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Griseofulvin

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Mechanism of Action of Antimicrobial and Antitumor Agents

Part of the book series: Antibiotics ((ANTIBIOTICS,volume 3))

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Abstract

In 1946, Brian, Curtis and Hemming isolated a substance from cultures of Penicillium janczewskii Zal which caused abnormal curling of fungal hyphae. This material was later shown to be identical to griseofulvin (Grove and McGowan, 1947; Brian et al., 1949). The latter compund was first isolated in 1939 by Oxford, Raistrick and Simonart. The structure of griseofulvin, as proposed by Grove et al. (1952) is shown in Fig. 1.

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Authors
  1. Floyd M. Huber
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Editors and Affiliations

  1. Department of Biochemistry, The Medical and Dental Schools, Northwestern University, 303 E. Chicago Avenue, Chicago, Illinois, 60611, USA

    John W. Corcoran Ph.D.

  2. Department of the Army, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C., 20012, USA

    Fred E. Hahn Ph.D.

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© 1975 Springer-Verlag Berlin Heidelberg

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Huber, F.M. (1975). Griseofulvin. In: Corcoran, J.W., Hahn, F.E., Snell, J.F., Arora, K.L. (eds) Mechanism of Action of Antimicrobial and Antitumor Agents. Antibiotics, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46304-4_41

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  • DOI: https://doi.org/10.1007/978-3-642-46304-4_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46306-8

  • Online ISBN: 978-3-642-46304-4

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