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Endogenous TGFβ1 Plays a Crucial Role in Functional Recovery After Traumatic Brain Injury Associated with Smad3 Signal in Rats

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An Erratum to this article was published on 25 February 2016

Abstract

Transforming growth factor-β 1 (TGFβ1) has a diverse role in astrogliosis and neuronal survival, but the underlying mechanism remains to be elucidated, especially in traumatic brain injury (TBI). Here, we show that the expression of TGFβ1 was increased in the pericontusional region, accompanied with astrogliosis and neuronal loss in TBI rats. Moreover, TGFβ1 knockdown not only reduced the number of neurons and inhibited astrogliosis but also resulted in a significant neurological dysfunction in rats with TBI. Subsequently, Smad3, a key downstream signal of TGFβ1, was involved in pericontusional region after TBI. These findings therefore indicate that TGFβ1 is involved in neuroprotection and astrogliosis, via activation of down stream Smad3 signal in the brain after injury.

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Acknowledgments

This research was supported by natural science foundation of Yunnan province (No. 2013FB119), and natural science foundation of Zhejiang province (No. Y2090864).

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The authors declare that they have no competing interests.

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    Authors and Affiliations

    1. Department of Neurosurgery, Shanghai Jiao Tong University Affiliated 6th People’s Hospital, Shanghai, 200233, China

      Xu-Yang Wang, Xiao-li Li & Heng-Li Tian

    2. Institute of Neuroscience and Department of Biochemistry, Kunming Medical University, Kunming, 650031, China

      Ying-Chun Ba, Ye-Chun Zhu, Xin-Fu Zhou, Ting-Hua Wang, Fang Wang & Jin-Tao Li

    3. Department of Anesthesiology, Institute of Neurological Disease, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, 610041, China

      Liu-Lin Xiong, Yu Zou & Ting-Hua Wang

    4. Division of Health Sciences, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia

      Xin-Fu Zhou

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    Correspondence to Fang Wang, Heng-Li Tian or Jin-Tao Li.

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    Xu-Yang Wang, Ying-Chun Ba, Fang Wang, Heng-Li Tian and Jin-Tao Li have contributed equally to this work.

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    Wang, XY., Ba, YC., Xiong, LL. et al. Endogenous TGFβ1 Plays a Crucial Role in Functional Recovery After Traumatic Brain Injury Associated with Smad3 Signal in Rats. Neurochem Res 40, 1671–1680 (2015). https://doi.org/10.1007/s11064-015-1634-x

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    • DOI: https://doi.org/10.1007/s11064-015-1634-x

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