Abstract
Nuclear factor-κB (NF-κB) transcription factors and the IκB kinases (IKKs) that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-κB signaling also has a critical role in cancer development and progression. The canonical NF-κB pathway contributes to squamous cell carcinoma (SCC) development by interacting with other signaling pathways including tumor suppressive and oncogenic pathways in a tissue specific manner. In this chapter, we will summarize recent advances in the understanding of interconnections between NF-κB and IKKs, including IKKα which has NF-κB independent functions, in the context of SCC development and progression and as potential target for novel chemotherapy approaches.
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Costanzo, A., Spallone, G., Karin, M. (2011). NF-κB, IκB Kinase and Interacting Signal Networks in Squamous Cell Carcinomas. In: Glick, A., Waes, C. (eds) Signaling Pathways in Squamous Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7203-3_10
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