IP Journal of Surgery and Allied Sciences

Online ISSN: 2582-6387

IP Journal of Surgery and Allied Sciences (JSAS) open access, peer-reviewed quarterly journal publishing since 2019 and is published under the Khyati Education and Research Foundation (KERF), is registered as a non-profit society (under the society registration act, 1860), Government of India with the vision of various accredited vocational courses in healthcare, education, paramedical, yoga, publication, teaching and research activity, with the aim of faster and better dissemination of knowledge, we will be publishing the article ‘Ahead more...

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Original Article


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43-50


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Gursagar Singh Sahota, Faraz Ahmed*, Vijay Kumar Singh, Anit Parihaar, Wahid Ali, Surender Kumar, Devendra Singh (Late)


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Serial estimation of serum myeloperoxidase in patients of acute pancreatitis: A pilot study


Original Article

Author Details : Gursagar Singh Sahota, Faraz Ahmed*, Vijay Kumar Singh, Anit Parihaar, Wahid Ali, Surender Kumar, Devendra Singh (Late)

Volume : 3, Issue : 2, Year : 2021

Article Page : 43-50

https://doi.org/10.18231/j.jsas.2021.012



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Abstract

Introduction: Acute pancreatitis (AP) is an inflammatory condition having varied presentation ranging from a mild self-limiting illness to a severe disease with multi organ failure. Excessive recruitment of leukocytosis is an important pathophysiological feature and Myelo-peroxidase (MPO) forms an important part of neutrophil induced inflammation. The current prognostic criteria are complex and cumbersome.
Methods: The present cross sectional pilot study serial estimation of plasma MPO levels were done at the time of admission and on 3, 7 and 14 days in patient of Acute Pancreatitis (n=64) patient with acute abdominal symptoms (n=15) otherthan acute pancreatitidand healthy volunteers (n=15). The values of serum MPO levels were correlated with Ransons`s score, Apache score, CT severity index and patient developing local and systemic complications due to acute pancreatitis. Serum MPO levels in (mU/ml) were measured by colorimetric Assay kit (bio Vision, USA). Statistical Analysis on SPSS (Windows version 21.0)
Results: The mean serum MPO levels were significantly high in patients of AP as compared to controls comprising of patients with acute abdominal conditions and healthy individuals (mean 12.73 vs 1.67 mU/ml. p< 0 n=21 n=43> Conclusion: The higher serum MPO levels correlated with more severe diseases, worse outcome and can be a simple and effective prognostic indicator in AP.

Keywords: Severe Pain, Biochemical marker, Pancreatitis


How to cite : Sahota G S, Ahmed F, Singh V K, Parihaar A, Ali W, Kumar S, (late) D S, Serial estimation of serum myeloperoxidase in patients of acute pancreatitis: A pilot study. IP J Surg Allied Sci 2021;3(2):43-50

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