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Cancer Diagnosis by Terahertz Molecular Imaging Technique

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Abstract

We obtained the diagnostic images of cancerous tumors by employing the THz molecular imaging (TMI) technique which measured the THz response change by surface plasmon resonance induced on the surface of nanoparticles with a irradiation of near-infrared (NIR) beam. To demonstrate the principle of the TMI technique, THz images of tissues with nanoprobes were observed and compared with THz only images. The sensitivity of TMI was further enhanced by adopting a THz differential measurement technique, which was realized by modulating the NIR beams. By employing this differential TMI technique, the diagnostic images of cancerous tumors were obtained ex vivo and in vivo in the preclinical stage. These images indicated the feasibility of applying the differential TMI technique in the clinical stage.

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Acknowledgment

This study was supported by a grant from the Korean Health Technology R&D Project of the Ministry for Health, Welfare & Family Affairs, Republic of Korea (A101954); a National Research Foundation of Korea (NRF) grants funded by the Ministry of Education Science & Technology, Republic of Korea (20100020647, 20100001979, 20100015989, 20100011934, 20090054519); Business for cooperative R&D between industry, academy, and research institute funded Korea small and medium business administration in 2010 (000428380110).

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Authors and Affiliations

  1. Department of Radiology, Medical Convergence Research Institute, Severance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul, 120-752, Republic of Korea

    Seung Jae Oh, Yong-Min Huh & Jin-Suck Suh

  2. Department of Chemical & Biomolecular Engineering, Yonsei University, Seoul, 120-752, Republic of Korea

    Jihye Choi & Seungjoo Haam

  3. Laboratory for Terahertz Biophotonics, Department of Physics, University of Seoul, Seoul, 130-743, Republic of Korea

    Joo-Hiuk Son

Authors
  1. Seung Jae Oh
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  2. Yong-Min Huh
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  3. Jin-Suck Suh
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  4. Jihye Choi
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  5. Seungjoo Haam
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  6. Joo-Hiuk Son
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Corresponding authors

Correspondence to Jin-Suck Suh or Joo-Hiuk Son.

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Oh, S.J., Huh, YM., Suh, JS. et al. Cancer Diagnosis by Terahertz Molecular Imaging Technique. J Infrared Milli Terahz Waves 33, 74–81 (2012). https://doi.org/10.1007/s10762-011-9847-9

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  • DOI: https://doi.org/10.1007/s10762-011-9847-9

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