Rare Met. 43, 2469–2497 (2024). https://doi.org/10.1007/s12598-023-02602-8

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