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Evidence for the Involvement of Genetic Differences and Mesenchymal Factors in the Progression of Oncogene-Induced Prostate Cancer in Reconstituted Mouse Prostate

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Molecular and Cellular Biology of Prostate Cancer

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Abstract

Carcinogenesis is a multi-step process involving the accumulation of alterations within the cellular genome (reviewed in 1,2). These alterations can occur in protooncogenes converting them into activated oncogenes, and it has been suggested that the multi-step nature of carcinogenesis may partly reflect the consecutive activation of several dominantly acting oncogenes (3-7). It seems reasonable to presume that prostatic cancer follows this pattern. In support of this notion, oncogene activities have been reported to be present in human prostatic adenocarcinoma (8-10), in cell lines derived from cancerous prostatic tissues (11), and in Dunning R3327 rat prostatic adenocarcinomas (12,13). Recently, utilizing the mouse prostate reconstitution model system, it was demonstrated that activated ras or myc oncogenes singly were able to induce distinct dysplastic and hyperplastic lesions, respectively (14). The two oncogenes in combination induced rapidly growing, poorly differentiated malignant adenocarcinomas. Thus, the activation of the ras and myc oncogenes can induce a step-like progression of carcinogenesis in this experimental animal model.

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Authors and Affiliations

  1. Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA

    T. C. Thompson, D. Kadmon, W. F. Flanagan, S. Egawa, P. T. Scardino, S. Park & V. W. Merz

  2. Department of Pathology, Baylor College of Medicine, Houston, Texas, USA

    M. F. Arnall

  3. Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA

    T. C. Thompson

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Editor information

Editors and Affiliations

  1. Office of Scientific Administration, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA

    James P. Karr Ph.D. (Chief) (Chief)

  2. The Johns Hopkins Hospital and University, Marburg Building, 600 North Wolfe Street, Baltimore, MD, 21205, USA

    Donald S. Coffey Ph.D. (Professor of Urology, Oncology and Pharmacology) (Professor of Urology, Oncology and Pharmacology)

  3. Department of Growth Biochemistry and Physiology, Merck, Sharpe and Dohme Research Lab, 126 East Lincoln Avenue, Rahway, NJ, 07065, USA

    Roy G. Smith Ph.D.

  4. Mayo Clinic, Guggenheim-4 200 First Street, SW, Rochester, MN, 55905, USA

    Donald J. Tindall Ph.D. (Professor of Urologic Research) (Professor of Urologic Research)

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© 1991 Springer Science+Business Media New York

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Thompson, T.C. et al. (1991). Evidence for the Involvement of Genetic Differences and Mesenchymal Factors in the Progression of Oncogene-Induced Prostate Cancer in Reconstituted Mouse Prostate. In: Karr, J.P., Coffey, D.S., Smith, R.G., Tindall, D.J. (eds) Molecular and Cellular Biology of Prostate Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3704-5_37

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  • DOI: https://doi.org/10.1007/978-1-4615-3704-5_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6647-8

  • Online ISBN: 978-1-4615-3704-5

  • eBook Packages: Springer Book Archive

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