Abstract
The importance of feeding as a vital physiological function, on the one hand, and the spread of complications induced by its disorder in humans and animals, on the other hand, have led to extensive research on its regulatory factors. Unfortunately, despite many studies focused on appetite, only limited experiments have been conducted on avian, and our knowledge of this species is scant. Considering this, the purpose of this review article is to examine the role of central neurotransmitters in regulating food consumption in broilers and layers and highlight the similarities and differences between these two strains. The methodology of this review study includes a comprehensive search of relevant literature on the topic using appropriate keywords in reliable electronic databases. Based on the findings, the central effect of most neurotransmitters on the feeding of broilers and laying chickens was similar, but in some cases, such as dopamine, ghrelin, nitric oxide, and agouti-related peptide, differences were observed. Also, the lack of conducting a study on the role of some neurotransmitters in one of the bird strains made it impossible to make an exact comparison. Finally, it seems that although there are general similarities in appetite regulatory mechanisms in meat and egg-type chickens, the long-term genetic selection appropriate to breeding goals (meat or egg production) has caused differences in the effect of some neurotransmitters. Undoubtedly, conducting future studies while completing the missing links can lead to a comprehensive understanding of this process and its manipulation according to the breeding purposes of chickens.
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References
Abbasnejad M, Jonaidi H, Denbow DM, Pour Rahimi AM (2005) Feeding and locomotion responses to centrally injected nociceptin/orphanin FQ in chicks. Physiol Behav 85(4):383–386. https://doi.org/10.1016/j.physbeh.2005.03.016
Abolghasempour S, Panahi N, Gilanpour H, Zendedel M, Jahandideh A (2021) Role of nitrergic systems in feed intake induced by nociceptin/orphanin FQ in neonatal meat-type chickens. Iran J Physiol Pharmacol 5:127–134
Ahmadian-Moghadam H, Sadat-Shirazi MS, Zarrindast MR (2018) Cocaine-and amphetamine-regulated transcript (CART): a multifaceted neuropeptide. Peptides 110:56–77. https://doi.org/10.1016/j.peptides.2018.10.008
Akalu Y, Molla MD, Dessie G, Ayelign B (2020) Physiological effect of ghrelin on body systems. Int J Endocrinol 2020:1385138. https://doi.org/10.1155/2020/1385138
Alizadeh A, Zendehdel M, Babapour V, Charkhkar S, Hassanpour S (2015) Role of cannabinoidergic system on food intake in neonatal layer-type chicken. Vet Res Commun 39(2):151–157. https://doi.org/10.1007/s11259-015-9636-3
Alvarez BD, Morales CA, Amodeo DA (2021) Impact of specific serotonin receptor modulation on behavioral flexibility. Pharmacol Biochem Behav 209:173243. https://doi.org/10.1016/j.pbb.2021.173243
Alves A, Bassot A, Bulteau AL, Pirola L, Morio B (2019) Glycine metabolism and its alterations in obesity and metabolic diseases. Nutrients 11(6):1356. https://doi.org/10.3390/nu11061356
Amini Zadeh R, Jonaidi H, Esmaeili Mahani S, Salehi M, Emam Bakhsh M (2023) Effects of intracerebroventricular injection of apelin-13 on food intake in broiler chicks. Vet Res Forum 14(2):105–108. https://doi.org/10.30466/vrf.2022.545646.3335
Ampofo E, Nalbach L, Menger MD, Laschke MW (2020) Regulatory mechanisms of somatostatin expression. Int J Mol Sci 21(11):4170. https://doi.org/10.3390/ijms21114170
Anjum S, Khattak MNK, Tsutsui K, Krishna A (2021) RF-amide related peptide-3 (RFRP-3): a novel neuroendocrine regulator of energy homeostasis, metabolism, and reproduction. Mol Biol Rep 48:1837–1852. https://doi.org/10.1007/s11033-021-06198-z
Aston-Jones G, Cohen JD (2005) An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Annu Rev Neurosci 28:403–450. https://doi.org/10.1146/annurev.neuro.28.061604.135709
Baghaeikia S, Fallah H, Khodadadi M, Yousefvand S, Mahdavi K, Zendehdel M et al (2022) Opioid receptor μ, not δ and κ, modulate food intake induced by ghrelin in laying chickens. Can J Physiol Pharmacol 100(10):983–992. https://doi.org/10.1139/cjpp-2022-0061
Baghbanzadeh A, Babapour V (2007) Glutamate ionotropic and metabotropic receptors affect feed intake in broiler cockerels. Iran J Vet Med 1(1):125–129. https://doi.org/10.22059/ijvm.2008.65776
Baghbanzadeh A, Hamidiya Z, Geranmayeh MH (2015) Involvement of central β-adrenergic circuitry in food and water intake in chickens. Neurophysiology 47:128–132
Boswell T, Dunn IC (2017) Regulation of Agouti-related protein and pro-Opiomelanocortin gene expression in the avian arcuate nucleus. Front Endocrinol 8:75. https://doi.org/10.3389/fendo.2017.00075
Bouret SG (2022) Developmental programming of hypothalamic melanocortin circuits. Exp Mol Med 54(4):403–413. https://doi.org/10.1038/s12276-021-00625-8
Brady S, Siegel G, Albers RW, Price DL (eds) (2005) Basic neurochemistry: molecular, cellular and medical aspects. Elsevier, Boston
Bromée T, Sjödin P, Fredriksson R, Boswell T, Larsson TA, Salaneck E et al (2006) Neuropeptide Y-family receptors Y6 and Y7 in chicken. FEBS J 273:2048–2063. https://doi.org/10.1111/j.1742-4658.2006.05221.x
Bungo T, Shimojo M, Masuda Y, Tachibanab T, Tanaka S, Sugahara K et al (1999) Intracerebroventricular administration of mouse leptin does not reduce food intake in the chicken. Brain Res 817(1–2):196–198. https://doi.org/10.1016/s0006-8993(98)01223-2
Bungo T, Kawamura K, Izumi T, Dodo K, Ueda H (2004) Feeding responses to mu-, delta- and kappa-opioid receptor agonists in the meat-type chick. Pharmacol Biochem Behav 78(4):707–710. https://doi.org/10.1016/j.pbb.2004.05.015
Bungo T, Dodo K, Kawamura K, Izumi T, Ueda H (2005) Effects of various mu- and delta-opioid ligands on food intake in the meat-type chick. Physiol Behav 85(5):519–523. https://doi.org/10.1016/j.physbeh.2005.05.015
Bungo T, Yahata K, Izumi T, Dodo K, Yanagita K, Shiraishi J et al (2008) Centrally administered tryptophan suppresses food intake in free fed chicks through the serotonergic system. J Poult Sci 45(3):215–219. https://doi.org/10.2141/jpsa.45.215
Bungo T, Shiraishi J, Yanagita K, Ohta Y, Fujita M (2009) Effect of nociceptin/orphanin FQ on feeding behavior and hypothalamic neuropeptide expression in layer-type chicks. Gen Comp Endocrinol 163(1–2):47–51. https://doi.org/10.1016/j.ygcen.2009.03.009
Bungo T, Yanagita K, Shiraishi JI (2010) Feed intake after infusion of noradrenalin, dopamine or its. J Anim Vet Adv 9:760–763
Burgos CF, Yévenes GE, Aguayo LG (2016) Structure and pharmacologic modulation of inhibitory Glycine receptors. Mol Pharmacoly 90(3):318–325. https://doi.org/10.1124/mol.116.105726
Buzala M, Janicki B (2016) Effects of different growth rates in broiler breeder and layer hens on some productive traits. Poult Sci 95(9):2151–2159. https://doi.org/10.3382/ps/pew173
Camerino C (2023) The long way of oxytocin from the uterus to the heart in 70 years from its discovery. Int J Mol Sci 24(3):2556. https://doi.org/10.3390/ijms24032556
Campos A, Port JD, Acosta A (2022) Integrative hedonic and homeostatic food intake regulation by the central nervous system: insights from neuroimaging. Brain Sci 12(4):431. https://doi.org/10.3390/brainsci12040431
Carter CS, Kenkel WM, MacLean EL, Wilson SR, Perkeybile AM, Yee JR et al (2020) Is oxytocin “Nature’s medicine”? Pharmacol Rev 72(4):829–861. https://doi.org/10.1124/pr.120.019398
Cetin H, Beeson D, Vincent A, Webster R (2020) The structure, function, and physiology of the fetal and adult acetylcholine receptor in muscle. Front Mol Neurosci 13:581097. https://doi.org/10.3389/fnmol.2020.581097
Chen ZR, Huang JB, Yang SL, Hong FF (2022) Role of cholinergic signaling in Alzheimer’s disease. Molecules 27(6):1816. https://doi.org/10.3390/molecules27061816
Chudoba R, Dabrowska J (2023) Distinct populations of corticotropin-releasing factor (CRF) neurons mediate divergent yet complementary defensive behaviors in response to a threat. Neuropharmacology 228:109461. https://doi.org/10.1016/j.neuropharm.2023.109461
Corleto VD, Nasoni S, Panzuto F, Cassetta S, Delle Fave G (2004) Somatostatin receptor subtypes: basic pharmacology and tissue distribution. Dig Liver Dis 36(Suppl 1):S8–S16. https://doi.org/10.1016/j.dld.2003.11.008
Couvineau A, Nicole P, Gratio V, Voisin T (2022) The orexin receptors: structural and anti-tumoral properties. Front Endocrinol 13:931970. https://doi.org/10.3389/fendo.2022.931970
Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL et al (2003) The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37(4):649–661. https://doi.org/10.1016/s0896-6273(03)00063-1
Cox MA, Bassi C, Saunders ME, Nechanitzky R, Morgado-Palacin I, Zheng C et al (2020) Beyond neurotransmission: acetylcholine in immunity and inflammation. J Intern Med 287(2):120–133. https://doi.org/10.1111/joim.13006
Daneshvar M, Zendehdel M, Vazir B, Asghari A (2022) Correlation of histamine receptors and adrenergic receptor in broilers appetite. Arch Razi Inst 77(1):141–149. https://doi.org/10.22092/ARI.2021.354450.1638
Dautzenberg FM, Grigoriadis DE, Hauger RL, Risbrough VB, Steckler T, Vale WW et al (2023) Corticotropin-releasing factor receptors in GtoPdb v. 2023.1. IUPHAR/BPS guide to pharmacology CITE. 2023(1). https://doi.org/10.2218/gtopdb/F19/2023.1
De Oliveira AA, Vergara A, Wang X, Vederas JC, Oudit GY (2022) Apelin pathway in cardiovascular, kidney, and metabolic diseases: therapeutic role of apelin analogs and apelin receptor agonists. Peptides 147:170697. https://doi.org/10.1016/j.peptides.2021.170697
Della-Fera MA, Baile CA (1980) CCK-octapeptide injected in CSF decreases meal size and daily food intake in sheep. Peptides 1(1):51–54. https://doi.org/10.1016/0196-9781(80)90035-2
Denbow DM, Cline M (2015) Sturkie’s Avian physiology, 6th edn. Academic Press, San Diego
Denbow DM, Sheppard BJ (1993) Food and water intake responses of the domestic fowl to norepinephrine infusion at circumscribed neural sites. Brain Res Bull 31(1–2):121–128. https://doi.org/10.1016/0361-9230(93)90018-7
Denbow DM, Van Krey HP, Skewes PA, Lacy MP (1985) Food and water intake of broiler chicks as affected by intracerebroventricular injections of cholinomimetics. Poult Sci 64(5):991–994. https://doi.org/10.3382/ps.0640991
Denbow DM, Snapir N, Furuse M (1999) Inhibition of food intake by CRF in chickens. Physiol Behav 66(4):645–649. https://doi.org/10.1016/s0031-9384(98)00340-0
Denbow DM, Meade S, Robertson A, McMurtry JP, Richards M, Ashwell C (2000) Leptin-induced decrease in food intake in chickens. Physiol Behav 69(3):359–362. https://doi.org/10.1016/s0031-9384(99)00258-9
Dridi S, Ververken C, Hillgartner FB, Arckens L, Van der Gucht E, Cnops L et al (2006) FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an) orexigenic neuropeptides in chickens. (Erratum vol 291, pg R138, 2006). Am J Physiol Regul Integr Comp Physiol 291(3):R860–R860. https://doi.org/10.1152/ajpregu.00899.2005
Duan J, Shen DD, Zhao T, Guo S, He X, Yin W et al (2022) Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors. Nat Commun 13(1):1364. https://doi.org/10.1038/s41467-022-29072-3
El Daibani A, Che T (2022) Spotlight on nociceptin/orphanin FQ receptor in the treatment of pain. Molecules 27(3):595. https://doi.org/10.3390/molecules27030595
Emadi L, Jonaidi H, Hosseini Amir Abad E (2011) The role of central CB2 cannabinoid receptors on food intake in neonatal chicks. J Comp Physiol A: Neuroethol Sens Neural Behav Physiol 197(12):1143–1147. https://doi.org/10.1007/s00359-011-0676-z
Farzin M, Hassanpour S, Zendehdel M, Vazir B, Asghari A (2022) Effects of intracerebroventricular injection of spexin and its interaction with NPY, GalR2 and GalR3 receptors on the central food intake regulation and nutritional behavior in broiler chickens. Neurosci Lett 777:136589. https://doi.org/10.1016/j.neulet.2022.136589
Findeisen M, Rathmann D, Beck-Sickinger AG (2011) RFamide peptides: structure, function, mechanisms and pharmaceutical potential. Pharmaceuticals 4(9):1248–1280. https://doi.org/10.3390/ph4091248
Friedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395(6704):763–770. https://doi.org/10.1038/27376
Froemke RC, Young LJ (2021) Oxytocin, neural plasticity, and social behavior. Annu Rev Neurosci 44:359–381. https://doi.org/10.1146/annurev-neuro-102320-102847
Furuse M, Ando R, Bungo T, Ao R, Shimojo M, Masuda Y (1999) Intracerebroventricular injection of orexins does not stimulate food intake in neonatal chicks. Br Poult Sci 40(5):698–700. https://doi.org/10.1080/00071669987115
Giordani G, Cattabriga G, Becchimanzi A, Di Lelio I, De Leva G, Gigliotti S et al (2023) Role of neuronal and non-neuronal acetylcholine signaling in Drosophila humoral immunity. Insect Biochem Mol Biol 153:103899. https://doi.org/10.1016/j.ibmb.2022.103899
Goshi E, Zhou G, He Q (2019) Nitric oxide detection methods in vitro and in vivo. Med Gas Res 9(4):192. https://doi.org/10.4103/2045-9912.273957
Gray SM, Page LC, Tong J (2019) Ghrelin regulation of glucose metabolism. J Neuroendocrinol 31(7):e12705. https://doi.org/10.1111/jne.12705
Greene ES, Abdelli N, Dridi JS, Dridi S (2022) Avian neuropeptide Y: beyond feed intake regulation. Vet Sci 9(4):171. https://doi.org/10.3390/vetsci9040171
Grim TW, Acevedo-Canabal A, Bohn LM (2020) Toward directing opioid receptor signaling to refine opioid therapeutics. Biol Psychiatry 87(1):15–21. https://doi.org/10.1016/j.biopsych.2019.10.020
Grimier K, Altmann HM, Straub AC, Isenberg JS (2017) Nitric oxide: what’s new to NO? Am J Physiol Cell Physiol 312(3):C254–C262. https://doi.org/10.1152/ajpcell.00315.2016
Gropp E, Shanabrough M, Borok E, Xu AW, Janoschek R, Buch T et al (2005) Agouti-related peptide–expressing neurons are mandatory for feeding. Nat Neurosci 8(10):1289–1291. https://doi.org/10.1038/nn1548
Hagen CJ, Newmyer BA, Webster RI, Gilbert ER, Siegel PB, Tachibana T et al (2013) Stimulation of food intake after central galanin is associated with arcuate nucleus activation and does not differ between genetically selected low and high body weight lines of chickens. Neuropeptides 47(4):281–285. https://doi.org/10.1016/j.npep.2012.11.003
Hamidi B, Zendehdel M, Vazir B, Asghari A (2022) The effect of the central administration of the neuropeptide VF on feed intake and its possible interactions with glutamate and opioid systems in broiler chicken. Int J Pept Res Ther 28(3):101. https://doi.org/10.1007/s10989-022-10407-z
Hassanpour S, Zendehdel M, Babapour V, Charkhkar S (2015) Endocannabinoid and nitric oxide interaction mediates food intake in neonatal chicken. Br Poult Sci 56(4):443–451. https://doi.org/10.1080/00071668.2015.1059407
Hen G, Yosefi S, Simchaev V, Shinder D, Hruby VJ, Friedman-Einat M (2006) The melanocortin circuit in obese and lean strains of chicks. J Endocrinol 190(2):527–535. https://doi.org/10.1677/joe.1.06783
Honda K, Saneyasu T, Hasegawa S, Kamisoyama H (2012) A comparative study of the central effects of melanocortin peptides on food intake in broiler and layer chicks. Peptides 37(1):13–17. https://doi.org/10.1016/j.peptides.2012.06.015
Hone AJ, McIntosh JM (2023) Nicotinic acetylcholine receptors: therapeutic targets for novel ligands to treat pain and inflammation. Pharmacol Res 190:106715. https://doi.org/10.1016/j.phrs.2023.106715
Hu G, Wang Z, Zhang R, Sun W, Chen X (2021) The role of apelin/apelin receptor in energy metabolism and water homeostasis: a comprehensive narrative review. Front Physiol 12:632886. https://doi.org/10.3389/fphys.2021.632886
Ilnytska O, Argyropoulos G (2008) The role of the Agouti-related protein in energy balance regulation. Cell Mol Life Sci 65(17):2721. https://doi.org/10.1007/s00018-008-8104-4
Jaefari-Anari M, Zendehdel M, Gilanpour H, Asghari A, Babapour V (2018) Central opioidergic system interplay with histamine on food intake in neonatal chicks: role of μ-opioid and H1/H3 receptors. Braz J Poul Sci 20:595–604
Jelokhani M, Vazir B, Zendehdel M, Jahandideh A (2022) Interactions of cholecystokinin and glutamatergic systems in feeding behavior of neonatal chickens. Arch Razi Inst 77(2):681–688. https://doi.org/10.22092/ARI.2022.357300.2015
Ji LQ, Hong Y, Tao YX (2022) Melanocortin-5 receptor: pharmacology and its regulation of energy metabolism. Int J Mol Sci 23(15):8727. https://doi.org/10.3390/ijms23158727
Jiao ZT, Luo Q (2022) Molecular mechanisms and health benefits of ghrelin: a narrative review. Nutrients 14(19):4191. https://doi.org/10.3390/nu14194191
Jing XZ, Yang HJ, Taximaimaiti R, Wang XP (2023) Advances in the therapeutic use of non-ergot dopamine agonists in the treatment of motor and non-motor symptoms of Parkinson's disease. Curr Neuropharmacol 21(5):1224–1240. https://doi.org/10.2174/1570159X20666220915091022
Jonaidi H, Babapour V, Denbow DM (2002) GABAergic control of food intake in the meat-type chickens. Physiol Behav 76(4–5):465–468. https://doi.org/10.1016/s0031-9384(02)00692-3
Jonaidi H, Oloumi MM, Denbow DM (2003) Behavioral effects of intracerebroventricular injection of oxytocin in birds. Physiol Behave 79(4–5):725–729. https://doi.org/10.1016/s0031-9384(03)00145-8
Jones D (2011) An appetite for connection: why we need to understand the effect and value of feeding wild birds. Emu 111(2):1–7. https://doi.org/10.1071/MUv111n2_ED
Kaiya H, Saito ES, Tachibana T, Furuse M, Kangawa K (2007) Changes in ghrelin levels of plasma and proventriculus and ghrelin mRNA of proventriculus in fasted and refed layer chicks. Domes Anim Endocrinol 32:247–259. https://doi.org/10.1016/j.domaniend.2006.03.006
Kaiya H, Miyazato M, Kangawa K (2011) Recent advances in the phylogenetic study of ghrelin. Peptides 32(11):2155–2174. https://doi.org/10.1016/j.peptides.2011.04.027
Katayama S, Hamasu K, Shigemi K, Cline MA, Furuse M (2010a) Intracerebroventricular injection of orexin-A, but not orexin-B, induces arousal of layer-type neonatal chicks. Comp Biochem Physiol A Mol Integr Physiol 157(2):132–135. https://doi.org/10.1016/j.cbpa.2010.05.018
Katayama S, Tomonaga S, Sato M, Yamane H, Tsuneyoshi Y, Denbow DM et al (2010b) Norepinephrine does not alter NPY and POMC mRNA expression in neonatal chicks. Comp Biochem Physiol A Mol Integr Physiol 156(1):143–146. https://doi.org/10.1016/j.cbpa.2010.01.011
Kelesidis T, Kelesidis I, Chou S, Mantzoros C (2010) Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med 152(2):93–100. https://doi.org/10.7326/0003-4819-152-2-201001190-00008
Kerrigan S, Goldberger BA (2020) Opioids. In: Levine BS, Kerrigan S (eds) Principles of Forensic Toxicology, 5th edn. Springer, Switzerland. https://doi.org/10.1007/978-3-030-42917-1_22
Khan MS, Tachibana T, Hasebe Y, Masuda N, Ueda H (2007) Peripheral or central administration of nitric oxide synthase inhibitor affects feeding behavior in chicks. Comp Biochem Physiol A Mol Integr Physiol 148(2):458–462. https://doi.org/10.1016/j.cbpa.2007.06.006
Khan MSI, Ohkubo T, Masuda N, Tachibana T, Ueda H (2009) Central administration of metastin increases food intake through opioid neurons in chicks. Comp Biochem Physiol A Mol Integr Physiol 153(2):209–212. https://doi.org/10.1016/j.cbpa.2009.02.013
Khodadadi M, Zendehdel M, Baghbanzadeh A, Babapour V (2017) Consequence of dopamine D2 receptor blockade on the hyperphagic effect induced by cannabinoid CB1 and CB2 receptors in layers. Br Poult Sci 58(5):585–593. https://doi.org/10.1080/00071668.2017.1357799
Kiguchi N, Ding H, Kishioka S, Ko MC (2020) Nociceptin/orphanin FQ peptide receptor-related ligands as novel analgesics. Curr top medl chem 20(31):2878–2888. https://doi.org/10.2174/1568026620666200508082615
Kim MS, Rossi M, Abusnana S, Sunter D, Morgan DG, Small CJ et al (2000) Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone. Diabetes 49(2):177–182. https://doi.org/10.2337/diabetes.49.2.177
Kołodziejski PA, Pruszyńska-Oszmałek E, Hejdysz M, Sassek M, Leciejewska N, Ziarniak K et al (2021) Effect of fasting on the spexin system in broiler chickens. Animals (Basel) 11(2):518. https://doi.org/10.3390/ani11020518
Kord A, Vazir B, Zendedel Kheybari M, Babapour V, Asghari A (2022) Interaction of central kisspeptin with melanocortin, GABAergic, corticotrophin, and NPY systems on food intake in chickens. Iran J Vet Sci Technol 14(2):19–28. https://doi.org/10.22067/ijvst.2022.74653.1109
Li J, Tian Y, Wu A (2015) Neuropeptide Y receptors: a promising target for cancer imaging and therapy. Regen Biomater 2(3):215–219. https://doi.org/10.1093/rb/rbv013
Lundberg JO, Weitzberg E (2022) Nitric oxide signaling in health and disease. Cell 185(16):2853–2878. https://doi.org/10.1016/j.cell.2022.06.010
Lv SY, ZhouYC ZXM, Chen WD, Wang YD (2019) Emerging roles of NPQ/spexin in physiology and pathology. Front Pharmacol 10:457. https://doi.org/10.3389/fphar.2019.00457
Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y et al (2017) Structural basis for apelin control of the human apelin receptor. Structure 25(6):858–866. https://doi.org/10.1016/j.str.2017.04.008
Mahdavi K, Zendehdel M, Baghbanzadeh A (2023) Central effects of opioidergic system on food intake in birds and mammals: a review. Vet Res Commun 47(3):1103–1114. https://doi.org/10.1007/s11259-023-10142-w
Mahzouni M, Zendehdel M, Babapour V, Charkhkar S (2016) Methylamine induced hypophagia is mediated via dopamine D1 and D2 receptors in neonatal meat chicks. Vet Res Commun 40:21–27. https://doi.org/10.1007/s11259-015-9649-y
Marcos P, Coveñas R (2021) Neuropeptidergic control of feeding: focus on the Galanin family of peptides. Int J Mol Sci 22(5):2544. https://doi.org/10.3390/ijms22052544
Maslami V, Nur YS, Marlida Y (2019) Effect of glutamate supplementation as a feed additive on performance of broiler chickens. J World’s Poult Res 9(3):154–159. https://doi.org/10.36380/jwpr.2019.19
McConn BR, Koskinen A, Denbow DM, Gilbert ER, Siegel PB, Cline MA (2019) Central injection of oxytocin reduces food intake and affects hypothalamic and adipose tissue gene expression in chickens. Domes Anim Endocrinol 67:11–20. https://doi.org/10.1016/j.domaniend.2018.10.005
McCormack JF, Denbow DM (1987) The effects of opioid antagonists on ingestive behavior in the domestic fowl. Pharmacol Biochem Behav 27(1):25–33. https://doi.org/10.1016/0091-3057(87)90472-2
McCormack JF, Denbow DM (1988) Feeding, drinking and temperature responses to intracerebroventricular beta-endorphin in the domestic fowl. Peptides 9:09–715. https://doi.org/10.1016/0196-9781(88)90110-6
Meng Q, Kim HC, Oh S, Lee YM, Hu Z, Oh KW (2018) Cocaine- and amphetamine-regulated transcript (CART) peptide plays critical role in psychostimulant-induced depression. Biomol Ther 26(5):425–431. https://doi.org/10.4062/biomolther.2018.141
Miller GD (2017) Appetite regulation: hormones, peptides, and neurotransmitters and their role in obesity. Am J Lifestyle Med 13(6):586–601. https://doi.org/10.1177/1559827617716376
Mills EG, Izzi-Engbeaya C, Abbara A, Comninos AN, Dhillo WS (2021) Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour. Nat Rev Endocrinol 17(2):97–113. https://doi.org/10.1038/s41574-020-00438-1
Miyasaka K, Funakoshi A (2003) Cholecystokinin and cholecystokinin receptors. J Gastroenterol 38(1):1–13. https://doi.org/10.1007/s005350300000
Mobarhan Fard M, Vazir B, Zendehdel M, Asghari A (2021) Interaction of central glutamatergic and histaminergic systems on food intake regulation in layer chickens. Arch Razi Inst 76(3):537–551. https://doi.org/10.22092/ari.2020.351260.1513
Mohapatra SS, Mukherjee J, Banerjee D, Das PK, Ghosh PR, Das K (2021) RFamide peptides, the novel regulators of mammalian HPG axis: a review. Vet World 14(7):1867. https://doi.org/10.14202/vetworld.2021.1867-1873
Moosadoost Y, Zendehdel M, Khodadadi M (2021) The effect of rfamide-related peptide-3 (RFRP-3 or NPVF) on food intake in neonatal chickens: the role of MC3/MC4 and CRF 1/CRF 2 receptors. Int J Pep Res Ther 27:253–262. https://doi.org/10.1007/s10989-020-10081-z
Mortezaei SS, Zendehdel M, Babapour V, Hasani K (2013) The role of glutamatergic and GABAergic systems on serotonin- induced feeding behavior in chicken. Vet Res Commun 37(4):303–310. https://doi.org/10.1007/s11259-013-9576-8
Mutluay SU, Karataş H (2022) A review of glutamate and its receptors: their roles in brain physiology and pathology. Acta Med Austriaca 53(2):99–109. https://doi.org/10.32552/2022.ActaMedica.650
Narayan A, Downey LA, Manning B, Hayley AC (2022) Cannabinoid treatments for anxiety: a systematic review and consideration of the impact of sleep disturbance. Neurosci Biobehav Rev 143:104941. https://doi.org/10.1016/j.neubiorev.2022.104941
Ohgushi A, Bungo T, Shimojo M, Masuda Y, Denbow DM, Furuse M (2001) Relationships between feeding and locomotion behaviors after central administration of CRF in chicks. Physiol Behav 72(1–2):287–289. https://doi.org/10.1016/s0031-9384(00)00377-2
Parsons ME, Ganellin CR (2006) Histamine and its receptors. Br J Pharmacol 147 Suppl 1(Suppl 1):S127–S135. https://doi.org/10.1038/sj.bjp.0706440
Pourrahimi M, Panahi N, Babapour V, Asghari A (2019) Intracerebroventricular injection of NMDA receptor antagonist affects l-arginine induced food intake in neonatal layer chicks. Int J Pep Res Ther 25:739–748. https://doi.org/10.1007/s10989-018-9720-y
Prokop JW, Duff RJ, Ball HC, Copeland DL, Londraville RL (2012) Leptin and leptin receptor: analysis of a structure to function relationship in interaction and evolution from humans to fish. Peptides 38(2):326–336. https://doi.org/10.1016/j.peptides.2012.10.002
Rahimi J, Zendehdel M, Khodadadi M (2021) The role of Glycine and strychnine-sensitive receptors on food intake induced with dopamine in neonatal broilers. J Vet Res 76(2):233–241. https://doi.org/10.22059/jvr.2020.300449.3043
Rahmani B, Mahdavi K, Zendedel Kheybari M, Khodadadi M, Keshavarz M, Shahabi M, Baghbanzadeh A (2022) Role of central opioid receptors on serotonin-induced hypophagia in the neonatal broilers. Iran J Vet Sci Technol 14(1):9–19. https://doi.org/10.22067/ijvst.2022.72134.1071
Raji-Dahmardeh F, Vazir B, Zendehdel M, Asghari A, Panahi N (2020) Interaction between oxytocin and opioidergic system on food intake regulation in neonatal layer type chicken. Int J Pept Res Ther 26:1905–1912. https://doi.org/10.1007/s10989-019-09944-x
Raybould HE (2007) Mechanisms of CCK signaling from gut to brain. Curr Opin Pharmacol 7(6):570–574. https://doi.org/10.1016/j.coph.2007.09.006
Reichmann F, Holzer P (2016) Neuropeptide Y: a stressful review. Neuropeptides 55:99–109. https://doi.org/10.1016/j.npep.2015.09.008
Rudnick G, Sandtner W (2019) Serotonin transport in the 21st century. J Gen Physiol 151(11):1248–1264. https://doi.org/10.1085/jgp.201812066
Saadoun A, Cabrera MC (2008) Hypophagic and dipsogenic effect of the 5-HT1A receptor agonist 8-OH-DPAT in broiler chickens. J Anim Physiol Anim Nutr (Berl) 92(5):597–604. https://doi.org/10.1111/j.1439-0396.2007.00754.x
Saadoun A, Alvarez AF, Cabrera-Saadoun MC (1997) Effect of acute histamine and pentagastrin on voluntary food intake in growing chickens. Appl Anim Behav Sci 55(1–2):129–136. https://doi.org/10.1016/s0168-1591(97)000
Safikhani A, Zendehdel M, Khodadadi M, Rahmani B, Ghashghayi E, Mahdavi K (2023) Hypophagia induced by intracerebroventricular injection of apelin-13 is mediated via CRF1/CRF2 and MC3/MC4 receptors in neonatal broiler chicken. Behav Brain Res 452:114536. https://doi.org/10.1016/j.bbr.2023.114536
Salceda R (2022) Glycine neurotransmission: Its role in development. Front Neurosci 16:947563. https://doi.org/10.3389/fnins.2022.947563
Saneyasu T, Honda K, Kamisoyama H, Ikura A, Nakayama Y, Hasegawa S (2011) Neuropeptide Y effect on food intake in broiler and layer chicks. Comp Biochem Physiol 159(4):422–426. https://doi.org/10.1016/j.cbpa.2011.04.008
Sashihara K, Bungo T, Ando R, Ohgushi A, Kawakami SI, Denbow DM et al (2002) Role of central serotonergic systems on the regulation of feeding behavior of chicks in two different strains. J Appl Anim Res 21(1):17–23
Schuller J, Koch M (2022) Investigating a role of orexin and ‘cocaine-and amphetamine-regulated transcript’in the nucleus accumbens shell in binge eating of male rats and the relationship with impulsivity. Physiol Behav 257:114000. https://doi.org/10.1016/j.physbeh.2022.114000
Şener K, Alver EN, Cevher ŞC (2022) An overview of appetite regulation mechanisms. Kocaeli J Sci Eng 5(2):178–193. https://doi.org/10.34088/kojose.1091078
Seroussi E, Knytl M, Pitel F, Elleder D, Krylov V, Leroux S et al (2019) Avian expression patterns and genomic mapping implicate leptin in digestion and TNF in immunity, suggesting that their interacting Adipokine role has been acquired only in mammals. Int J Mol Sci 20(18):4489. https://doi.org/10.3390/ijms20184489
Shahbazi F, Grandi V, Banerjee A, Trant JF (2020) Cannabinoids and cannabinoid receptors: the story so far. Iscience 23(7):101301. https://doi.org/10.1016/j.isci.2020.101301
Shamsi Biranvand Z, Mousavi SGR, Shamsollahi M, Cheraghi J, Taherpour K (2014) Effects of chlorpheniramine (histamine H1 receptor antagonist) on food and water intake in broiler chickens in hunger and satiety. Int J Adv Biol Biomed Res 2(2):321–327
Shamsi BH, Chatoo M, Xu XK, Xu X, Chen XQ (2021) Versatile functions of somatostatin and somatostatin receptors in the gastrointestinal system. Front Endocrinol 12:652363. https://doi.org/10.3389/fendo.2021.652363
Shende P, Desai D (2020) Physiological and therapeutic roles of neuropeptide Y on biological functions. Adv Exp Med Biol 1237:37–47. https://doi.org/10.1007/5584_2019_427
Shojaei M, Yousefi AR, Zendehdel M, Khodadadi M (2020) Food intake regulation in birds: the role of neurotransmitters and hormones. Iran J Vet Med 14(1):99–115. https://doi.org/10.22059/IJVM.2019.285059.1005006
Smolinska S, Winiarska E, Globinska A, Jutel M (2022) Histamine: a mediator of intestinal disorders—a review. Metabolites 12(10):895. https://doi.org/10.3390/metabo12100895
Song YH, Yoon J, Lee SH (2021) The role of neuropeptide somatostatin in the brain and its application in treating neurological disorders. Exp Mol Med 53(3):328–338. https://doi.org/10.1038/s12276-021-00580-4
Sternson SM, Atasoy D (2015) Agouti-related protein neuron circuits that regulate appetite. Neuroendocrinology 100(2–3):95–102. https://doi.org/10.1159/000369072
Sweeney P, Gimenez LE, Hernandez CC, Cone RD (2023) Targeting the central melanocortin system for the treatment of metabolic disorders. Nat Rev Endocrinol:1–13. https://doi.org/10.1038/s41574-023-00855-y
Taati M, Nayebzadeh H, Zendehdel M (2011) The effects of DL-AP5 and glutamate on ghrelin-induced feeding behavior in 3-h food-deprived broiler cockerels. J Physiol Biochem 67:217–223. https://doi.org/10.1007/s13105-010-0066-y
Tachibana T, Sugahara K, Ohgushi A, Ando R, Kawakami S, Yoshimatsu T et al (2001) Intracerebroventricular injection of agouti-related protein attenuates the anorexigenic effect of alpha-melanocyte stimulating hormone in neonatal chicks. Neurosci Lett 305(2):131–134. https://doi.org/10.1016/s0304-3940(01)01827-4
Tachibana T, Takagi T, Tomonaga S, Ohgushi A, Ando R, Denbow DM et al (2003) Central administration of cocaine- and amphetamine-regulated transcript inhibits food intake in chicks. Neurosci Lett 337(3):131–134. https://doi.org/10.1016/s0304-3940(02)01321-6
Tachibana T, Saito S, Tomonaga S, Takagi T, Saito ES, Nakanishi T et al (2004) Effect of central administration of prolactin-releasing peptide on feeding in chicks. Physiol Behav 80(5):713–719. https://doi.org/10.1016/j.physbeh.2003.12.005
Tachibana T, Mori M, Khan MSI, Ueda H, Sugahara K, Hiramatsu K (2008) Central administration of galanin stimulates feeding behavior in chicks. Comp Biochem Physiol A Mol Integr Physiol 151(4):637–640. https://doi.org/10.1016/j.cbpa.2008.08.001
Tachibana T, Cline MA, Sugahara K, Ueda H, Hiramatsu K (2009) Central administration of somatostatin stimulates feeding behavior in chicks. Gen Comp Endocrinol 161(3):354–359. https://doi.org/10.1016/j.ygcen.2009.01.022
Tachibana T, Matsuda K, Kawamura M, Ueda H, Khan MS, Cline MA (2012) Feeding-suppressive mechanism of sulfated cholecystokinin (26–33) in chicks. Comp Biochem Physiol A Mol Integr Physiol 161(4):372–378. https://doi.org/10.1016/j.cbpa.2011.12.010
Tang X, Jaenisch R, Sur M (2021) The role of GABAergic signalling in neurodevelopmental disorders. Nat Rev Neurosci 22(5):290–307. https://doi.org/10.1038/s41583-021-00443-x
Tran A, He W, Chen JT, Belsham DD (2022) Spexin: its role, regulation, and therapeutic potential in the hypothalamus. Pharmacol Ther 233:108033. https://doi.org/10.1016/j.pharmthera.2021.108033
Ubaldi M, Cannella N, Borruto AM, Petrella M, Micioni Di Bonaventura MV, Soverchia L et al (2021) Role of nociceptin/orphanin FQ-NOP receptor system in the regulation of stress-related disorders. Int J Mol Sci 22(23):12956. https://doi.org/10.3390/ijms222312956
Van Galen KA, Ter Horst KW, Serlie MJ (2021) Serotonin, food intake, and obesity. Obes Rev 22(7):e13210. https://doi.org/10.1111/obr.13210
Vosoughi A, Zendehdel M, Hassanpour S (2024) Central effects of the serotoninergic, GABAergic, and cholecystokinin systems on neuropeptide VF (NPVF)-induced hypophagia and feeding behavior in neonatal broiler chicken. Neurosci Lett 818:137557. https://doi.org/10.1016/j.neulet.2023.137557
Wang S (2019) Historical review: opiate addiction and opioid receptors. Cell Transplant 28(3):233–238. https://doi.org/10.1177/0963689718811060
Wang L, Tran A, Lee J, Belsham DD (2020) Palmitate differentially regulates Spexin, and its receptors Galr2 and Galr3, in GnRH neurons through mechanisms involving PKC, MAPKs, and TLR4. Mol Cell Endocrinol 518:110991. https://doi.org/10.1016/j.mce.2020.110991
Willard SS, Koochekpour S (2013) Glutamate, glutamate receptors, and downstream signaling pathways. Int J Biol Sci 9(9):948. https://doi.org/10.7150/ijbs.6426
Wu Y, Zeng L, Zhao S (2021) Ligands of adrenergic receptors: a structural point of view. Biomolecules 11(7):936. https://doi.org/10.3390/biom11070936
Xu Z, Hu SW, Zhou Y, Guo Q, Wang D, Gao YH et al (2023) Corticotropin-releasing factor neurones in the paraventricular nucleus of the hypothalamus modulate isoflurane anaesthesia and its responses to acute stress in mice. Br J Anaesth 130(4):446–458. https://doi.org/10.1016/j.bja.2022.12.020
Yakovlev OA, Vengerovich NG, Nikiforov AS, Vakhviyaynen MS (2022) Pharmacological potential of ligands to receptors of RF-amide neuropeptide system. Pharm Formulas 4(1):10–17. https://doi.org/10.17816/phf108266
Yeo GSH, Chao DHM, Siegert AM, Koerperich ZM, Ericson MD, Simonds SE et al (2021) The melanocortin pathway and energy homeostasis: from discovery to obesity therapy. Mol Metabol 48:101206. https://doi.org/10.1016/j.molmet.2021.101206
Yousefi A, Shojaei M, Zendehdel M (2019) Evaluation the role of central serotonin and 5HT2c serotonin receptor on feed intake in female layer-type Bovans chicken by intracerebroventricular (ICV) injection of Para-chlorophenylalanine and SB242084. Vet Res Biol Products 32(1):55–62. https://doi.org/10.22092/vj.2018.122197.1466
Yousefvand S, Hamidi F, Zendehdel M, Parham A (2020) Survey the effect of insulin on modulating feed intake via NPY receptors in 5-day-old chickens. Int J Pept Res Ther 26:467–476. https://doi.org/10.1007/s10989-019-09852-0
Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F et al (2022) Structural insight into apelin receptor-G protein stoichiometry. Nat Struct Mol Biol 29(7):688–697. https://doi.org/10.1038/s41594-022-00797-5
Zeilhofer HU, Acuña MA, Gingras J, Yévenes GE (2018) Glycine receptors and glycine transporters: targets for novel analgesics? Cell Mol Life Sci 75(3):447–465. https://doi.org/10.1007/s00018-017-2622-x
Zendehdel M, Hassanpour S (2014) Central regulation of food intake in mammals and birds: a review. Neurotransmitter 1:1–7. https://doi.org/10.14800/nt.251
Zendehdel M, Baghbanzadeh A, Babapour V, Cheraghi J (2009) The effects of bicuculline and muscimol on glutamate-induced feeding behavior in broiler cockerels. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 195:715–720. https://doi.org/10.1007/s00359-009-0446-3
Zendehdel M, Mokhtarpouriani K, Babapour V, Baghbanzadeh A, Pourrahimi M, Hassanpour S (2013) The effect of serotonergic system on nociceptin/orphanin FQ induced food intake in chicken. J Physiol Sci 63(4):271–277. https://doi.org/10.1007/s12576-013-0263-x
Zendehdel M, Hasani K, Babapour V, Mortezaei SS, Khoshbakht Y, Hassanpour S (2014) Dopamine-induced hypophagia is mediated by D1 and 5HT-2c receptors in chicken. Vet Res Commun 38(1):11–19. https://doi.org/10.1007/s11259-013-9581-y
Zendehdel M, Khodadadi M, Zandieh H, Mokhtarpouriani K, Rahmani B, Baghbanzadeh A (2021) A newly discovered interference of the central nitrergic system on oxytocin-induced hypophagia in layer-type chickens. Iran J Vet Sci Technol 13(1). https://doi.org/10.22067/IJVST.2021.64318.0
Zhang R, Nakanishi T, Ohgushi A, Ando R, Yoshimatsu T, Denbow DM et al (2001) Suppression of food intake induced by corticotropin-releasing factor family in neonatal chicks. Eur J Pharmacol 427(1):37–41. https://doi.org/10.1016/s0014-2999(01)01109-8
Zhang W, Xiong BR, Zhang LQ, Huang X, Yuan X, Tian YK et al (2021) The role of the GABAergic system in diseases of the central nervous system. Neuroscience 470:88–99. https://doi.org/10.1016/j.neuroscience.2021.06.037
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Mahdavi, K., Zendehdel, M. & Zarei, H. The role of central neurotransmitters in appetite regulation of broilers and layers: similarities and differences. Vet Res Commun (2024). https://doi.org/10.1007/s11259-024-10312-4
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DOI: https://doi.org/10.1007/s11259-024-10312-4