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Neues zu Tumoren der Speicheldrüsen

WHO-Klassifikation 2022

New information about tumours of the salivary glands

WHO classification 2022

  • Schwerpunkt: Kopf-Hals-Pathologie – neue WHO-Klassifikation
  • Published:
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Zusammenfassung

In der 5. Ausgabe der WHO-Klassifikation 2022 für Tumoren der Kopf-Hals-Region ist eine erneute leichte Zunahme bei benignen und malignen Tumorentitäten der Speicheldrüsen zu verzeichnen. Daneben gibt es sowohl konzeptionelle als auch rein terminologische Änderungen. Einige Festlegungen sind als vorläufig zu betrachten und einige weitere gelten als sehr umstritten (z. B. die Terminologie des intraduktalen Karzinoms). Die Bedeutung molekularpathologischer Befunde, insbesondere von rekurrenten Genfusionen, nimmt weiterhin stark zu und sie wurden teilweise in die Definition von Tumorentitäten aufgenommen. Ihre Bedeutung bleibt wie bisher weitgehend auf diagnostische Aspekte beschränkt. Zu den neu aufgenommenen Entitäten zählen das mikrosekretorische Karzinom (definiert durch eine SS18::MEF2C-Fusion), das sklerosierende mikrozystische Adenokarzinom (ähnelt den gleichnamigen Hautadnextumoren) und das muzinöse Adenokarzinom (charakterisiert durch AKT1-Mutationen bei heterogener Morphologie).

Abstract

The WHO 2022 classification of head and neck tumours contains another slight increase in the number of listed benign and malignant tumour entities of the salivary glands. This includes conceptual changes and alterations in the terminology of some entities. While some new features are regarded as preliminary or provisional, others are strongly disputed (for example the terminology of intraductal carcinoma). The impact of molecular findings, mainly recurrent gene fusions, continues to increase rapidly and some have been included in the definition of certain tumour entities. The significance of molecular findings is, however, still largely restricted to diagnostic aspects. Newly included entities include microsecretory carcinoma (defined by an SS18::MEF2C fusion), sclerosing microcystic adenocarcinoma (similar to skin adnexal tumours of the same name) and mucinous adenocarcinoma (characterized by AKT1 mutations with heterogeneous morphology).

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Authors and Affiliations

  1. DERMPATH München, Bayerstr. 69, 80335, München, Deutschland

    Stephan Ihrler & Christian Haas

  2. Pathologisches Institut, Ludwig-Maximilians-Universität, München, Deutschland

    Stephan Ihrler & Philipp Jurmeister

  3. Medizinische Fakultät, Zahnmedizin, Ludwig-Maximilians-Universität, München, Deutschland

    Lukas Greber

  4. Sanitätsunterstützungszentrum München, Bundeswehr, München, Deutschland

    Lukas Greber

  5. Institut für Pathologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Deutschland

    Abbas Agaimy

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  1. Stephan Ihrler
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  2. Philipp Jurmeister
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  3. Christian Haas
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  4. Lukas Greber
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  5. Abbas Agaimy
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Correspondence to Stephan Ihrler.

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Interessenkonflikt

S. Ihrler, P. Jurmeister, C. Haas, L. Greber und A. Agaimy geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

Additional information

Schwerpunktherausgeber

A. Agaimy, Erlangen

S. Ihrler, München

In Auszügen vorgetragen beim 575. Tutorial „Epitheliale Speicheldrüsentumoren“ der deutschen Abteilung der Internationalen Akademie für Pathologie (IAP) in Bonn 2022 sowie bei den Bamberger Morphologietagen 2022.

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Ihrler, S., Jurmeister, P., Haas, C. et al. Neues zu Tumoren der Speicheldrüsen. Pathologie 44, 214–223 (2023). https://doi.org/10.1007/s00292-023-01194-5

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  • DOI: https://doi.org/10.1007/s00292-023-01194-5

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