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Bridging the myoplasmic gap: recent developments in skeletal muscle excitation–contraction coupling

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Abstract

Conformational coupling between the L-type voltage-gated Ca2+ channel (or 1,4–dihydropyridine receptor; DHPR) and the ryanodine-sensitive Ca2+ release channel of the sarcoplasmic reticulum (RyR1) is the mechanistic basis for excitation–contraction (EC) coupling in skeletal muscle. In this article, recent findings regarding the roles of the individual cytoplasmic domains (the amino- and carboxyl-termini, cytoplasmic loops I–II, II–III, and III–IV) of the DHPR α1S subunit in bi-directional communication with RyR1 will be discussed.

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Acknowledgements

I thank Dr. K. G. Beam for his guidance. I would also like to thank Drs. B. A. Adams, S. Papadopoulos and D. C. Sheridan for their helpful comments. This work was supported by Muscular Dystrophy Association Development Grant MDA4155 to R. A. B.

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  1. Department of Physiology and Biophysics, School of Medicine, University of Colorado at Denver and Health Sciences Center, RC-1, North Tower, P18-7130, Mail Stop F8307, 12800 E. 19th St, Aurora, CO, 80045, USA

    Roger A. Bannister

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Bannister, R.A. Bridging the myoplasmic gap: recent developments in skeletal muscle excitation–contraction coupling. J Muscle Res Cell Motil 28, 275–283 (2007). https://doi.org/10.1007/s10974-007-9118-5

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