PREPARATION AND CHARACTERIZATION OF SPHERICAL AGGLOMERATED CRYSTALS LOADED FAST DISSOLVING TABLETS FOR ENHANCING THE SOLUBILITY OF IBUPROFEN

The objective of the present work was to study the effect of different polymers on the solubility and dissolution rate of ibuprofen a poorly water soluble NSAIDs, by spherically agglomeration using methanol, water and dichloromethane as good solvent, poor solvent and bridging liquid, respectively. The quasi-emulsion solvent diffusion technique was used as a method for spherical agglomeration. Spherical agglomeration of ibuprofen were prepared by using polyethylene glycol-4000, polyethylene glycol-6000 and PVP k-30 as water soluble carries proportions like 1:0.5,1:0.75,1:1. The agglomerates were subjected to various physicochemical evaluations such as practical yield, drug content, solubility, flow properities, average particle size,scanning electron microscopy and dissolution studies. The optical electron microscopy studies showed that the agglomerates posseeses a good spherical shape. This study, demonstrated that the successful development of directly compressible spherical agglomerates of ibuprofen prepared with hydrophilic polymers enhances the in-vitro dissolution property of ibuprofen, whichcould provide rapid onset of action and potentially increases oral bioavailabilityThe dissolution rate of Ibuprofen was found to be effected by nature of the superdisintegrant used in the preparation of tablets. Based on the dissolution rate, superdisintegrants can be rated as SSG < Croscarmalose sodium < Crospovidone. The formulation prepared with Crospovidone was offered relatively rapid release of Ibuprofen when compared with other superdisintegrants used in this investigation. Keywords: Ibuprofen, inflammation, Spherical Agglomerates, Emulsion solvent diffusion