Abstract
Since ancient times, mushrooms have been a valuable food source and traditional medicine worldwide. Edible mushrooms possess high nutritional value and medicinal significance due to the presence of a large number of active ingredients that cause the development of therapeutic functions. They are used to treat severe diseases like microbial and viral infections, cancer, tumors, inflammation, and cardiovascular and immune diseases. Mushrooms contain various bioactive compounds, including α- and ß-glucans, proteoglycan, lectin, phenolic compounds (flavonoids, flavonoids, phenolic acids), polysaccharides, triterpenoids, steroids, lentinan, schizophyllan, lovastatin, pleuran, glycopeptides, alkaloids, dietary fiber, and others. The biological activities of some well-known edible mushrooms are discussed in this chapter.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Abbreviations
- ABTS:
-
Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)
- AChE:
-
Acetylcholinesterase
- AD:
-
Alzheimer’s disease
- CAT:
-
Catalase
- CDK:
-
Cyclin-dependent kinase
- COX:
-
Cyclooxygenase
- DPP-4:
-
Dipeptidyl peptidase-4
- DPPH:
-
2,2-Diphenyl-1-picrylhydrazyl
- EtOH:
-
Ethanol
- FRAP:
-
Ferric reducing antioxidant power
- GLP:
-
Glucagon-like peptide-1
- GSH:
-
Glutathione
- H2O:
-
Water
- HDL:
-
High-density lipoprotein cholesterol
- IFN-γ:
-
Interferon-γ
- IL:
-
Interleukin
- iNOS:
-
Inducible nitric oxide synthase
- JNK:
-
c-Jun N-terminal kinases
- LDL:
-
Low-density lipoprotein cholesterol
- LPS:
-
Lipopolysaccharide
- MDA:
-
Malondialdehyde
- MMK:
-
Matrix metalloproteinase
- NF-κB:
-
Nuclear factor kappa-light-chain enhancer of activated B cells
- NK:
-
Natural killer
- NLRP3:
-
Nod-like receptor protein 3
- NO:
-
Nitric oxide
- Nrf2:
-
Nuclear factor-E2-related factor 2
- PGE2:
-
Prostaglandin E2
- PSK:
-
Polysaccharide K/Krestin
- PSP:
-
Polysaccharopeptide
- SOD:
-
Superoxide dismutase
- TC:
-
Total cholesterol
- TG:
-
Triglyceride
- TLR4:
-
Toll-like receptor 4
- TNF:
-
Tumor necrosis factor
References
Agbor CA, Fischer CE, Agaba EA et al (2022) Neuroprotective effect of beta-D-glucan polysaccharide on hyperglycaemia-induced cerebral injury in diabetic animal model. Eur J Anat 26(2):217–224. https://doi.org/10.26538/tjnpr/v5i12.24
Al-Dbass AM, Al-Daihan SK, Bhat RS (2012) Agaricus blazei Murill as an efficient hepatoprotective and antioxidant agent against CCl4-induced liver injury in rats. Saudi J Biol Sci 19:303–309. https://doi.org/10.1016/j.sjbs.2012.03.004
Ali MM, Baig MT, Huma A et al (2021) Effect of Agaricus blazei Murill on exploratory behavior of mice-model. Braz Biol 84:e252575. https://doi.org/10.1590/1519-6984.252575
Bach F, Zielinski AAF, Helm CV et al (2019) Bio compounds of edible mushrooms: in vitro antioxidant and antimicrobial activities. Food Sci Technol 107:214–220. https://doi.org/10.1016/j.lwt.2019.03.017
Bao Z, Yao L, Zhang X et al (2020) Isolation, purification, characterization, and immunomodulatory effects of polysaccharide from Auricularia auricula on RAW264.7 macrophages. J Food Biochem 44:e13516. https://doi.org/10.1111/jfbc.13516
Bernardshaw S, Hetland G, Ellertsen LK et al (2005) An extract of the medicinal mushroom Agaricus blazei Murill differentially stimulates production of pro-inflammatory cytokines in human monocytes and human vein endothelial cells in vitro. Inflammation 29:147–153. https://doi.org/10.1007/s10753-006-9010-2
Bovi M, Cenci L, Perduca M et al (2013) BEL-trefoil: a novel lectin with antineoplastic properties in king bolete (Boletus edulis) mushrooms. Glycobiology 23(5):578–592. https://doi.org/10.1093/glycob/cws164
Cao H, Ma S, Guo H et al (2019) Comparative study on the monosaccharide compositions, antioxidant and hypoglycemic activities in vitro of intracellular and extracellular polysaccharides of liquid fermented Coprinus comatus. Int J Biol Macromol 139:543–549. https://doi.org/10.1016/j.ijbiomac.2019.08.017
Carneiro AAJ, Ferreira ICFR, Dueñas M et al (2013) Chemical composition and antioxidant activity of dried powder formulations of Agaricus blazei and Lentinus edodes. Food Chem 138:2168–2173. https://doi.org/10.1016/j.foodchem.2012.12.036
Chang CW, Lur HS, Lu MK et al (2013) Sulfated polysaccharides of Armillaria mellea and their anti-inflammatory activities via NF-κB suppression. Food Res Int 54:239–245. https://doi.org/10.1016/j.foodres.2013.07.005
Chellappan D, Ganasen S, Batumalai S et al (2016) The protective action of the aqueous extract of Auricularia polytricha in paracetamol induced hepatotoxicity in rats. Recent Pat Drug Deliv Formul 10:72–76. https://doi.org/10.2174/1872211309666151030110015
Chen S, Oh SR, Phung S et al (2006) Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus). Cancer Res 66:12026–12034. https://doi.org/10.1158/0008-5472.CAN-06-2206
Chen YJ, Wu SY, Chen CC et al (2014) Armillaria mellea component armillarikin induces apoptosis in human leukemia cells. J Funct Foods 6:196–204. https://doi.org/10.1016/j.jff.2013.10.007
Chen YJ, Chen CC, Huang HL (2016) Induction of apoptosis by Armillaria mellea constituent armillarikin in human hepatocellular carcinoma. OncoTargets Ther 9:4773–4783. https://doi.org/10.2147/OTT.S103940
Chen S, Yong T, Xiao C et al (2018) Pyrrole alkaloids and ergosterols from Grifola frondosa exert anti-α-glucosidase and anti-proliferative activities. J Funct Foods 43:196–205. https://doi.org/10.1016/j.jff.2018.02.007
Chiu WC, Yang HH, Chiang SC et al (2014) Auricularia polytricha aqueous extract supplementation decreases hepatic lipid accumulation and improves antioxidative status in animal model of nonalcoholic fatty liver. Biomedicine 4:29–38. https://doi.org/10.7603/s40681-014-0012-3
Cruz A, Pimentel L, Rodríguez-Alcalá LM et al (2016) Health benefits of edible mushrooms focused on Coriolus versicolor: a review. J Food Nutr Res 4(12):773–781. https://doi.org/10.12691/jfnr-4-12-2
Cui FJ, Li Y, Xu YY et al (2007) Induction of apoptosis in SGC-7901 cells by polysaccharide-peptide GFPS1b from the cultured mycelia of Grifola frondosa GF9801. Toxicol In Vitro 21:417–427. https://doi.org/10.1016/j.tiv.2006.10.004
Ding Z, Lu Y, Lu Z et al (2010) Hypoglycaemic effect of comatin, an anti-diabetic substance separated from Coprinus comatus broth, on alloxan-induced-diabetic rats. Food Chem 121(1):39–43. https://doi.org/10.1016/j.foodchem.2009.12.001
Doğan HH, Akbaş G (2013) Biological activity and fatty acid composition of Caesar’s mushroom. Pharm Biol 51:863–871. https://doi.org/10.3109/13880209.2013.768272
Dotan N, Wasser SP, Mahajna J (2011) The culinary-medicinal mushroom Coprinus comatus as a natural antiandrogenic modulator. Integr Cancer Ther 10(2):148–159. https://doi.org/10.1177/1534735410383169
Dou H, Chang Y, Zhang L (2019) Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China. Prog Mol Biol Transl Sci 163:361–381. https://doi.org/10.1016/bs.pmbts.2019.03.001
Ekowati N, Yuniati NI, Hernayanti H et al (2018) Anti-diabetic potentials of button mushroom (Agaricus bisporus) on Alloxan-induced diabetic rats. Biosaintifika J Biol Biol Edu 10:655–662. https://doi.org/10.15294/biosaintifika.v10i3.17126
Erjavec J, Kos J, Ravnikar M et al (2012) Proteins of higher fungi – from forest to application. Trends Biotechnol 30:259–273. https://doi.org/10.1016/j.tibtech.2012.01.004
Facchini JM, Alves EP, Aguilera C et al (2014) Antitumor activity of Pleurotus ostreatus polysaccharide fractions on Ehrlich tumor and Sarcoma 180. Int J Bio Macromol 68:72–77. https://doi.org/10.1016/j.ijbiomac.2014.04.033
Fang X, Jiang Y, Ji H et al (2015) The synergistic beneficial effects of Ginkgo flavonoid and Coriolus versicolor polysaccharide for memory improvements in a mouse model of dementia. Evid Based Complement Altern Med 128394(9). https://doi.org/10.1155/2014/128394
Friedman M (2016) Mushroom polysaccharides: chemistry and antiobesity, antidiabetes, anticancer, and antibiotic properties in cells, rodents, and humans. Foods 5:80. https://doi.org/10.3390/foods5040080
Fukushima M, Ohashi T, Fujiwara Y et al (2001) Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats. Exp Biol Med 226:758–765. https://doi.org/10.1177/153537020222600808
Gallego P, Luque-Sierra A, Falcon G et al (2021) White button mushroom extracts modulate hepatic fibrosis progression, inflammation, and oxidative stress in vitro and in LDLR−/− mice. Foods 10:1788. https://doi.org/10.3390/foods10081788
Gangarapu V, Yildiz K, İnce AT et al (2014) Role of gut microbiota: obesity and NAFLD. Turk J Gastroenterol 25:133–140. https://doi.org/10.5152/tjg.2014.7886
Gao Z, Kong D, Cai W et al (2021) Characterization and anti-diabetic nephropathic ability of mycelium polysaccharides from Coprinus comatus. Carbohydr Polym 251:117081. https://doi.org/10.1016/j.carbpol.2020.117081
Garcia J, Rodrigues F, Castro F et al (2022) Antimicrobial, Antibiofilm, and antioxidant properties of Boletus edulis and Neoboletus luridiformis against multidrug-resistant ESKAPE pathogens. Front Nutr 8:773346. https://doi.org/10.3389/fnut.2021.773346
Gashaw G, Fassil A, Redi F (2020) Evaluation of the antibacterial activity of Pleurotus spp. cultivated on different agricultural wastes in Chiro, Ethiopia. Int J Microbiol. https://doi.org/10.1155/2020/9312489
Geng Y, Zhu S, Cheng P et al (2017) Bioassay-guided fractionation of ethyl acetate extract from Armillaria mellea attenuates inflammatory response in lipopolysaccharide (LPS) stimulated BV-2 microglia. Phytomedicine 26:55–61. https://doi.org/10.1016/j.phymed.2017.01.005
Gobi VV, Rajasankar S, Johnson VMS et al (2019) Anti-apoptotic role of Agaricus blazei extract in rodent model of Parkinson’s disease. Front Biosci 11:12–19. https://doi.org/10.2741/E842
Golak-Siwulska I, Kałużewicz A, Spiżewski T et al (2018a) Bioactive compounds and medicinal properties of Oyster mushrooms (sp.). Folia Hortic 30(2):191–201. https://doi.org/10.2478/fhort-2018-0012
Golak-Siwulska I, Kałuzewicz A, Wdowienko S et al (2018b) Nutritional value and health-promoting properties of Agaricus bisporus (Lange) Imbach. Herba Pol 64:71–81. https://doi.org/10.2478/hepo-2018-0027
Gu Y-H, Sivam G (2006) Cytotoxic effect of oyster mushroom Pleurotus ostreatus on human androgen independent prostate cancer PC-3 cells. J Med Food 9:196–204. https://doi.org/10.1089/jmf.2006.9.196
Guo Y, Deng G, Xu X et al (2012) Antioxidant capacities, phenolic compounds and polysaccharide contents of 49 edible macro-fungi. Food Funct 3(11):1195. https://doi.org/10.1039/C2FO30110E
Guo L, Qian X, Dai H et al (2020a) Antioxidant and antibacterial properties of extracts from different polar solvents from Boletus edulis Bull. Food Sci Technol Int 45(04):175–181
Guo WL, Deng JC, Pan YY et al (2020b) Hypoglycemic and hypolipidemic activities of Grifola frondosa polysaccharides and their relationships with the modulation of intestinal microflora in diabetic mice induced by high-fat diet and streptozotocin. Int J Biol Macromol 153:1231–1240. https://doi.org/10.1016/j.ijbiomac.2019.10.253
Habtemariam S (2020) Trametes versicolor (Synn. Coriolus versicolor) polysaccharides in cancer therapy: targets and efficacy. Biomedicine 8(5). https://doi.org/10.3390/biomedicines8050135
Harada N, Kodama N, Nanba H (2003) Relationship between dendritic cells and the D-fraction-induced Th-1 dominant response in BALB/c tumor-bearing mice. Cancer Lett 192:181–187. https://doi.org/10.1016/S0304-3835(02)00716-4
He X, Wang X, Fang J et al (2017) Polysaccharides in Grifola frondosa mushroom and their health promoting properties: a review. Int J Biol Macromol 101:910–921. https://doi.org/10.1016/j.ijbiomac.2017.03.177
Heleno SA, Ferreira RC, Antonio AL et al (2015) Nutritional value, bioactive compounds and antioxidant properties of three edible mushrooms from Poland. Food Biosci 11:48–55. https://doi.org/10.1016/j.fbio.2015.04.006
Hobbs C (2005) Medicinal value of Turkey tail fungus Trametes versicolor (L.: Fr.) Pilát (Aphyllophoromycetideae). Int J Med Mushrooms 7(3):346–347. https://doi.org/10.1615/IntJMedMushr.v6.i3.100
Hossen SM, Tanim MAH, Hossain MS et al (2021) Deciphering the CNS anti-depressant, antioxidant and cytotoxic profiling of methanol and aqueous extracts of Trametes versicolor and molecular interactions of its phenolic compounds. Saudi J Biol Sci 28(11):6375–6383. https://doi.org/10.1016/j.sjbs.2021.07.016
Hsu CH, Liao YL, Lin SC et al (2007) The mushroom Agaricus brasiliensis in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blind and placebo-controlled clinical trial. J Altern Complement Med 13:97–102. https://doi.org/10.1089/acm.2006.6054
Hu Q, Yu J, Yang W et al (2016) Identification of flavonoids from Flammulina velutipes and its neuroprotective effect on pheochromocytoma-12 cells. Food Chem 204:274–282. https://doi.org/10.1016/j.foodchem.2016.02.138
Hu XY, Liu CG, Wang X et al (2017) Hyperglycemic and antidiabetic nephritis activities of polysaccharides separated from Auricularia auricular in diet-streptozotocin-induced diabetic rats. Exp Ther Med 13:352–358. https://doi.org/10.3892/etm.2016.3943
Hu W, Li Z, Wang W et al (2021) Structural characterization of polysaccharide purified from Amanita caesarea and its pharmacological basis for application in Alzheimer’s disease: endoplasmic reticulum stress. Food Funct 12:11009. https://doi.org/10.1039/d1fo01963e
Husen F, Hernayanti H, Ekowati N et al (2021) Antidiabetic effects and antioxidant properties of the saggy ink cap medicinal mushroom, Coprinus comatus (Agaricomycetes), in streptozotocin-induced hyperglycemic rats. Int J Med Mushrooms 23(10):9–21. https://doi.org/10.1615/IntJMedMushrooms.2021040020
Inoue A, Kodama N, Nanba H (2002) Effect of Maitake (Grifola frondosa) D-fraction on the control of the T lymph node Th-1/Th-2 proportion. Biol Pharm Bull 25:536–540. https://doi.org/10.1248/bpb.25.536
Ito H, Shimura K, Itoh H et al (1997) Antitumor effects of a new polysaccharide protein complex (ATOM) prepared from Agaricus blazei (Iwade strain 101) “Himematsutake” and its mechanism in tumor-bearing mice. Anticancer Res 17:277–284
Iwalokun BA, Usen UA, Otunba AA et al (2007) Comparative phytochemical evaluation, antimicrobial and antioxidant properties of Pleurotus ostreatus. Afr J Biotechnol 6(15):1732–1739
Janjusević L, Karaman M, Sibul F et al (2017) The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents. J Enzyme Inhibit Med Chem 32(1):355–362. https://doi.org/10.1080/14756366.2016.1252759
Janjusevic L, Pejin B, Kaisarevic S et al (2018) Trametes versicolor ethanol extract, a promising candidate for health–promoting food supplement. Nat Prod Res 32(8):963–967. https://doi.org/10.1080/14786419.2017.1366484
Jayakumar T, Thomas PA, Geraldine P (2007) Protective effect of an extract of the oyster mushroom, Pleurotus ostreatus, on antioxidants of major organs of aged rats. Exp Gerontol 42:183–191. https://doi.org/10.1016/j.exger.2006.10.006
Jayakumar T, Thomas PA, Sheu JR et al (2011) In-vitro and in-vivo antioxidant effects of the oyster mushrooms P. ostreatus. Food Res Int 44:851–861. https://doi.org/10.1016/j.foodres.2011.03.015
Jedinak A, Sliva D (2008) Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent pathway. Int J Oncol 33:1307–1313. https://doi.org/10.3892/ijo_00000122
Jedinak A, Dudhgaonkar S, Jiang J et al (2010) Pleurotus ostreatus inhibits colitis related colon carcinogenesis in mice. Int J Mol Med 26:643–650. https://doi.org/10.3892/ijmm_00000509
Jeong SC, Jeong YT, Yang BK et al (2010) White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutr Res 30:49–56. https://doi.org/10.1016/j.nutres.2009.12.003
Jeong SC, Koyyalamudi SR, Jeong YT et al (2012) Macrophage immunomodulating and anti-tumor activities of polysaccharides isolated from Agaricus bisporus white button mushrooms. J Med Food 15:58–65. https://doi.org/10.1089/jmf.2011.1704
Ji H, Huang H, Chao J et al (2014) Protective effect of Agaricus brasiliensis on STZ-induced diabetic neuropathic pain in rats. Evid Based Complement Alternat Med 2014:1. https://doi.org/10.1155/2014/679259
Jiang T, Shen S, Wang L et al (2020) Grifola frondosa polysaccharide ameliorates early diabetic nephropathy by suppressing the TLR4/NF-κB pathway. Appl Biochem Biotechnol 194:4093. https://doi.org/10.1007/s12010-022-03976-8
Jin C, Choi YH, Moon D et al (2006) Induction of G2/Marrest and apoptosis in human gastric epithelial AGS cells by aqueous extract of Agaricus blazei. Oncol Rep 16:1349–1355. https://doi.org/10.3892/or.16.6.1349
Jo WS, Kang MJ, Choi SY et al (2010) Culture conditions for mycelial growth of Coriolus versicolor. Mycobiology 38:195–202. https://doi.org/10.4489/MYCO.2010.38.3.195
Johnson E, Forland DT, Saetre L et al (2009) Effect of an extract based on the medicinal mushroom Agaricus blazei Murill on release of cytokines, chemokines and leukocyte growth factors in human blood ex vivo and in vivo. Scand J Immunol 69:242–250. https://doi.org/10.1111/j.1365-3083.2008.02218.x
Kang MA, Jeon YK, Nam MJ (2020) Auricularia auricula increases an apoptosis in human hepatocellular carcinoma cells via a regulation of the peroxiredoxin1. J Food Biochem 44:e13373. https://doi.org/10.1111/jfbc.13373
Karasoy AF, Okuyucu H, Pekşen A (2019) Flammulina velutipes mantarı. J Fungus 10:152–162
Kim SK, Im J, Yun CH et al (2008) Armillaria mellea induces maturation of human dendritic cells without induction of cytokine expression. J Ethnopharmacol 119:153–159. https://doi.org/10.1016/j.jep.2008.06.032
Kim MO, Moon DO, Jung JM et al (2011) Agaricus blazei extract induces apoptosis through ROS-dependent JNK activation involving the mitochondrial pathway and suppression of constitutive NF-κB in THP-1 cells. Evid Based Complement Alternat Med. https://doi.org/10.1093/ecam/nep176
Kodama N, Harada N, Nanba H (2002) A polysaccharide extract from Grifola frondosa, induces Th-1 dominant responses in carcinoma-bearing BALB/cmice. Jpn J Pharmacol 90:357–360. https://doi.org/10.1254/jjp.90.357
Kodama N, Murata Y, Nanba H (2004) Administration of a polysaccharide from Grifola frondosa stimulates immune function of normal mice. J Med Food 7:141–145. https://doi.org/10.1089/1096620041224012
König S, Romp E, Krauth V et al (2019) Melleolides from honey mushroom inhibit 5-lipoxygenase via Cys159. Cell Chem Biol 26:60–70. https://doi.org/10.1016/j.chembiol.2018.10.010
Kozarski M, Klaus A, Nikšić M et al (2012) Antioxidative activities and chemical characterization of polysaccharide extracts from the widely used mushrooms Ganoderma applanatum, Ganoderma lucidum, Lentinus edodes and Trametes versicolor. J Food Compost Anal 26(1–2):144–153. https://doi.org/10.1016/j.jfca.2012.02.004
Kubo K, Nanba H (1997) Anti-hyperliposis effect of Maitake fruit body (Grifola frondosa). Biol Pharm Bull 20:781–785. https://doi.org/10.1248/bpb.20.781
Lemieszek MK, Cardoso C, Nunes FHFM et al (2013) Boletus edulis biological active biopolymers induce cell cycle arrest in human colon adenocarcinoma cells. Food Funct 4:575–585. https://doi.org/10.1039/C2FO30324H
Lemieszek MK, Ribeiro M, Alves HG et al (2016) Boletus edulis ribonucleic acid–a potent apoptosis inducer in human colon adenocarcinoma cells. Food Funct 7:3163–3175. https://doi.org/10.1039/C6FO00132G
Leung MYK, Fung KP, Choy YM (1997) The isolation and characterization of an immunomodulatory and anti-tumor polysaccharide preparation from Flammulina velutipes. Int Immunopharmacol 35:255–263. https://doi.org/10.1016/S0162-3109(96)00157-9
Li Z, Wang Y, Jiang B et al (2016) Structure, cytotoxic activity and mechanism of protoilludane sesquiterpene aryl esters from the mycelium of Armillaria mellea. J Ethnopharmacol 184:119–127. https://doi.org/10.1016/j.jep.2016.02.044
Li Z, Chen X, Zhang Y et al (2019) Protective roles of Amanita caesarea polysaccharides against Alzheimer’s disease via Nrf2 pathway. Int J Biol Macromol 121:29–37. https://doi.org/10.1016/j.ijbiomac.2018.09.216
Li W, Wang Y, Sun M et al (2020a) The prebiotic-like effects of Coprinus comatus polysaccharides on gut microbiota in normal mice and those with acute alcoholic liver injury: a comparative study. Evid Based Complement Altern. https://doi.org/10.1155/2020/2027570
Li Y, Sheng Y, Lu X et al (2020b) Isolation and purification of acidic polysaccharides from Agaricus blazei Murill and evaluation of their lipid lowering mechanism. Int J Biol Macromol 157:276–287. https://doi.org/10.1016/j.ijbiomac.2020.04.190
Lima CUJO, Cordova COA, Nobrega OT et al (2011) Does the Agaricus blazei Murill mushroom have properties that affect the immune system? An integrative review. J Med Food 14:2–8. https://doi.org/10.1089/jmf.2010.0017
Liu J, Jia L, Kan J et al (2013) In vitro and in vivo antioxidant activity of ethanolic extract of white button mushroom (Agaricus bisporus). Food Chem Toxicol 51:310–316. https://doi.org/10.1016/j.fct.2012.10.014
Liu L, Li M, Yu M et al (2019) Natural polysaccharides exhibit anti-tumor activity by targeting gut microbiota. Int J Biol Macromol 121:743–751. https://doi.org/10.1016/j.ijbiomac.2018.10.083
Liu Q, Ma S, Li S et al (2022) Dietary supplementation of Auricularia auricula-judae polysaccharides alleviate nutritional obesity in mice via regulating inflammatory response and lipid metabolism. Foods 11:942. https://doi.org/10.3390/foods11070942
Luo A, Luo A, Huang J et al (2012) Purification, characterization, and antioxidant activities in vitro and in vivo of the polysaccharides from Boletus edulis Bull. Molecules 17(7):8079–8090. https://doi.org/10.3390/molecules17078079
Ma X, Zhou F, Chen Y et al (2014) A polysaccharide from Grifola frondosa relieves insulin resistance of HepG2 cell by Akt-GSK-3pathway. Glycoconj J 31:355–363. https://doi.org/10.1007/s10719-014-9526-x
Mapoung S, Umsumarng S, Semmarath W et al (2021) Skin wound-healing potential of polysaccharides from medicinal mushroom Auricularia auricula-judae (Bull.). J Fungi 7:247
Masuda Y, Inoue M, Miyata A et al (2009a) Maitake β-glucan enhances therapeutic effect and reduces myelosupression and nephrotoxicity of cisplatin in mice. Int Immunopharmacol 9:620–626. https://doi.org/10.1016/j.intimp.2009.02.005
Masuda Y, Matsumoto A, Toida T et al (2009b) Characterization and antitumor effect of a novel polysaccharide from Grifola frondosa. J Agric Food Chem 57:10143–10149. https://doi.org/10.1021/jf9021338
Matsushita Y, Furutani Y, Matsuoka R et al (2018) Hot water extract of Agaricus blazei Murrill specifically inhibits growth and induces apoptosis in human pancreatic cancer cells. BMC Complement Alternat Med 18:319. https://doi.org/10.1186/s12906-018-2385-4
Mayell M (2001) Maitake extracts and their therapeutic potential. Altern Med Rev 6:48–60
Meng Y, Yan J, Yang G et al (2018) Structural characterization and macrophage activation of a hetero-galactan isolated from Flammulina velutipes. Carbohydr Polym 183:207–218. https://doi.org/10.1016/j.carbpol.2017.12.017
Meng T, Yu S, Ji H et al (2021) A novel acid polysaccharide from Boletus edulis: extraction, characteristics, and antitumor activities in vitro. Glycoconj J 38:13–24. https://doi.org/10.1007/s10719-021-09972-0
Mitra P, Khatua S, Acharya K (2013) Free radical scavenging and NOS activation properties of water soluble crude polysaccharides from Pleurotus ostreatus. Asian J Pharm Clin Res 6(3):67–70
Nowakowski P, Markiewicz-Zukowska R, Gromkowska-Kępka K et al (2021) Mushrooms as potential therapeutic agents in the treatment of cancer: evaluation of anti-glioma effects of Coprinus comatus, Cantharellus cibarius, Lycoperdon perlatum and Lactarius deliciosus extracts. Biomed Pharmacother 133:111090. https://doi.org/10.1016/j.biopha.2020.111090
Oli AN, Edeh PA, Al-Mosawi RM et al (2020) Evaluation of the phytoconstituents of Auricularia auricula-judae mushroom and antimicrobial activity of its protein extract. Eur J Integr Med 38:101176. https://doi.org/10.1016/j.eujim.2020.101176
Park KH, Lee ES, Jin YI et al (2016) Inhibitory effect of Panax ginseng and Pleurotus ostreatus complex on expression of cytokine genes induced by extract of Dermatophagoides pteronyssinus in human monocytic THP-1 and EoL-1 cells. J Mushroom Sci Prod 14(4):155–161. https://doi.org/10.14480/JM.2016.14.4.155
Park HJ, Yun J, Jang S-H et al (2020) Coprinus comatus cap inhibits adipocyte differentiation via regulation of PPARc and Akt signaling pathway. PLoS One 9(9):e105809. https://doi.org/10.1371/journal.pone.0105809
Patel Y, Naraian R, Singh VK (2012) Medicinal properties of Pleurotus species (oyster mushroom): a review. WJFPB 3(1):1–12. https://doi.org/10.5829/idosi.wjfpb.2012.3.1.303
Perera N, Yang FH, Chiu HW et al (2020) Phagocytosis enhancement, endotoxin tolerance, and signal mechanisms of immunologically active glucuronoxylomannan from Auricularia auricula-judae. Int J Biol Macromol 165:495–505. https://doi.org/10.1016/j.ijbiomac.2020.09.171
Piska K, Sułkowska-Ziaja K, Muszyńska B (2017) Edible mushroom Pleurotus ostreatus (oyster mushroom): its dietary significance and biological activity. Acta Sci Pol 16(1)
Preuss HG, Echard B, Bagchi D et al (2010) Maitake mushroom extracts ameliorate progressive hypertension and other chronic metabolic perturbations in aging female rats. Int J Med Sci 7:169. https://doi.org/10.7150/ijms.7.169
Raseta M, Popović M, Knezevic P et al (2020) Bioactive phenolic compounds of two medicinal mushroom species Trametes versicolor and Stereum subtomentosum as antioxidant and antiproliferative agents. Chem Biodivers 17(12):e2000683. https://doi.org/10.1002/cbdv.202000683
Ratnaningtyas NI, Hernayanti EN, Sukmawati D et al (2019) Chicken drumstick mushroom (Coprinus comatus) ethanol extract exerts a hypoglycaemic effect in the Rattus norvegicus model of diabetes. Biocatal Agric Biotechnol 19:1–9. https://doi.org/10.1016/j.bcab.2019.101050
Ratnaningtyas NI, Hernayanti EN, Ekowati N et al (2022) Ethanol extract of the mushroom Coprinus comatus exhibits antidiabetic and antioxidant activities in streptozotocin-induced diabetic rats. Pharm Biol 60:1126–1113. https://doi.org/10.1080/13880209.2022.2074054
Reis FS, Martins A, Barros L et al (2012) Antioxidant properties and phenolic profile of the most widely appreciated cultivated mushrooms: a comparative study between in vivo and in vitro. Food Chem Toxicol 50:1201–1207. https://doi.org/10.1016/j.fct.2012.02.013
Rouhana-Toubi A, Wasser SP, Fares F (2015) The shaggy ink cap medicinal mushroom, Coprinus comatus (higher basidiomycetes) extract induces apoptosis in ovarian cancer cells via extrinsic and intrinsic apoptotic pathways. Int J Med Mushrooms 17:1127–1136. https://doi.org/10.1615/intjmedmushrooms.v17.i12.20
Shen KP, Su CH, Lu TM et al (2015) Effects of Grifola frondosa non-polar bioactive components on high-fat diet fed and streptozotocin-induced hyperglycemic mice. Pharm Biol 53:705–709. https://doi.org/10.3109/13880209.2014.939290
Sihoglu Tepe A (2021) Chemical compositions and antioxidant activities of four different mushroom species collected from Turkey. Int J Second Metab 8:214–226. https://doi.org/10.21448/ijsm.953923
Smiderle FR, Alquini G, Tadra-Sfeir MZ et al (2013) Agaricus bisporus and Agaricus brasiliensis (1→6)-β-d-glucans show immunostimulatory activity on human THP-1 derived macrophages. Carbohydr Polym 94:91–99. https://doi.org/10.1016/j.carbpol.2012.12.073
Song HH, Chae HS, Oh SR et al (2012) Anti-inflammatory and antiallergic effect of Agaricus blazei extract in bone marrow-derived mast cells. Am J Chin Med 40:1073–1084. https://doi.org/10.1142/S0192415X12500796
Stilinović N, Čapo I, Vukmirović S et al (2020) Chemical composition, nutritional profile and in vivo antioxidant properties of the cultivated mushroom Coprinus comatus. R Soc Open Sci 7:200900. https://doi.org/10.1098/rsos.200900
Su CH, Lu TM, Lai MN et al (2013) Inhibitory potential of Grifola frondosa bioactive fractions on α-amylase and α-glucosidase for management of hyperglycemia. Biotechnol Appl Biochem 60:446–452. https://doi.org/10.1002/bab.1105
Su A, Yang W, Zhao L et al (2018) Flammulina velutipes polysaccharides improve scopolamine-induced learning and memory impairment in mice by modulating gut microbiota composition. Food Funct 9:1424–1432. https://doi.org/10.1039/C7FO01991B
Sun C, Rosendahl AH, Wang XD et al (2012) Polysaccharide-K (PSK) in cancer - old story, new possibilities? Curr Med Chem 19(5):757–762. https://doi.org/10.2174/092986712798992020
Sun X, Zhang T, Zhao Y et al (2020) Protoilludane sesquiterpenoid aromatic esters from Armillaria mellea improve depressive-like behavior induced by chronic unpredictable mild stress in mice. J Funct Food 66:103799. https://doi.org/10.1016/j.jff.2020.103799
Tangen JM, Tierens A, Caers J et al (2015) Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomized, double blinded clinical study. Biomed Res Int 2015:718539. https://doi.org/10.1155/2015/718539
Therkelsen SP, Hetland G, Lyberg T et al (2016) Cytokine levels after consumption of a medicinal Agaricus blazei Murill-based mushroom extract, AndoSanTM, in patients with Crohn’s disease and ulcerative colitis in a randomized single-blinded placebo controlled study. Scand J Immunol 84:323–331. https://doi.org/10.1111/sji.12476
Valenti MT, Marchetto G, Perduca M et al (2020) BEL β-trefoil reduces the migration ability of RUNX2 expressing melanoma cells in xenotransplanted zebrafish. Molecules 25:1270. https://doi.org/10.3390/molecules25061270
Venkatakrishnan V, Shenbhagaraman R, Kaviyarasan V et al (2010) Antioxidant and antiproliferative effect of Pleurotus ostreatus. J Phytology 2(1):22–28
Vitak TY, Wasser SP, Nevo E et al (2015) The effect of the medicinal mushrooms Agaricus brasiliensis and Ganoderma lucidum (higher basidiomycetes) on the erythron system in normal and streptozotocin-induced diabetic rats. Int J Med Mushrooms 17:277–286. https://doi.org/10.1615/IntJMedMushrooms.v17.i3.70
Volman JJ, Helsper JPFG, Wei S et al (2009) Effects of mushroom derived beta-glucan-rich polysaccharide extracts on NO production by bone marrow-derived macrophages and NF-kappaB transactivation in Caco-2 reporter cells: can effects be explained by structure? Mol Nutr Food Res 54:268–276. https://doi.org/10.1002/mnfr.200900009
Wan JM-F (2013) Polysaccharide krestin (PSK) and polysaccharopeptide PSP. In: Kastin AJ (ed) Handbook of biologically active peptides, vol 27. Elsevier, New York, pp 180–184. https://doi.org/10.1016/B978-0-12-385095-9.00027-0
Wang H, Ng TB (2000) Isolation of a novel ubiquitin-like protein from Pleurotus ostreatus mushroom with ant-human immunodeficiency virus, translation inhibitory and ribonuclease activities. Biochem Biophys Res Commun 276:587–593. https://doi.org/10.1006/bbrc.2000.3540
Wang C, Ju L, Liu M et al (2007) Effects of Auricularia auricula polysaccharide on the expression of MMP-13 in rabbit arteriosclerosis plaque. Chin Rem Clin 14:161–168. https://doi.org/10.1021/acs.jafc.0c05934
Wang CL, Meng M, Liu SB et al (2013a) A chemically sulfated polysaccharide from Grifola frondosa induces HepG2 cell apoptosis by notch1-NF-κB pathway. Carbohydr Polym 95:282–287. https://doi.org/10.1016/j.carbpol.2013.02.057
Wang P, Li XT, Sun L et al (2013b) Anti-inflammatory activity of water-soluble polysaccharide of Agaricus blazei Murill on ovariectomized osteopenic rats. Evid Based Complement Alternat Med 2013:164817. https://doi.org/10.1155/2013/164817
Wang Y, Fang J, Ni X et al (2013c) Inducement of cytokine release by GFPBW2, a novel polysaccharide from fruit bodies of Grifola frondosa, through dectin-1 in macrophages. J Agric Food Chem 61:11400–11409. https://doi.org/10.1021/jf4029915
Wang D, Sun SQ, Wu WZ et al (2014a) Characterization of a water-soluble polysaccharide from Boletus edulis and its antitumor and immunomodulatory activities on renal cancer in mice. Carbohydr Polym 105:127–134. https://doi.org/10.1016/j.carbpol.2013.12.085
Wang Y, Shen X, Liao W et al (2014b) A heteropolysaccharide, L-fuco-D-manno-1, 6-α-D-galactan extracted from Grifola frondosa and antiangiogenic activity of its sulfated derivative. Carbohydr Polym 101:631–641. https://doi.org/10.1016/j.carbpol.2013.09.085
Wang J, Hu S, Nie S et al (2016) Reviews on mechanisms of in vitro antioxidant activity of polysaccharides. Oxid Med Cell Longev 2016:5692852. https://doi.org/10.1155/2016/5692852
Wei Q, Zhan Y, Chen B et al (2020) Assessment of antioxidant and antidiabetic properties of Agaricus blazei Murill extracts. Food Sci Nutr 8:332–339. https://doi.org/10.1002/fsn3.1310
Wiater A, Paduch R, Pleszczyńska M et al (2011) α-(1→3)-D-glucans from fruiting bodies of selected macromycetes fungi and the biological activity of their carboxymethylated products. Biotechnol Lett 33:787–795. https://doi.org/10.1007/s10529-010-0502-7
Wu SJ, Tsai JY, Lai MN et al (2007) Armillaria mellea shows antiinflammatory activity by inhibiting the expression of NO, iNOS, COX-2 and cytokines in THP-1 cells. Am J Chin Med 35:507–516. https://doi.org/10.1142/S0192415X07005028
Wu Q, Tan ZP, Liu HD et al (2010) Chemical characterization of Auricularia auricula polysaccharides and its pharmacological effect on heart antioxidant enzyme activities and left ventricular function in aged mice. Int J Biol Macromol 46:284–288. https://doi.org/10.1016/j.ijbiomac.2010.01.016
Wu J-Y, Chen C-H, Chang W-H et al (2011) Anti-cancer effects of protein extracts from Calvatia lilacina, Pleurotus ostreatus and Volvariella volvacea. Evid Based Complement Altern Med. https://doi.org/10.1093/ecam/neq057
Wu S, Wang G, Yang R et al (2016) Anti-inflammatory effects of Boletus edulis polysaccharide on asthma pathology. Am J Transl Res 8(10):4478–4489
Wu JY, Siu KC, Geng P (2021) Bioactive ingredients and medicinal values of Grifola frondosa (Maitake). Foods 10:95. https://doi.org/10.3390/foods10010095
Xiao C, Wu Q, Xie Y et al (2015) Hypoglycemic effects of Grifola frondosa (Maitake) polysaccharides F2 and F3 through improvement of insulin resistance in diabetic rats. Food Funct 6:3567–3575. https://doi.org/10.1039/C5FO00497G
Xiao Y, Xu Q, Zhou X et al (2018) The improvement effect of Boletus edulis polysaccharides on the liver injury in type 2 diabetic rats. Food Sci Technol 39(11):297–313
Xu H, Yang YJ, Yang T et al (2013) Statins and stem cell modulation. Ageing Res Rev 12:1–7. https://doi.org/10.1016/j.arr.2012.03.006
Xu Y, Zhang Z, Wang B et al (2022) Flammulina velutipes polysaccharides modulate gut microbiota and alleviate carbon tetrachloride-induced hepatic oxidative injury in mice. Front Microbiol 13:847653. https://doi.org/10.3389/fmicb.2022.847653
Yamaç M, Kanbak G, Zeytinoğlu M et al (2010) Pancreas protective effect of button mushroom Agaricus bisporus (J.E. Lange) Imbach (Agaricomycetidae) extract on rats with Streptozotocin-induced diabetes. Int J Med Mushrooms 12(4):379–389. https://doi.org/10.1615/IntJMedMushr.v12.i4.50
Yang S, Meng Y, Yan J et al (2019) Polysaccharide-enriched fraction from Armillaria mellea fruiting body improves insulin resistance. Molecules 24:46. https://doi.org/10.3390/molecules24010046
Ye J, Wang X, Wang K et al (2020) A novel polysaccharide isolated from Flammulina velutipes, characterization, macrophage immunomodulatory activities and its impact on gut microbiota in rats. J Anim Physiol Anim Nutr (Berl) 104:735–748. https://doi.org/10.1111/jpn.13290
Yin H, Wang Y, Wang T et al (2010) Purification, characterization and immuno-modulating properties of polysaccharides isolated from Flammulina velutipes mycelium. Am J Chin Med 38:191–204. https://doi.org/10.1142/S0192415X10007750
Yu CH, Kan SF, Shu CH et al (2009) Inhibitory mechanisms of Agaricus blazei Murill on the growth of prostate cancer in vitro and in vivo. J Nutr Biochem 20:753–764. https://doi.org/10.1016/j.jnutbio.2008.07.004
Yu J, Sun RL, Zhao ZQ et al (2014) Auricularia polytricha polysaccharides induce cell cycle arrest and apoptosis in human lung cancer A549 cells. Int J Biol Macromol 68:67–71. https://doi.org/10.1016/j.ijbiomac.2014.04.018
Zavastin DE, Mircea C, Aprotosoaie AC et al (2015) Armillaria mellea: phenolic content, in vitro antioxidant and antihyperglycemic effects. Rev Med Chir Soc Med Nat Iasi 119(1):273–280. https://doi.org/10.3390/ijms12106367
Zeng WC, Zhang Z, Gao H et al (2012) Characterization of antioxidant polysaccharides from Auricularia auricular using microwave-assisted extraction. Carbohydr Polym 89:694–700. https://doi.org/10.1016/j.carbpol.2012.03.078
Zeng F, Zhao C, Pang J et al (2013) Chemical properties of a polysaccharide purified from solid-state fermentation of Auricularia auricular and its biological activity as a hypolipidemic agent. J Food Sci 78:H1470–H1475. https://doi.org/10.1111/1750-3841.12226
Zhang Y, Dai L, Kong X et al (2012) Characterization and in vitro antioxidant activities of polysaccharides from Pleurotus ostreatus. Int J Biol Macromol 51(3):259–265. https://doi.org/10.1016/j.ijbiomac.2012.05.003
Zhang Y, Li H, Yang X et al (2018) Cognitive-enhancing effect of polysaccharides from Flammulina velutipes on Alzheimer’s disease by compatibilizing with ginsenosides. Int J Biol Macromol 112:788–795. https://doi.org/10.1016/j.ijbiomac.2017.12.149
Zhang Y, Zhou R, Liu F et al (2021) Purification and characterization of a novel protein with activity against non-small-cell lung cancer in vitro and in vivo from the edible mushroom Boletus edulis. Int J Biol Macromol 174:77–88. https://doi.org/10.1016/j.ijbiomac.2021.01.149
Zhao R, Ji Y, Chen X et al (2020) Effects of a β-type glycosidic polysaccharide from Flammulina velutipes on anti-inflammation and gut microbiota modulation in colitis mice. Food Funct 11:4259–4274. https://doi.org/10.1039/C9FO03017D
Zheng Q, Zhang H, Li W et al (2019) Hepatoprotective effect of Boletus edulis polysaccharides on mice with acute hepatic damage. Food Mach 35(12):141–145
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Şöhretoğlu, D., Kuruüzüm-Uz, A. (2023). Biological Activities of Some Edible Mushrooms. In: Agrawal, D.C., Dhanasekaran, M. (eds) Mushrooms with Therapeutic Potentials. Springer, Singapore. https://doi.org/10.1007/978-981-19-9550-7_14
Download citation
DOI: https://doi.org/10.1007/978-981-19-9550-7_14
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-19-9549-1
Online ISBN: 978-981-19-9550-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)