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The Association of SNAP25 Gene Polymorphisms in Attention Deficit/Hyperactivity Disorder: a Systematic Review and Meta-Analysis

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Abstract

Attention deficit/hyperactivity disorder (ADHD) is one of the most highly heritable psychiatric disorders in childhood. The risk gene mutation accounts for about 60 to 90 % cases. Synaptosomal-associated protein of 25 kDa (SNAP-25) is a presynaptic plasma membrane protein which is expressed highly and specifically in the neuronal cells. A number of evidences have suggested the role of SNAP-25 in the etiology of ADHD. Notably, the animal model of coloboma mouse mutant bears a ∼2-cM deletion encompassing genes including SNAP25 and displays spontaneous hyperkinetic behavior. Previous investigators have reported association between SNPs in SNAP25 and ADHD, and controversial results were observed. In this study, we analyzed the possible association between six polymorphisms (rs3746544, rs363006, rs1051312, rs8636, rs362549, and rs362998) of SNAP25 and ADHD in a pooled sample of ten family-based studies and four case–control studies by using meta-analysis. The combined analysis results were significant only for rs3746544 (P = 0.010) with mild association (odds ratio (OR) = 1.14). And, the meta-analysis data for rs8636, rs362549, and rs362998 are the first time to be reported; however, no positive association was detected. In conclusion, we report some evidence supporting the association of SNAP25 to ADHD. Future research should emphasize genome-wide association studies in more specific subgroups and larger independent samples.

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Acknowledgments

This study is supported partially by the National Natural Science Foundation of China (81361120245, 31571039, 81101016, 81400816), Top-Notch Young Talents Program of China of 2014 to Dr. Ling-Qiang Zhu, Program of Outstanding Youth of Hubei Province, China (2014CFA017), and Program for Changjiang Scholars and Innovative Research Team in University (No. IRT13016).

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    Authors and Affiliations

    1. Key Laboratory of Environment and Health, Ministry of Education & Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China

      Yun-Sheng Liu, Xuan Dai, Fang-fen Yuan, Xue Gu & Jing Wu

    2. Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China

      Wei Wu

    3. Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China

      Jian-Guo Chen & Ling-Qiang Zhu

    4. Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China

      Jian-Guo Chen

    5. Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China

      Ling-Qiang Zhu

    Authors
    1. Yun-Sheng Liu
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    2. Xuan Dai
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    3. Wei Wu
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    4. Fang-fen Yuan
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    5. Xue Gu
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    6. Jian-Guo Chen
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    7. Ling-Qiang Zhu
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    8. Jing Wu
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    Corresponding authors

    Correspondence to Ling-Qiang Zhu or Jing Wu.

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    The authors declare that they have no conflicts of interest.

    Additional information

    Yun-Sheng Liu, Xuan Dai and Wei Wu contributed equally to this work.

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    Cite this article

    Liu, YS., Dai, X., Wu, W. et al. The Association of SNAP25 Gene Polymorphisms in Attention Deficit/Hyperactivity Disorder: a Systematic Review and Meta-Analysis. Mol Neurobiol 54, 2189–2200 (2017). https://doi.org/10.1007/s12035-016-9810-9

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    • DOI: https://doi.org/10.1007/s12035-016-9810-9

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