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Targeted Delivery of Nucleic Acid-Based Therapeutics to the Pulmonary Circulation

  • Emerging Drug Delivery Technologies
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Abstract

Targeted delivery of functional nucleic acids (genes and oligonucleotides) to pulmonary endothelium may become a novel therapy for the treatment of various types of lung diseases. It may also provide a new research tool to study the functions and regulation of novel genes in pulmonary endothelium. Its success is largely dependent on the development of a vehicle that is capable of efficient pulmonary delivery with minimal toxicity. This review summarizes the recent progress that has been made in our laboratory along these research directions. Factors that affect pulmonary nucleic acids delivery are also discussed.

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Acknowledgement

This work was supported by National Institutes of Health Grants HL-63080 and HL-68688 and by American Heart Association Grant 026540U.

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  1. Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 15261, USA

    Ramalinga Kuruba, Annette Wilson, Xiang Gao & Song Li

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  1. Ramalinga Kuruba
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  2. Annette Wilson
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  3. Xiang Gao
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Correspondence to Song Li.

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Kuruba, R., Wilson, A., Gao, X. et al. Targeted Delivery of Nucleic Acid-Based Therapeutics to the Pulmonary Circulation. AAPS J 11, 23–30 (2009). https://doi.org/10.1208/s12248-008-9073-0

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