Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system
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Cited by (294)
Altered transforming growth factor beta/SMAD3 signalling in patients with hippocampal sclerosis
2018, Epilepsy ResearchCitation Excerpt :TGFβ1 levels were also reported to be altered in the cerebrospinal fluid in DRE patients (Yu et al., 2014). Though the other isoforms TGFβ2 and TGFβ3 are expressed in the dentate gyrus and the CA2 region of hippocampus (Unsicker et al., 1991), their role in epilepsy has not been yet reported. So we focus on the TGFβ1 ligand expression in our study.
Analysis of neurotrophic and antioxidant factors related to midbrain dopamine neuronal loss and brain inflammation in the cerebrospinal fluid of the elderly
2018, Experimental GerontologyCitation Excerpt :Brain inflammation could be exacerbated, at least in part, by trophic factors of the transforming-growth factor family (TGF family), such as TGFβ1 and TGFβ2. These ligands are released by activated microglia, and they are considered as proinflammatory factors (Unsicker et al., 1991; Wyss-Coray et al., 2001; Hirsch and Hunot, 2009; Hirsch et al., 2012). In addition, BDNF is also related to neuroinflammation.
TGF-β1 down-regulation in the mediobasal hypothalamus attenuates hypothalamic inflammation and protects against diet-induced obesity
2018, Metabolism: Clinical and ExperimentalMaternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain
2016, Neurobiology of DiseaseCitation Excerpt :Depletion of TGF-β1 results in a loss of GLT-1 and decreased glutamate uptake in the mouse hippocampus (Koeglsperger et al., 2013). TGF-β1 is expressed by neurons and glial cells (Unsicker et al., 1991) and exerts a protective effect against various neuronal insults (Prehn et al., 1993; Flanders et al., 1998). Most of the research on the role of glial cells in neuroinflammation and glutamate excitotoxicity have focused almost exclusively on adult neurodegeneration and neurological diseases [review (Sidoryk-Wegrzynowicz et al., 2011)].
Immune surveillance of the central nervous system in multiple sclerosis - Relevance for therapy and experimental models
2014, Journal of Neuroimmunology