Abstract
Piperidinium spirooxindoline-pyridineolate has been prepared via one-pot multicomponent reaction of isatin, malononitrile, cyanoacetohydrazide, and piperidine in water or ethanol medium at room temperature. In addition, the synthesis of two indole-substituted 2-pyridones from indole-3-carbaldehyde, malononitrile, and cyanoacetohydrazide in the presence of piperidine is described.
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Abbreviations
- TLC:
-
Thin-layer chromatography
- RT:
-
Room temperature
- MeCN:
-
Acetonitrile
- NR:
-
No reaction
- FT-IR:
-
Fourier-transform infrared
- MCR:
-
Multicomponent reaction
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Acknowledgements
We thank the Iran National Science Foundation (Grant No. 98004758) for financial support. We acknowledge the support of this research from Imam Khomeini International University.
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Mirzaei, F., Bayat, M. & Nasri, S. A one-pot synthesis of piperidinium spirooxindoline-pyridineolates and indole-substituted pyridones in aqueous or ethanol medium. Mol Divers 26, 2039–2048 (2022). https://doi.org/10.1007/s11030-021-10313-4
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DOI: https://doi.org/10.1007/s11030-021-10313-4