The correlation of prognostic factors and clinical outcomes in patients with osteosarcoma – An observational study

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Original Article

Author Details : Subbiah Shanmugam*, Syed Afroze Hussain, Rajkiran Thanikachalam

Volume : 5, Issue : 2, Year : 2020

Article Page : 169-173

https://doi.org/10.18231/j.jdpo.2020.034

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Abstract

Context: Osteosarcoma is characterized by the production of malignant osteoid. It arises typically in the
adolescent age group.
Aims: The purpose of this study is to analyze the impact of various prognostic factors on survival in
osteosarcoma patient admitted in our institution.
Settings and Design: Retrospective observational study of 10 years duration from 2007 to 2017
Methods and Materials: There were 66 patients in the records. As a part of the staging work up, CT and
MRI of the local part and CECT CHEST were performed . All patients received adriamycin and cisplatin
with or without Ifosfamide, and PCVE regimen.
Statistical analysis used: IBM SPSS Statistics version 20. Survival and percentage of necrosis was
correlated by Spearman Rank correlation.
Results: Sixty six patients were included in this study. The median survival of patient who underwent limb
salvage surgery (LSS) was 28 months and that of patient underwent amputation was 17 months. No
statistically significant survival advantage present between the two group (p=0.68). There is a statistically
significant difference in percentage of necrosis in patient who receive neoadjuvant chemotherapy if
ifosfamide is added to the regime (p=0.006). Spearman Rank correlation revealed that there was a
strong positive Correlation (0.418) between the percentage of necrosis and survival. The correlation was
statistically significant (p = 0.02).
Conclusions: LSS in osteosarcoma is a safe alternative to amputation. Response to chemotherapy, with
regards to necrosis correlates well with survival, thus clearly emphasizing the role of chemotherapy in the
management of these tumors.

Keywords: OSTEOSARCOMA, Limb salvage surgery, Amputation.

How to cite : Shanmugam S, Hussain S A, Thanikachalam R, The correlation of prognostic factors and clinical outcomes in patients with osteosarcoma – An observational study. IP J Diagn Pathol Oncol 2020;5(2):169-173

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