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Research advances in hydrogel-based wound dressings for diabetic foot ulcer treatment: a review

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Abstract

Diabetic foot ulcers (DFUs) are one of the most challenging and prevalent refractory wounds associated with diabetes mellitus. It is characterized with long courses, high recurrence and disability rates. Hydrogel-based wound dressings have been demonstrated an effective and promising strategy for treating diabetic wounds. However, the complexity of the pathogenesis and microenvironment in diabetic wounds have restricted both the experts in functional hydrogels and clinicians. The former had no inspiration for clinical demands in the design process, and the latter was confused about clinical use because they knew little about the tremendous potential of the functional hydrogels. Here, important targets for DFUs treatment were listed, and effective products underlying the molecular pathogenesis were suggested for the designer. Then, the application of hydrogels into DFUs were classified in accordance with their functional targets and active ingredients. Hence, it is very convenient for clinicians to make a perfect option for different wounds. Finally, research gaps and future prospects for wound-healing hydrogels were presented. We envision that this review can inspire creativity and innovation in the development of hydrogel-based wound dressings for diabetic foot ulcer treatment.

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Acknowledgements

This study was sponsored by the National Natural Science Fund (NO:81903994), Youth Development of the First Affiliated Hospital of Anhui Medical University (NO:2793), the Key projects of the clinical research of the First Affiliated Hospital of Anhui Medical University (NO: LCYJ2021ZD005), the Peak Discipline Construction Project of School of Public Health, Anhui Medical University (2021, 2022), Anhui Medical University College Students Innovation and Entrepreneurship Project (Provincial Project, 2022).

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Authors and Affiliations

  1. Department of Chinese Medicine, The First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, Shushan District, Hefei, 230032, Anhui, People’s Republic of China

    Jie Zhao & Yuxin Hu

  2. Department of Chinese Integrative Medicine, Anhui Medical University, No. 80, Meishan Road, Shushan District, Hefei, 230032, Anhui, People’s Republic of China

    Jie Zhao & Yuxin Hu

  3. Institute for Medical Virology, Goethe University Frankfurt Am Main, 60596, Frankfurt, Germany

    Jie Liu

  4. Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of China

    Wanxuan Hu & Yexiang Sun

  5. School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, People’s Republic of China

    Juan Wei

  6. Anhui Engineering Research Center for Medical Micro-Nano Devices, School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, 230011, People’s Republic of China

    Haisheng Qian

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  1. Jie Zhao
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The authors’ responsibilities were as follows: Jie zhao completed the collection and analysis of relevant literature and the preparation of the first draft of the thesis; Jie liu participated in graphics. Yuxin Hu and Wanxuan Hu participated in the analysis and collation of the literature. Juan Wei, Haisheng Qian and Yexiang Sun are the project creators and principals, and Yexiang Sun critically revised the manuscript for intellectual content, guiding the paper writing. All authors read and agreed to the final text.

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Zhao, J., Liu, J., Hu, Y. et al. Research advances in hydrogel-based wound dressings for diabetic foot ulcer treatment: a review. J Mater Sci 59, 8059–8084 (2024). https://doi.org/10.1007/s10853-024-09493-9

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