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Recent Advances in Bio-Inspired Versatile Polydopamine Platforms for “Smart” Cancer Photothermal Therapy

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Abstract

Although photothermal therapy (PTT) has been developed for fighting cancers, the degradative, toxic, and metabolic nature of photothermal conversion materials (PCMs) has prevented them from being clinically implemented. Taking advantage of the surface modification strategy of mussel-inspired dopamine chemistry and its excellent photothermal conversion effect, polydopamine (Pdop) represents a versatile PTT platform, providing strategies and methods for the construction of novel Pdop-functionalized PCMs. Thanks to its adhesion and secondary reactivity, Pdop can be deposited on virtually all substrates to improve their bioavailability and biocompatibility. Pdop-based PCMs could not be only functionalized with small biomolecules via chemical bonds and/or noncovalent force but also modified with functional polymers via either the “grafting to” or “grafting from” method. This review highlights the synthetic methods, therapeutic strategies, and designs of PCMs based on Pdop in recent years to explore its scope and limitations.

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Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (No. 52003047), the Science and Technology Commission of Shanghai Municipality (No. 20JC1414900), and the Fundamental Research Funds for the Central Universities (No. 2232020D-05).

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Authors and Affiliations

  1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China

    Zhi-Yuan Ma, Rui-Li Wang & Mei-Fang Zhu

  2. Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, 832003, China

    Dan-Ya Li & Xin Jia

Authors
  1. Zhi-Yuan Ma
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  2. Dan-Ya Li
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  3. Xin Jia
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  4. Rui-Li Wang
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  5. Mei-Fang Zhu
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Correspondence to Mei-Fang Zhu.

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The authors declare no competing financial interest.

Biography

Mei-Fang Zhu obtained her PhD degree in Materials Science in 1999 from Donghua University (DHU, Shanghai). Currently, she is a Professor at DHU and a member of the Chinese Academy of Science. She also serves as the Dean for the College of Materials Science and Engineering in DHU and the Director of the State Key Laboratory for Modification of Chemical Fibers and Polymer Materials. She has long been engaged in research on the fundamental chemistry, properties, and applications of fiber materials, organic/inorganic hybrid nano-materials, smart hydrogels and biomaterials for green energy, environment, and healthcare.

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Ma, ZY., Li, DY., Jia, X. et al. Recent Advances in Bio-Inspired Versatile Polydopamine Platforms for “Smart” Cancer Photothermal Therapy. Chin J Polym Sci 41, 699–712 (2023). https://doi.org/10.1007/s10118-023-2926-2

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