Indian Journal of Pharmacy and Pharmacology

Print ISSN: 2393-9079

Online ISSN: 2393-9087

CODEN : IJPPTK

Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award programs. With more...

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Review Article


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164-170


Authors Details

Abhijit Anil Trailokya*, Debanu Ghosh Roy, Prafulla Kerkar, Shahid Merchant, Rajeev Sethi, Rajiv Karnik, S. C. Manchanda, Sadanand Shetty, Uday Jadhav, Vinod Vijan


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Right selection of oral anticoagulation for stroke prevention in atrial fibrillation


Review Article

Author Details : Abhijit Anil Trailokya*, Debanu Ghosh Roy, Prafulla Kerkar, Shahid Merchant, Rajeev Sethi, Rajiv Karnik, S. C. Manchanda, Sadanand Shetty, Uday Jadhav, Vinod Vijan

Volume : 9, Issue : 3, Year : 2022

Article Page : 164-170

https://doi.org/10.18231/j.ijpp.2022.029



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Abstract

Atrial fibrillation (AF) is considered as one of the most common cardiac arrhythmias worldwide and is always associated with a significantly increased risk of stroke and thromboembolism. VKAs (Warfarin & Acenocoumarol) are highly effective in reducing the risk of stroke in patients with AF, but bleeding issues & disutility sparked the development of direct oral anticoagulants (DOACs) or NOACs (Novel oral anticoagulants). These drugs, offer the convenience of once or twice daily dosing without the need for laboratory monitoring of coagulation activity (PT/ INR) or routine dose adjustment. Various clinical trials proved their non-inferiority to warfarin (VKA) in reducing the risk of stroke or systemic embolism, and each was associated with markedly lower rates of ICH than well-adjusted warfarin. Yet there are no direct head-to-head comparative trials for the efficacy & safety of NOACs. In this review we try to provide patient centric approach to assist Indian physicians in selecting right OAC therapy for SPAF with respect to best possible evidence and recommendations available worldwide.


Keywords: Anticoagulation, NOACs, SPAF, Apixaban, Dabigatran, Rivaroxaban, Atrial fibrillation (AF)


How to cite : Trailokya A A, Roy D G, Kerkar P, Merchant S, Sethi R, Karnik R, Manchanda S C, Shetty S, Jadhav U, Vijan V, Right selection of oral anticoagulation for stroke prevention in atrial fibrillation. Indian J Pharm Pharmacol 2022;9(3):164-170

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