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Neurotrophins

  • Chapter
Molecular and Cellular Biology of Neuroprotection in the CNS

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 513))

Abstract

Nerve growth factor was the first identified protein with anti-apoptotic activity on neurons. This prototypic neurotrophic factor, together with the three structurally and functionally related growth factors brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3) and neurotrophin-4/5 (NT4/5), forms the neurotrophin protein family. TargeT cells for neurotrophins include many neurons affected by neurodegenerative diseases such as Alzheimer s disease, Parkinson s disease, amyotrophic lateral sclerosis and peripheral polyneuropathies. In addition, the neurotrophins act on neurons affected by other neurological and psychiatric pathologies including ischemia, epilepsy, depression and eating disorders. Work with cell cultures and animal models provided solid support for the hypothesis that neurotrophins prevent neuronal death. While no evidence exists that a lack of neurotrophins underlies the etiology of any neurodegenerative disease, these studies have spurred on hopes that neurotrophins might be useful symptomatic-therapeutic agents. However first clinical trials led to variable results and severe side effects were observed. For future therapeutic use of the neurotrophins it is therefore crucial to expand our knowledge about their physiological functions as well as their pharmacokinetic properties. A major challenge is to develop methods for their application in effective doses and in a precisely timed and localized fashion.

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Authors and Affiliations

  1. Neurobiochemistry, Max-Planck-Institute of Neurobiology, Am Klopferspitz 18a, 82152, Martinsried, Germany

    Georg Dechant

  2. Neuroimmunology, Max-Planck-Institute of Neurobiology, Am Klopferspitz 18a, 82152, Martinsried, Germany

    Harald Neumann

  3. Neuroimmunology, European Neuroscience Institute G ttingen, Waldweg 33, 37073, G ttingen, Germany

    Harald Neumann

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  1. Institute of Physiology, University of Kiel, Kiel, Germany

    Christian Alzheimer

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Dechant, G., Neumann, H. (2003). Neurotrophins. In: Alzheimer, C. (eds) Molecular and Cellular Biology of Neuroprotection in the CNS. Advances in Experimental Medicine and Biology, vol 513. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0123-7_11

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