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Study of Glutathione Peroxidase (GPX) Activity Among Betel Quid Chewers of Indian Population

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Study of Glutathione Peroxidase (GPX) Activity Among Betel Quid Chewers of Indian Population


Aniket Adhikari | Madhusnata De

https://doi.org/10.31142/ijtsrd21619



Aniket Adhikari | Madhusnata De "Study of Glutathione Peroxidase (GPX) Activity Among Betel Quid Chewers of Indian Population" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-3, April 2019, pp.70-73, URL: https://www.ijtsrd.com/papers/ijtsrd21619.pdf

Introduction: Betel quid (BQ) chewing, a habit practiced in Eastern and North Eastern part of India, has known to be associated with cancer of the oral or buccal cavity. BQ is also one of the common mood elevating substances among Indian population. The BQ is a mixture of areca nut(Areca catechu), catechu (Acacia catechu) and slaked lime(calcium oxide and calcium hydroxide) wrapped in a betel leaf (Piper betel) .BQ products have been classified by the International Agency for Research on Cancer (IARC) as group I human carcinogens . Glutathione peroxidise (GPx), one of the major enzymatic antioxidant defence system, responsible for scavenging free radicals. Antioxidant enzymes catalyze decomposition of ROS. Overall balance between production and removal of ROS may be more important in various cancers including OSCC (Oral squamous cell carcinoma) or oral cancer. Methods: In this study subjects were screened from Department of Oral and Maxillofacial surgery &E.N.T. of Ramakrishna Mission Seva Pratishthan Hospital (RKMSP), Kolkata and different areas of West Bengal and North Eastern states of India. Quantitative in vitro determination of glutathione peroxidase activities in whole blood were estimated manually with 0.05 ml whole blood. The samples were assayed by UV-Visible Spectrophotometer (SPECORD 50 PLUS) at a wavelength of 340nm. Results: Most of the subjects had betel quid chewing habit. Glutathione peroxidase values are higher in healthy control than Cancer cases and Pre cancer with betel quid chewing habit, which is statistically significant. Conclusion: Reactive oxygen species are generated due to slaked lime, one of the important constituents of betel quid which can modulate the oral pathology and promote carcinogenesis.

Glutathione peroxidase, Betel quid, Oral cancer


IJTSRD21619
Volume-3 | Issue-3, April 2019
70-73
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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