Abstract
The etiology of cancer is profoundly associated with variable degrees of oxidative stress in a tissue. Mitochondria, being the paramount seat of oxidative stress generation in a cell, are actively involved in regulating the physiological facets of cancer cells. These organelles maintain a redox imbalance-derived homeostasis in neoplastic cells, which is conducive for the initiation of tumors as well as for cancer progression. Mitochondria achieve such redox imbalance in tumors by inducing oxidative stress only to a certain level, beyond which further stress can kill the cancer cells intrinsically. This chapter is aimed at elucidating the complexities of the mitochondrial paraphernalia in the etiology of cancer. This includes the tumor-associated mitochondrial alterations, such as generation of excessive oxidative stress, mitochondrial antioxidants, mitochondria-governed metabolic adaptations in the tumor microenvironment, oxidative injury to mitochondrial DNA, resistance to apoptosis, and predilection for autophagy. The chapter also explores the role of mitochondrial oxidative stress in tumor growth and metastasis. Moreover, the chapter examines a variety of mitochondrial markers for different types of cancer. A number of mitochondria-targeted cancer therapy approaches have also been reviewed in this chapter.
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Guha, G., Bhakta-Guha, D. (2021). Oxidative Dyshomeostasis in the Mitochondria. In: Chakraborti, S., Ray, B.K., Roychowdhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-4501-6_70-1
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