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The role of glutamatergic and GABAergic systems on serotonin- induced feeding behavior in chicken

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Abstract

It has been reported that serotonin can modulate glutamate and GABA release in central nervous system (CNS). The present study was designed to examine the role of glutamatergic and GABAergic systems on serotonin- induced feeding behavior in chickens. In Experiment 1 intracerebroventricular (ICV) injection of MK- 801(NMDA receptor antagonist, 15 nmol) performed followed by serotonin (10 μg). In experiments 2, 3, 4, 5, 6 and 7 prior to serotonin injection, chickens received CNQX (AMPA/kainate receptor antagonist, 390 nmol), AIDA (mGluR1 antagonist, 2 nmol), LY341495 (mGluR2 antagonist, 150 nmol), UBP1112 (mGluR3 antagonist, 2 nmol), picrotoxin (GABA A receptor antagonist, 0.5 μg), CGP54626 (GABAB receptor antagonist, 20 ng) respectively. Cumulative food intake was determined at 3 h post injection. The results of this study showed that the hypophagic effect of serotonin was significantly attenuated by pretreatment with MK- 801 and CNQX (p < 0.05) but AIDA, LY341495 and UBP1112 had no effect (p > 0.05). Also, the inhibitory effect of serotonin on food intake was amplified by picrotoxin (p < 0.05) while CGP54626 had no effect (p > 0.05). These results suggest that serotonin as a modulator probably interacts with glutamatergic (via NMDA and AMPA/Kainate receptors) and GABAergic (via GABAA receptor) systems on feeding behavior in chicken.

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Acknowledgments

This research was supported by a grant from the Research Council of the Faculty of Veterinary Medicine, University of Tehran, Iran.

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Authors and Affiliations

  1. Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, PO Box: 14155-6453, Tehran, Iran

    Sepideh Seyedali Mortezaei, Morteza Zendehdel, Vahab Babapour & Keyvan Hasani

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  1. Sepideh Seyedali Mortezaei
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  2. Morteza Zendehdel
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  3. Vahab Babapour
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  4. Keyvan Hasani
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Correspondence to Morteza Zendehdel.

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Mortezaei, S.S., Zendehdel, M., Babapour, V. et al. The role of glutamatergic and GABAergic systems on serotonin- induced feeding behavior in chicken. Vet Res Commun 37, 303–310 (2013). https://doi.org/10.1007/s11259-013-9576-8

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  • DOI: https://doi.org/10.1007/s11259-013-9576-8

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