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Rearrangement and Activation of C-MYC Oncogene by Chromosome Translocation in B Cell Neoplasias

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Genetic Engineering

Part of the book series: Genetic Engineering ((GEPM,volume 6))

Abstract

Specific chromosomal abnormalities have long been associated with various human and murine neoplasias (1–3). The most common chromosome defects consist of band deletions, reciprocal translocations and in some cases trisomy of a specific chromosome (1–3). Until recently, the molecular basis of these chromosomal rearrangements and the significance of their association with specific malignancies remained unknown. Cellular oncogenes (almost invariably found to be homologues of retroviral transforming genes) have been shown to exist in an activated form in a variety of human cancers. In the past year, a number of oncogenes have been localized to specific chromosome bands displaying abnormalities unique to specific neoplasias (2,3).

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References

  1. Klein, G. (1981) Nature 294, 313–318.

    Article  PubMed  CAS  Google Scholar 

  2. Rowley, J.P. (1982) Science 216, 749–751.

    Article  PubMed  CAS  Google Scholar 

  3. Yunis, J.L. (1983) Science 221, 227–236.

    Article  PubMed  CAS  Google Scholar 

  4. Taub, R., Kirsch, I., Morton, C., Lenoir, G., Swan, D., Tronick S., Aaronson, S. and Leder, P. (1982) Proc. Nat. Acad. Sci. U.S.A. 79, 7837–7841.

    Article  PubMed  CAS  Google Scholar 

  5. Dalla-Favera, R., Bregni, M., Erikson, J., Patterson, D., Gallo, R.C. and Crose, C.M. (1982) Proc. Nat. Acad. Sci. U.S.A. 79, 7824–7827.

    Article  PubMed  CAS  Google Scholar 

  6. Neel, B.G., Jhanivar, S.C., Chaganti, R.S.K. and Hayward, W.S. (1982) Proc. Nat. Acad. Sci. U.S.A. 79, 7843–7846.

    Google Scholar 

  7. Harris, L.J., D’Eustachio, P., Ruddle, F.H. and Marcu, K.B. (1982) Proc. Nat. Acad. Sci. U.S.A. 79, 6622–6626.

    Article  PubMed  CAS  Google Scholar 

  8. Calame, K., Kim, S., Lalley, P., Hill, R., Davis, M. and Hood, L. (1982) Proc. Nat. Acad. Sci. U.S.A. 79, 6994–6998.

    Article  PubMed  CAS  Google Scholar 

  9. Cory, S., Adams, J.M., Gerondakis, S.D., Miller, J.F.A.P., Gamble, J., Weiner, F., Spira, J. and Francke, U. (1983) EMBO J. 2, 213–216.

    PubMed  CAS  Google Scholar 

  10. Ohno, S., Babonits, M., Wiener, F., Spira, J., Klein, G. and Potter, M. (1979) Cell 18, 1001–1007.

    Article  PubMed  CAS  Google Scholar 

  11. Weiner, F., Babonits, M., Spira, J., Klein, G. and Potter, M. (1980) Somatic Cell Genet. 6, 731–738.

    Article  Google Scholar 

  12. Kirsch, I.R., Morton, C.C., Nakahara, K. and Leder, P. (1982) Science 216, 301–303.

    Article  PubMed  CAS  Google Scholar 

  13. Meo, T., Johnson, J., Beechey, C.V., Andrews, S.J., Peters, J. and Searle, A.G. (1980) Proc. Nat. Acad. Sci. U.S.A. 77, 550–553.

    Article  PubMed  CAS  Google Scholar 

  14. D’Eustachio, P., Pravtcheva, D., Marcu, K.B. and Ruddle, F.H. (1980) J. Exp. Med. 151, 1545–1550.

    Google Scholar 

  15. Bernheim, A., Berger, R. and Lenoir, G. (1981) Cancer Genet. Cytogenet. 3, 307–315.

    Article  PubMed  CAS  Google Scholar 

  16. Malcolm, S., Barton, P., Murphy, C., Fergusson-Smith, M.A., Bentley, D.L. and Rabbits, T.H. (1982) Proc. Nat. Acad. Sci. U.S.A. 79, 4957–4961.

    Article  PubMed  CAS  Google Scholar 

  17. McBride, O.W., Heiter, P.A., Hollis, G.F., Swan, D., Otey, M.C., and Leder, P. (1982) J. Exp. Med. 155, 1680–1690.

    Google Scholar 

  18. Malcolm, S., Barton, P., Bentley, D.L., Fergusson-Smith, M.A., Murphy, C. and Rabbitts, T.H. (1982) Cytogenet. Cell Genet. 32, 296.

    Google Scholar 

  19. Early, P., Huang, H., Davis, M., Calame, K. and Hood, L. (1980) Cell 19, 981–992.

    Article  PubMed  CAS  Google Scholar 

  20. Sakano, H., Maki, R., Kurosawa, Y., Roeder, W. and Tonegawa, S. (1980) Nature 286, 676–683.

    Article  PubMed  CAS  Google Scholar 

  21. Davis, M.M., Calame, K., Early, P.W., Livant, D.L., Joho, R., Weissman, I.L. and Hood, L. (1980) Nature 283, 733–739.

    Article  PubMed  CAS  Google Scholar 

  22. Kataoka, T., Kawakami, T., Takahashi, N. and Honjo, T. (1980) Proc. Nat. Acad. Sci. U.S.A. 77, 919–923.

    Article  PubMed  CAS  Google Scholar 

  23. Nikaido, T., Nakai, S. and Honjo, T. (1981) Nature 292, 845–848.

    Article  PubMed  CAS  Google Scholar 

  24. Shimizu, A., Takahashi, N., Yaoita, Y. and Honjo, T. (1982) Cell 28, 499–506.

    Article  PubMed  CAS  Google Scholar 

  25. Stanton, L.W. and Marcu, K.B. (1982) Nucl. Acids Res. 10, 5993–6006.

    Article  PubMed  CAS  Google Scholar 

  26. Marcu, K.B. (1982) Cell 29, 719–721.

    Article  PubMed  CAS  Google Scholar 

  27. Nikaido, T., Yamawaki-Kataoka, Y. and Honjo, T. (1982) J. Biol. Chem. 257, 7322–7329.

    PubMed  CAS  Google Scholar 

  28. Marcu, K.B., Lang, R.B., Stanton, L.W. and Harris, L.J. (1982) Nature 299, 87–89.

    Article  Google Scholar 

  29. Kirsch, I.R., Ravetch, J.V., Kwan, S.P., Max, E.E., Ney, R.L. and Leder, P. (1981) Nature 293, 585–587.

    Article  PubMed  CAS  Google Scholar 

  30. Lang, R.B., Stanton, L.W. and Marcu, K.B. (1982) Nucl. Acids Res. 10, 611–630.

    Article  PubMed  CAS  Google Scholar 

  31. Harris, L.J., Lang, R.B. and Marcu, K.B. (1982) Proc. Nat. Acad. Sci. U.S.A. 79, 4175–4179.

    Article  PubMed  CAS  Google Scholar 

  32. Adams, J.M., Gerondakis, S., Webb, E., Mitchell, J., Bernard, O. and Cory, S. (1982) Proc. Nat. Acad. Sci. U.S.A. 79, 6966–6970.

    Article  PubMed  CAS  Google Scholar 

  33. Greenberg, R., Lang, R.B., Diamond, M.S. and Marcu, K.B. (1982) Nucl. Acids Research 10, 7751–7761.

    Article  CAS  Google Scholar 

  34. Shen-Ong, G.L.C., Keath, E., Picolli, S.P. and Cole, M.D. (1982) Cell 31, 443–452.

    Article  PubMed  CAS  Google Scholar 

  35. Mushinski, J.F., Bauer, S.R., Potter, M. and Reddy, E.P. (1983) Proc. Nat. Acad. Sci. U.S.A. 80, 1073–1077.

    Article  PubMed  CAS  Google Scholar 

  36. Riblet, R.J. (1977) in the Immune System: Genetics and Regulation (E.E. Secarz, L.A. Herzenberg and C.F. Fox, eds.) pp. 83–89, Academic Press, New York, NY.

    Google Scholar 

  37. Owen, F.L., Riblet, R. and Taylor, B.A. (1981) J. Exp. Med. 153, 801–810.

    Article  PubMed  CAS  Google Scholar 

  38. Crews, S., Barth, R., Hood, L., Prehn, J. and Calame, K. (1982) Science 218, 1319–1321.

    Article  PubMed  CAS  Google Scholar 

  39. Marcu, K.B., Harris, L.J., Stanton, L.W., Erickson, J., Watt, R. and Croce, C.M. (1983) Proc. Nat. Acad. Sci. U.S.A. 80, 519–523.

    Article  PubMed  CAS  Google Scholar 

  40. Adams, J., Gerondakis, S., Webb, E., Corcoran, L.M. and Cory, S. (1983) Proc. Nat. Acad. Sci. U.S.A. 80, 1982–1986.

    Article  PubMed  CAS  Google Scholar 

  41. Mushinski, J.F. (1983) in Mechanisms of B Cell Neoplasia, pp. 199–209, Editones Roche, Basel, Switzerland.

    Google Scholar 

  42. Stanton, L.W., Watt, R. and Marcu, K.B. (1983) Nature 303, 401–406.

    Article  PubMed  CAS  Google Scholar 

  43. Cory, S., Gerondakis, S. and Adams, J.M. (1983) EMBO J. 2, 697–703.

    PubMed  CAS  Google Scholar 

  44. Cory, S., Gerondakis, S. and Adams, J.M. (1983) EMBO J. 2, 697–703.

    PubMed  CAS  Google Scholar 

  45. Watt, R., Stanton, L.W., Marcu, K.B., Gallo, R.C., Croce, C.M. and Rovera, G. (1983) Nature 303, 725–728.

    Article  PubMed  CAS  Google Scholar 

  46. Watt, R., Nishikura, K., Sorrentino, J., ar-Rushdi, A., Croce, C.M. and Rovers, G. (1983) Proc. Nat. Acad. Sci. U.S.A. (in press).

    Google Scholar 

  47. Hamlyn, P.H. and Rabbitts, T.H. (1983) Nature 304, 135–139.

    Article  PubMed  CAS  Google Scholar 

  48. Donner, P., Greisser-Wilke, I and Moelling, K. (1982) Nature 296, 262–266.

    Article  PubMed  CAS  Google Scholar 

  49. Abrams, H.D., Rohrschneider, L.R. and Eisenman, R.N. (1982) Cell 29, 427–439.

    Article  PubMed  CAS  Google Scholar 

  50. Colby, W.W., Chen, E.Y., Smith, D.H. and Levinson, A.D. (1983) Nature 301, 722–725.

    Article  PubMed  CAS  Google Scholar 

  51. Cole, M.D. (1983) in Mechanisms of B Cell Neoplasia, pp. 353–360, Editones Roche, Basel, Switzerland.

    Google Scholar 

  52. Cole, M.D. (1983) in Mechanisms of B Cell Neoplasia, pp. 353–360, Editones Roche, Basel, Switzerland.

    Google Scholar 

  53. Dalla-Favera, R., Martinotti, S., Gallo, R.C., Erikson, J. and Croce, C.M. (1983) Science 219, 963–967.

    Article  PubMed  CAS  Google Scholar 

  54. Erikson, J., ar-Rushdi, A., Drwinga, H.L., Nowell, P.C. and Croce, C.M. (1983) Proc. Nat. Acad. Sci. U.S.A. 80, 820–824.

    Article  Google Scholar 

  55. Nishikura, K., ar-Rushdi, A., Erikson, J., Watt, R., Rovera, G. and Croce, C.M. (1983) Proc. Nat. Acad. Sci. U.S.A. 80, 4822–4826.

    Article  PubMed  CAS  Google Scholar 

  56. Banerji, J., Olson, L. and Schaffner, W. (1983) Cell 33, 729–740.

    Article  PubMed  CAS  Google Scholar 

  57. Gillies, S.D., Morrison, S.L., Oi, V.T. and Tonegawa, S. (1983) Cell 33, 717–728.

    Article  PubMed  CAS  Google Scholar 

  58. Perry, R.P. (1983) Cell 33, 647–649.

    Article  PubMed  CAS  Google Scholar 

  59. Mushinski, J.F. (1983) in Mechanisms of B Cell Neoplasia, pp. 368–371, Editones Roche, Basel, Switzerland.

    Google Scholar 

  60. Payre, G.S., Courtneidge, S.A., Crittenden, L.B., Fadly, A.M., Bishop, J.M. and Varmus, H.E. (1981) Cell 23, 311–322.

    Article  Google Scholar 

  61. Neel, B.G, Hayward, W.S., Robinson, H.L., Fang, J. and Astrin, S.M. (1981) Cell 23, 323–334.

    Article  PubMed  CAS  Google Scholar 

  62. Hayward, W.S., Neel, B.G. and Astrin, S.M. (1982) Nature 290, 475–480.

    Article  Google Scholar 

  63. Klein, G. (1983) Cell 32, 311–315.

    Article  PubMed  CAS  Google Scholar 

  64. Collins, S. and Groudine, M. (1982) Nature 298, 679–681.

    Article  PubMed  CAS  Google Scholar 

  65. Dalla-favera, R., Wong-Staal, F. and Gallo, R.C. (1982) Nature 299, 61–63.

    Article  PubMed  CAS  Google Scholar 

  66. Lane, M.-A., Sainten, A. and Cooper, G.M. (1982) Cell 28, 873–880.

    Article  PubMed  CAS  Google Scholar 

  67. Groubin, G., Goldman, D.S., Luce, J., Neiman, P.E. and Cooper, G.M. (1983) Nature 302, 114–119.

    Article  Google Scholar 

  68. Murray, M.J., Cunningham, J.M., Parada, L.F., Dautry, F., Lebowitz, P. and Weinberg, R.A. (1983) Cell 33, 749–757.

    Article  PubMed  CAS  Google Scholar 

  69. Land, H., Parada, L.F. and Weinberg, R.A. (1983) Nature 304, 596–602.

    Article  PubMed  CAS  Google Scholar 

  70. Ruley, H.E. (1983) Nature 304, 602–606.

    Article  PubMed  CAS  Google Scholar 

  71. Sharon, J., Kabat, E. and Morrison, S. (1981) Mol. Immunol. 18, 821–846.

    Article  Google Scholar 

  72. Matsuuchi, L., Sharon, J. and Morrison, S. (1981) J. Immunol. 127, 2188–2190.

    PubMed  CAS  Google Scholar 

  73. Sanger, F., Nicklen, S. and Coulson, A.R. (1977) Proc. Nat. Acad. Sci. U.S.A. 74, 5463–5467.

    Article  PubMed  CAS  Google Scholar 

  74. Messing, J., Crea, R. and Seeburg, P.H. (1981) Nucl. Acids Res. 9, 309–322.

    Article  PubMed  CAS  Google Scholar 

  75. Davis, M.M., Kim, S.K. and Hood, L. (1980) Science 209, 1360–1365.

    Article  PubMed  CAS  Google Scholar 

  76. Corden, J., Wasyly K.B., Buchwalder, A., Saasone-Corsi, P., Kedinger, C. and Chambon, P. (1980) Science 209, 1406–1414.

    Article  PubMed  CAS  Google Scholar 

  77. Benoist, C., O’Hare, K., Breathnach, R. and Chambon, P. (1980) Nucl. Acids Res. 8, 127–142.

    Article  PubMed  CAS  Google Scholar 

  78. Alitalo, K., Bishop, J.M., Smith, D.H., Chen, E.Y., Colby, W.W. and Levinson, A.O. (1983) Proc. Nat. Acad. Sci. U.S.A. 80, 100–104.

    Article  PubMed  CAS  Google Scholar 

  79. Southern, E.M. (1975) J. Mol. Biol. 98, 503–517.

    Article  PubMed  CAS  Google Scholar 

  80. Wahl, G.M., Stern, M. and Stark, G.R. (1979) Proc. Nat. Acad. Sci. U.S.A. 76, 3683–3687.

    Article  PubMed  CAS  Google Scholar 

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Author information

Author notes

  1. Linda J. Harris

    Present address: Genetic Systems Corporation, 3005 First Ave., Seattle, WA, 98121, USA

  2. Rosemary Watt

    Present address: Smith Kline and French Laboratories, Philadelphia, PA, 19101, USA

  3. Robert Greenberg

    Present address: Department of Molecular Biology, Shearing Corporation, 86 Orange St., Bloomfield, NY, 07003, USA

Authors and Affiliations

  1. Biochemistry Department, State University of New York at Stony Brook, Stony Brook, NY, 11794, USA

    Kenneth B. Marcu, Lawrence W. Stanton, Linda J. Harris, Jian-ging Yang, Elaine Remmers, Robert Greenberg & Paul Fahrlander

  2. Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, Philadelphia, PA, 19104, USA

    Rosemary Watt

  3. Cell Biology Department, Albert Einstein College of Medicine, Bronx, NY, 10462, USA

    Laurel Eckhardt & Barbara Birshtein

Authors
  1. Kenneth B. Marcu
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  2. Lawrence W. Stanton
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Editor information

Editors and Affiliations

  1. Brookhaven National Laboratory, Upton, New York, USA

    Jane K. Setlow

  2. Associated Universities, Inc., Washington, D.C., USA

    Alexander Hollaender

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Marcu, K.B. et al. (1984). Rearrangement and Activation of C-MYC Oncogene by Chromosome Translocation in B Cell Neoplasias. In: Setlow, J.K., Hollaender, A. (eds) Genetic Engineering. Genetic Engineering, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4793-4_6

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