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Collagen Triple Helix Repeat Containing-1 (CTHRC1) Expression in Invasive Ductal Carcinoma of the Breast: The Impact on Prognosis and Correlation to Clinicopathologic Features

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Pathology & Oncology Research

Abstract

CTHRC1 has been known as a regulator of collagen expression and cell migration. The aim of this research was to clarify the clinicopathologic significance of CTHRC1 expression in human breast cancer. 22 cases of breast cancer tissues, randomly selected from clinically diagnosed patients, showed a significant increase of CTHRC1 mRNA expression compared to the normal tissue from the same patients using RT-PCR and real-time PCR. Additionally we investigated breast cancers from 189 patients by immunohistochemistry (IHC). A high level of CTHRC1 expression was observed in 111 (58.7 %) out of 189 breast cancer patients and the expression was significantly correlated with histologic grade (P = 0.026), nodal status (P < 0.001), and TNM pathologic stage (P = 0.002). High CTHRC1 expression was associated with a shorter recurrence free survival (P = 0.008). Taken together, the results showed that CTHRC1 over-expression was significantly associated with clinicopathological factors of poor prognosis in invasive ductal carcinoma. CTHRC1 could be used as a supplementary prognostic biomarker and a potential therapeutic target in breast cancer.

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Acknowledgements

This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A090509) and the basic science research program (20110028680) of the National Research Foundation funded by the Korean government (MEST).

Conflict of interest

The authors declare that they have no competing financial interests.

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Authors and Affiliations

  1. Department of Pathology, Eulji University School of Medicine, Daejeon, 301-070, Republic of Korea

    Joo Heon Kim, Tae-Hwa Baek & Hyun Sun Yim

  2. Preventive Medicine, Eulji University School of Medicine, Daejeon, 301-070, Republic of Korea

    Kyo Hyun Kim

  3. Department of Surgery, Medical School, Chonbuk National University, Chonju, 560-182, Republic of Korea

    Seong-Hoo Jeong

  4. Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 305-333, Republic of Korea

    Ho Bum Kang, Hee Gu Lee & Jae Wha Kim

  5. Division of Applied Life Science (BK21), PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju, 660-701, Republic of Korea

    Sang-seok Oh & Kwang Dong Kim

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  1. Joo Heon Kim
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  2. Tae-Hwa Baek
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Correspondence to Kwang Dong Kim.

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Kim, J.H., Baek, TH., Yim, H.S. et al. Collagen Triple Helix Repeat Containing-1 (CTHRC1) Expression in Invasive Ductal Carcinoma of the Breast: The Impact on Prognosis and Correlation to Clinicopathologic Features. Pathol. Oncol. Res. 19, 731–737 (2013). https://doi.org/10.1007/s12253-013-9636-y

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  • DOI: https://doi.org/10.1007/s12253-013-9636-y

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