Indian Journal of Pharmacy and Pharmacology

Print ISSN: 2393-9079

Online ISSN: 2393-9087

CODEN : IJPPTK

Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award programs. With more...

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174-179


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BALLO Mahamadou N. H*, Youl Estelle N.H , Traore Karim, Diakite A.S Seidina, Diakite Mamadou, Ouedraogo Moussa, Sanogo Rokia, Bah Sekou


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study of antiradical activity, phospholipase A and 15-lipoxygenase inhibitory activity of eight malian medicinal plants used by traditional healers to treat inflammatory diseases


Original Article

Author Details : BALLO Mahamadou N. H*, Youl Estelle N.H , Traore Karim, Diakite A.S Seidina, Diakite Mamadou, Ouedraogo Moussa, Sanogo Rokia, Bah Sekou

Volume : 9, Issue : 3, Year : 2022

Article Page : 174-179

https://doi.org/10.18231/j.ijpp.2022.031



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Abstract

Pro-inflammatory enzymes play a key role in inflammatory processes and are potential targets of anti-inflammatory drugs. In this study, the objective was to evaluate the antiradical activity of the extracts and their ability to inhibit phospholipase A and 15-lipoxygenase activity. The hydroethanolic extract of revealed the strongest reducing power with an IC of 7.29 ± 0.61 µg/mL. The three most active extracts on PLA were hydroethanolic extracts of (IC of 21.43 ± 0.66 ?g/mL), (IC of 23.72 ± 0.71 µg/mL), (IC of 24.49 ± 0.39 µg/mL). The best inhibitory activity on 15-lipoxigenase was obtained with aqueous and hydroethanolic extracts of with IC of 18.35 ± 1.26; 18.47 ± 1.12 µg/mL respectively. The present study showed that extracts of leaves of and roots of have antioxidant activity and effectively inhibit sPLA, and 15-LOX pro-inflammatory enzymes


Keywords: Phospholipase A2, Ximenia americana, Terminalia macroptera, Cochlospermum tinctorium, Ximenia americana, 15-lipoxygenase, ABTS, Mali.


How to cite : Ballo Mahamadou N. H, N.h Y E, Karim T, Seidina D A , Mamadou D , Moussa O, Rokia S, Sekou B, study of antiradical activity, phospholipase A and 15-lipoxygenase inhibitory activity of eight malian medicinal plants used by traditional healers to treat inflammatory diseases. Indian J Pharm Pharmacol 2022;9(3):174-179

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