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Synthesis of N- and C-terpenylanilines and the study of their properties

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Abstract

Among various catalysts for the alkylation of aniline with camphene, aluminum phenolate was found to be the most effective for the synthesis of N-isobornylaniline. Studies of the antioxidant properties of terpenylanilines on various in vitro models revealed a significant dependence of their activity on the position and structure of the terpene moiety, the choice of the method for assessing the antioxidant properties being also dependent on their structure.

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Acknowledgements

The analysis of the synthesized compounds was carried out using the equipment of the Center for Collective Use “Chemistry” of the Institute of Chemistry of the Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences. The study of the activity of the compounds was carried out using the equipment of the Center for Collective Use “Molecular Biology” of the Institute of Biology of the Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences.

Funding

This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (State Assignments Nos 122040600073-3 and 122040600022-1).

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Authors and Affiliations

  1. Institute of Chemistry of Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, 48 ul. Pervomayskaya, 167000, Syktyvkar, Russian Federation

    I. Yu. Chukicheva, O. A. Shumova & A. V. Kutchin

  2. Institute of Biology of Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, 28 ul. Kommunisticheskaya, 167982, Syktyvkar, Russian Federation

    O. G. Shevchenko

Authors
  1. I. Yu. Chukicheva
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  2. O. A. Shumova
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  3. O. G. Shevchenko
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  4. A. V. Kutchin
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Corresponding author

Correspondence to I. Yu. Chukicheva.

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Animal Testing and Ethics

No human or animal subjects were used in this research. All studies were performed in vitro on tissues of intact laboratory mice. We used the tissues of laboratory mice from the scientific collection of experimental animals of the same institute (https://ckp-rf.ru/usu/471933/), which were kept in accordance with the “Regulations on the vivarium of experimental animals” (protocol No. 1 from January 24, 2017) taking into account the sanitary, hygienic and bioethical aspects.

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The authors declare no competing interests.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 73, No. 3, pp. 580–587, March, 2024.

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Chukicheva, I.Y., Shumova, O.A., Shevchenko, O.G. et al. Synthesis of N- and C-terpenylanilines and the study of their properties. Russ Chem Bull 73, 580–587 (2024). https://doi.org/10.1007/s11172-024-4168-z

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  • DOI: https://doi.org/10.1007/s11172-024-4168-z

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